Specificity redirection by CAR with human VEGFR-1 affinity endows T lymphocytes with tumor-killing ability and anti-angiogenic potency

Autor: Ting Liu, Fuchun Guo, Mo Bh, Jiyao Li, Huashan Shi, Jie Zhang, Li Wang, Yu Ma, Yantong Liu, Dan Li, Fuqiang Wen, Wei Wang, Yu Quan Wei, Ye Wang

Publikováno v: Gene therapy. 20(10)

Immunotherapy that is based on adoptive transfer of T lymphocytes, which are genetically modified to express chimeric antigen receptors (CARs) that recognize tumor-associated antigens, has been demonstrated to be an efficient cancer therapy. Vascular

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3f6233e587fd11f83623d5529a2c4a8
https://pubmed.ncbi.nlm.nih.gov/23636245

Prenatal inflammation exposure-programmed hypertension exhibits multi-generational inheritance via disrupting DNA methylome.

Autor: Guan X; Institute of Materia Medica, College of Pharmacy, Army Medical University (Third Military Medical University), Chongqing, 400038, China., Dan GR; Institute of Materia Medica, College of Pharmacy, Army Medical University (Third Military Medical University), Chongqing, 400038, China., Yang Y; Institute of Materia Medica, College of Pharmacy, Army Medical University (Third Military Medical University), Chongqing, 400038, China., Ji Y; Institute of Materia Medica, College of Pharmacy, Army Medical University (Third Military Medical University), Chongqing, 400038, China., Lai WJ; Institute of Materia Medica, College of Pharmacy, Army Medical University (Third Military Medical University), Chongqing, 400038, China., Wang FJ; Institute of Materia Medica, College of Pharmacy, Army Medical University (Third Military Medical University), Chongqing, 400038, China., Meng M; Institute of Materia Medica, College of Pharmacy, Army Medical University (Third Military Medical University), Chongqing, 400038, China., Mo BH; Institute of Materia Medica, College of Pharmacy, Army Medical University (Third Military Medical University), Chongqing, 400038, China., Huang P; Institute of Materia Medica, College of Pharmacy, Army Medical University (Third Military Medical University), Chongqing, 400038, China., You TT; Institute of Materia Medica, College of Pharmacy, Army Medical University (Third Military Medical University), Chongqing, 400038, China., Deng YF; Institute of Materia Medica, College of Pharmacy, Army Medical University (Third Military Medical University), Chongqing, 400038, China., Song L; Institute of Materia Medica, College of Pharmacy, Army Medical University (Third Military Medical University), Chongqing, 400038, China., Guo W; Institute of Materia Medica, College of Pharmacy, Army Medical University (Third Military Medical University), Chongqing, 400038, China., Yi P; Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, 401120, China., Yu JH; The Ohio State University Comprehensive Cancer Center and the James Cancer Hospital, Columbus, OH, 43210, USA.; Department of Hematology & Hematopoietic Cell Transplantation, City of Hope National Medical Center and Beckman Research Institute, Duarte, CA, 91010, USA., Gao Y; Southwest Hospital/Southwest Eye Hospital, Army Medical University (Third Military Medical University), Chongqing, 400038, China., Shou WN; Institute of Materia Medica, College of Pharmacy, Army Medical University (Third Military Medical University), Chongqing, 400038, China.; Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, 46202, USA., Chen BB; Laboratory Animal Center, Army Medical University (Third Military Medical University), Chongqing, 400038, China. chenbb81@126.com., Deng YC; Institute of Materia Medica, College of Pharmacy, Army Medical University (Third Military Medical University), Chongqing, 400038, China. youcai.deng@tmmu.edu.cn., Li XH; Institute of Materia Medica, College of Pharmacy, Army Medical University (Third Military Medical University), Chongqing, 400038, China. lpsh008@aliyun.com.

Publikováno v: Acta pharmacologica Sinica [Acta Pharmacol Sin] 2022 Jun; Vol. 43 (6), pp. 1419-1429. Date of Electronic Publication: 2021 Sep 30.

MicroRNA-486-5p targeting PTEN Protects Against Coronary Microembolization-Induced Cardiomyocyte Apoptosis in Rats by activating the PI3K/AKT pathway.

Autor: Zhu HH; Department of Cardiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China., Wang XT; Department of Cardiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China., Sun YH; Department of Cardiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China., He WK; Department of Cardiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China., Liang JB; Department of Cardiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China., Mo BH; Department of Cardiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China., Li L; Department of Cardiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China. Electronic address: drlilang99@sina.com.

Publikováno v: European journal of pharmacology [Eur J Pharmacol] 2019 Jul 15; Vol. 855, pp. 244-251. Date of Electronic Publication: 2019 May 07.

Pim1 Overexpression Prevents Apoptosis in Cardiomyocytes After Exposure to Hypoxia and Oxidative Stress via Upregulating Cell Autophagy.

Autor: Zhu HH, Wang XT, Sun YH, He WK, Liang JB, Mo BH, Li L

Publikováno v: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology [Cell Physiol Biochem] 2018; Vol. 49 (6), pp. 2138-2150. Date of Electronic Publication: 2018 Sep 26.

Authentication of Chinese crude drug gecko by DNA barcoding.

Autor: Gu HF; Chengdu Institute ofBiology, Chinese Academy of Sciences, Chengdu, PR China., Xia Y, Penga R, Mo BH, Li L, Zenga XM

Publikováno v: Natural product communications [Nat Prod Commun] 2011 Jan; Vol. 6 (1), pp. 67-71.