Zobrazeno 1 - 10
of 38
pro vyhledávání: '"MnSOD, Manganese superoxide dismutase"'
Publikováno v:
Translational Oncology, Vol 17, Iss, Pp 101341-(2022)
Translational Oncology
Translational Oncology
Highlights • Thioredoxin reductase (TrxR), a seleno enzyme, regulates cellular redox. • Several human cancers are known to overexpress TrxR. • Inhibitors of TrxR have enhanced radiation induced cytotoxicity in multiple cancers. • TrxR could b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9aaf62bdf3583fc4416746fca6cdfb01
http://www.sciencedirect.com/science/article/pii/S1936523322000031
http://www.sciencedirect.com/science/article/pii/S1936523322000031
Autor:
Wen-Xing Ding, Hartmut Jaeschke, David S Umbaugh, Olamide B. Adelusi, Giselle Sanchez-Guerrero, Nga T. Nguyen, Jephte Y. Akakpo, Anup Ramachandran
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 12, Pp 3740-3755 (2021)
Acta Pharmaceutica Sinica B, Vol 11, Iss 12, Pp 3740-3755 (2021)
Acetaminophen (APAP) is a widely used analgesic and antipyretic drug, which is safe at therapeutic doses but can cause severe liver injury and even liver failure after overdoses. The mouse model of APAP hepatotoxicity recapitulates closely the human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bde30b76b24a28a9236a78a6ec2b0a30
https://pubmed.ncbi.nlm.nih.gov/35024303
https://pubmed.ncbi.nlm.nih.gov/35024303
Autor:
Sarah A. Hosgood, Kourosh Saeb-Parsy, Michael P. Murphy, Michael L. Nicholson, Hiran A. Prag, Timothy E. Beach, Anja V. Gruszczyk, Krishnaa T. Mahbubani, Margaret M. Huang, Richard C. Hartley, Mazin Hamed, Jack Martin, Laura Pala, Andrew M. James, Angela Logan
Publikováno v:
Redox Biology
Redox Biology, Vol 36, Iss, Pp 101640-(2020)
Redox Biology, Vol 36, Iss, Pp 101640-(2020)
Renal ischemia reperfusion (IR) injury leads to significant patient morbidity and mortality, and its amelioration is an urgent unmet clinical need. Succinate accumulates during ischemia and its oxidation by the mitochondrial enzyme succinate dehydrog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6a428db7cbb67317a1cf4d229c00bb9
http://europepmc.org/articles/PMC7372157
http://europepmc.org/articles/PMC7372157
Autor:
F. Tuccillo, Joseph L. Evans, Antonella Borrelli, Franco M. Buonaguro, Ira D. Goldfine, P. Bonelli, Aldo Mancini
Publikováno v:
Redox Biology, Vol 15, Iss C, Pp 467-479 (2018)
Redox Biology
Redox Biology
Non-alcoholic fatty liver disease (NAFLD) represents the most common chronic liver disease in industrialized countries. NAFLD progresses through the inflammatory phase of non-alcoholic steatohepatitis (NASH) to fibrosis and cirrhosis, with some cases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2419fc2467afc0fef89a4f91dd16f4c
http://www.sciencedirect.com/science/article/pii/S2213231717309291
http://www.sciencedirect.com/science/article/pii/S2213231717309291
Autor:
Dean G. Assimos, Vidhush K. Yarlagadda, Tanecia Mitchell, Vikram Saini, Oreoluwa O. Adedoyin, Ross P. Holmes, Mikita Patel
Publikováno v:
Redox Biology, Vol 15, Iss C, Pp 207-215 (2018)
Redox Biology
Redox Biology
Monocytes/macrophages are thought to be recruited to the renal interstitium during calcium oxalate (CaOx) kidney stone disease for crystal clearance. Mitochondria play an important role in monocyte function during the immune response. We recently det
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32272e9d2d73be509f34657272136c90
http://www.sciencedirect.com/science/article/pii/S2213231717307565
http://www.sciencedirect.com/science/article/pii/S2213231717307565
Autor:
Margaret E. Tome, Ines Batinic-Haberle
Publikováno v:
Redox Biology
Redox Biology, Vol 25, Iss, Pp-(2019)
Redox Biology, Vol 25, Iss, Pp-(2019)
Superoxide dismutases play an important role in human health and disease. Three decades of effort have gone into synthesizing SOD mimics for clinical use. The result is the Mn porphyrins which have SOD-like activity. Several clinical trials are under
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5970862a8aceb3132a79265f6413ed43
http://europepmc.org/articles/PMC6859569
http://europepmc.org/articles/PMC6859569
Autor:
Hideo Suzuki, Fumihiko Uchida, Kiyoji Tanaka, Takeji Sakae, Sechang Oh, Bokun Kim, Takehiko Tsujimoto, Junichi Shoda, Seiichiro Iizumi, Tomonori Isobe
Publikováno v:
JHEP Reports
JHEP Reports, Vol 3, Iss 3, Pp 100253-(2021)
JHEP Reports, Vol 3, Iss 3, Pp 100253-(2021)
Summary Background & Aims A weight-loss-independent beneficial effect of exercise on non-alcoholic fatty liver disease (NAFLD) management has been reported, but the underlying mechanism is unknown. To help determine this mechanism, the effects of exe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d799758e6591ac117326fd2a92b672f8
https://tsukuba.repo.nii.ac.jp/records/2004615
https://tsukuba.repo.nii.ac.jp/records/2004615
Autor:
Ana, Flórido, Nuno, Saraiva, Sara, Cerqueira, Nuno, Almeida, Maddy, Parsons, Ines, Batinic-Haberle, Joana P, Miranda, João G, Costa, Guia, Carrara, Matilde, Castro, Nuno G, Oliveira, Ana S, Fernandes
Publikováno v:
Redox Biology
Manganese(III) porphyrins (MnPs) are superoxide dismutase (SOD) mimics with demonstrated beneficial effects in cancer treatment in combination with chemo- and radiotherapy regimens. Despite the ongoing clinical trials, little is known about the effec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::79cdf41efcd1bda80f9e72b8878732da
https://pubmed.ncbi.nlm.nih.gov/30408752
https://pubmed.ncbi.nlm.nih.gov/30408752
Autor:
D. Neil Granger, Peter R. Kvietys
Publikováno v:
Redox Biology
Reperfusion injury, the paradoxical tissue response that is manifested by blood flow-deprived and oxygen-starved organs following the restoration of blood flow and tissue oxygenation, has been a focus of basic and clinical research for over 4-decades
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0b3520729b589e969c5edc96b3d9b99
http://europepmc.org/articles/PMC4625011
http://europepmc.org/articles/PMC4625011
Autor:
Bo Kong, Wen-Xing Ding, Grace L. Guo, Sharon Manley, Jessica A. Williams, Hong-Min Ni, Luciano DiTacchio
Publikováno v:
Redox Biology, Vol 2, Iss C, Pp 991-1002 (2014)
Redox Biology
Redox Biology
Alcoholic liver disease encompasses a wide spectrum of pathogenesis including steatosis, fibrosis, cirrhosis, and alcoholic steatohepatitis. Autophagy is a lysosomal degradation process that degrades cellular proteins and damaged/excess organelles, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7eadef8f4ec7dcc850a037ebab00cfe1
https://doi.org/10.1016/j.redox.2014.08.007
https://doi.org/10.1016/j.redox.2014.08.007