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Publikováno v:
Biochemical Journal. 384:543-549
Cytokines, phorbol esters, radiation and chemotherapeutic drugs up-regulate the expression of MnSOD (manganese superoxide dismutase). Using the VA-13 cell line, we studied the regulation of SOD2 upon treatment with PMA. Pre-treatment with CHX (cycloh
Autor:
Alam, Faiza1 (AUTHOR), Shahid, Maheen2 (AUTHOR), Riffat, Sumaira3 (AUTHOR), Zulkipli, Ihsan Nazurah1 (AUTHOR), Syed, Fatima4 (AUTHOR), Ashraf, Mussarat2 (AUTHOR), Rehman, Rehana2 (AUTHOR) drrehana7@gmail.com
Publikováno v:
PLoS ONE. 7/10/2023, Vol. 18 Issue 7, p1-13. 13p.
Publikováno v:
Translational Oncology, Vol 17, Iss, Pp 101341-(2022)
Translational Oncology
Translational Oncology
Highlights • Thioredoxin reductase (TrxR), a seleno enzyme, regulates cellular redox. • Several human cancers are known to overexpress TrxR. • Inhibitors of TrxR have enhanced radiation induced cytotoxicity in multiple cancers. • TrxR could b
Autor:
Wen-Xing Ding, Hartmut Jaeschke, David S Umbaugh, Olamide B. Adelusi, Giselle Sanchez-Guerrero, Nga T. Nguyen, Jephte Y. Akakpo, Anup Ramachandran
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 12, Pp 3740-3755 (2021)
Acta Pharmaceutica Sinica B, Vol 11, Iss 12, Pp 3740-3755 (2021)
Acetaminophen (APAP) is a widely used analgesic and antipyretic drug, which is safe at therapeutic doses but can cause severe liver injury and even liver failure after overdoses. The mouse model of APAP hepatotoxicity recapitulates closely the human
Autor:
Sarah A. Hosgood, Kourosh Saeb-Parsy, Michael P. Murphy, Michael L. Nicholson, Hiran A. Prag, Timothy E. Beach, Anja V. Gruszczyk, Krishnaa T. Mahbubani, Margaret M. Huang, Richard C. Hartley, Mazin Hamed, Jack Martin, Laura Pala, Andrew M. James, Angela Logan
Publikováno v:
Redox Biology
Redox Biology, Vol 36, Iss, Pp 101640-(2020)
Redox Biology, Vol 36, Iss, Pp 101640-(2020)
Renal ischemia reperfusion (IR) injury leads to significant patient morbidity and mortality, and its amelioration is an urgent unmet clinical need. Succinate accumulates during ischemia and its oxidation by the mitochondrial enzyme succinate dehydrog
Autor:
F. Tuccillo, Joseph L. Evans, Antonella Borrelli, Franco M. Buonaguro, Ira D. Goldfine, P. Bonelli, Aldo Mancini
Publikováno v:
Redox Biology, Vol 15, Iss C, Pp 467-479 (2018)
Redox Biology
Redox Biology
Non-alcoholic fatty liver disease (NAFLD) represents the most common chronic liver disease in industrialized countries. NAFLD progresses through the inflammatory phase of non-alcoholic steatohepatitis (NASH) to fibrosis and cirrhosis, with some cases
Autor:
Dean G. Assimos, Vidhush K. Yarlagadda, Tanecia Mitchell, Vikram Saini, Oreoluwa O. Adedoyin, Ross P. Holmes, Mikita Patel
Publikováno v:
Redox Biology, Vol 15, Iss C, Pp 207-215 (2018)
Redox Biology
Redox Biology
Monocytes/macrophages are thought to be recruited to the renal interstitium during calcium oxalate (CaOx) kidney stone disease for crystal clearance. Mitochondria play an important role in monocyte function during the immune response. We recently det
Autor:
Margaret E. Tome, Ines Batinic-Haberle
Publikováno v:
Redox Biology
Redox Biology, Vol 25, Iss, Pp-(2019)
Redox Biology, Vol 25, Iss, Pp-(2019)
Superoxide dismutases play an important role in human health and disease. Three decades of effort have gone into synthesizing SOD mimics for clinical use. The result is the Mn porphyrins which have SOD-like activity. Several clinical trials are under
Autor:
Hideo Suzuki, Fumihiko Uchida, Kiyoji Tanaka, Takeji Sakae, Sechang Oh, Bokun Kim, Takehiko Tsujimoto, Junichi Shoda, Seiichiro Iizumi, Tomonori Isobe
Publikováno v:
JHEP Reports
JHEP Reports, Vol 3, Iss 3, Pp 100253-(2021)
JHEP Reports, Vol 3, Iss 3, Pp 100253-(2021)
Summary Background & Aims A weight-loss-independent beneficial effect of exercise on non-alcoholic fatty liver disease (NAFLD) management has been reported, but the underlying mechanism is unknown. To help determine this mechanism, the effects of exe