Carrier-free nanoprodrug for p53-mutated tumor therapy via concurrent delivery of zinc-manganese dual ions and ROS

Autor: Jinping Wang, Chang Qu, Xinyue Shao, Guoqiang Song, Jingyu Sun, Donghong Shi, Ran Jia, Hailong An, Hongjun Wang

Publikováno v: Bioactive Materials, Vol 20, Iss , Pp 404-417 (2023)

Human cancers typically express a high level of tumor-promoting mutant p53 protein (Mutp53) with a minimal level of tumor-suppressing wild-type p53 protein (WTp53). In this regard, inducing Mutp53 degradation while activating WTp53 is a viable strate

Externí odkaz: https://doaj.org/article/1534fc751fce4e0080c4a906f41935da

Carrier-free nanoprodrug for p53-mutated tumor therapy via concurrent delivery of zinc-manganese dual ions and ROS.

Autor: Wang J; Key Laboratory of Molecular Biophysics of Hebei Province, Institute of Biophysics, School of Health Sciences and Biomedical Engineering, Hebei University of Technology, 300401, Tianjin, PR China.; Department of Biomedical Engineering, Stevens Institute of Technology, Hoboken, NJ, 07030, United States., Qu C; Key Laboratory of Molecular Biophysics of Hebei Province, Institute of Biophysics, School of Sciences, Hebei University of Technology, 300401, Tianjin, PR China.; State Key Laboratory of Reliability and Intelligence of Electrical Equipment, School of Electrical Engineering, Hebei University of Technology, Tianjin, 300130, PR China., Shao X; Key Laboratory of Molecular Biophysics of Hebei Province, Institute of Biophysics, School of Sciences, Hebei University of Technology, 300401, Tianjin, PR China., Song G; Key Laboratory of Molecular Biophysics of Hebei Province, Institute of Biophysics, School of Sciences, Hebei University of Technology, 300401, Tianjin, PR China., Sun J; Department of Chemistry and Chemical Biology, Stevens Institute of Technology, Hoboken, NJ, 07030, United States., Shi D; Key Laboratory of Molecular Biophysics of Hebei Province, Institute of Biophysics, School of Sciences, Hebei University of Technology, 300401, Tianjin, PR China.; State Key Laboratory of Reliability and Intelligence of Electrical Equipment, School of Electrical Engineering, Hebei University of Technology, Tianjin, 300130, PR China., Jia R; Key Laboratory of Molecular Biophysics of Hebei Province, Institute of Biophysics, School of Sciences, Hebei University of Technology, 300401, Tianjin, PR China., An H; Key Laboratory of Molecular Biophysics of Hebei Province, Institute of Biophysics, School of Health Sciences and Biomedical Engineering, Hebei University of Technology, 300401, Tianjin, PR China., Wang H; Department of Biomedical Engineering, Stevens Institute of Technology, Hoboken, NJ, 07030, United States.; Department of Chemistry and Chemical Biology, Stevens Institute of Technology, Hoboken, NJ, 07030, United States.; Center for Healthcare Innovation, Stevens Institute of Technology, Hoboken, NJ, 07030, United States.

Publikováno v: Bioactive materials [Bioact Mater] 2022 Jun 18; Vol. 20, pp. 404-417. Date of Electronic Publication: 2022 Jun 18 (Print Publication: 2023).