Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Mlh Vlaming"'
Autor:
E van Duijn, Willem Seinen, T Alves, Mlh Vlaming, Manuel J.T. Carrondo, Dillingh, A Fidder, Cristina Peixoto, Raf de Ligt, Whj Vaes, Ruud Brands, Albert D. Windhorst, MC de Koning, WJ Pasman, Hugo Sandman, N. H. Hendrikse, B.O. Fabriek, J. Burggraaf, Sieto Bosgra, Pam Peeters, Jaj Mocking
Publikováno v:
Clinical Pharmacology & Therapeutics, 98(2), 196-204. Wiley-Blackwell
Clinical pharmacology and therapeutics, 2, 98, 196-204
Vlaming, M L H, van Duijn, E, Dillingh, M R, Brands, R, Windhorst, A D, Hendrikse, N H, Bosgra, S, Burggraaf, J, Koning, M C, Fidder, A, Mocking, J A J, Sandman, H, de Ligt, R A F, Fabriek, B O, Pasman, W J, Seinen, W, Alves, T, Carrondo, M, Peixoto, C, Peeters, P A M & Vaes, W H J 2015, ' Microdosing of a Carbon-14 Labeled Protein in Healthy Volunteers Accurately Predicts Its Pharmacokinetics at Therapeutic Dosages ', Clinical Pharmacology & Therapeutics, vol. 98, no. 2, pp. 196-204 . https://doi.org/10.1002/cpt.131
Clinical pharmacology and therapeutics, 2, 98, 196-204
Vlaming, M L H, van Duijn, E, Dillingh, M R, Brands, R, Windhorst, A D, Hendrikse, N H, Bosgra, S, Burggraaf, J, Koning, M C, Fidder, A, Mocking, J A J, Sandman, H, de Ligt, R A F, Fabriek, B O, Pasman, W J, Seinen, W, Alves, T, Carrondo, M, Peixoto, C, Peeters, P A M & Vaes, W H J 2015, ' Microdosing of a Carbon-14 Labeled Protein in Healthy Volunteers Accurately Predicts Its Pharmacokinetics at Therapeutic Dosages ', Clinical Pharmacology & Therapeutics, vol. 98, no. 2, pp. 196-204 . https://doi.org/10.1002/cpt.131
Preclinical development of new biological entities (NBEs), such as human protein therapeutics, requires considerable expenditure of time and costs. Poor prediction of pharmacokinetics in humans further reduces net efficiency. In this study, we show f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8a65bd50d68b12c68244ff2a9754319
http://resolver.tudelft.nl/uuid:de1d0c5d-f878-4f4a-ac97-74e0d45797a9
http://resolver.tudelft.nl/uuid:de1d0c5d-f878-4f4a-ac97-74e0d45797a9
Autor:
Masmoudi F; Charles River Laboratories, 2333 CR Leiden, The Netherlands.; OrganoVIR Labs, Department of Medical Microbiology, Amsterdam UMC Location Academic Medical Center, Amsterdam Institute for Infection and Immunity, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands., Santos-Ferreira N; Laboratory of Virology and Chemotherapy, KU Leuven-Department of Microbiology, Immunology and Transplantation, Rega Institute, 3000 Leuven, Belgium., Pajkrt D; OrganoVIR Labs, Pediatric Infectious Diseases, Emma Children's Hospital, Amsterdam UMC Location University of Amsterdam, 1105 AZ Amsterdam, The Netherlands., Wolthers KC; OrganoVIR Labs, Department of Medical Microbiology, Amsterdam UMC Location Academic Medical Center, Amsterdam Institute for Infection and Immunity, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands., DeGroot J; Charles River Laboratories, 2333 CR Leiden, The Netherlands., Vlaming MLH; Charles River Laboratories, 2333 CR Leiden, The Netherlands., Rocha-Pereira J; Laboratory of Virology and Chemotherapy, KU Leuven-Department of Microbiology, Immunology and Transplantation, Rega Institute, 3000 Leuven, Belgium., Buti L; Charles River Laboratories, 2333 CR Leiden, The Netherlands.
Publikováno v:
Cells [Cells] 2023 Apr 12; Vol. 12 (8). Date of Electronic Publication: 2023 Apr 12.
Autor:
Mannhardt I; Department of Experimental Pharmacology and Toxicology, Cardiovascular Research Center, University Medical Center Hamburg-Eppendorf, DZHK (German Center for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, 20246 Hamburg, Germany. Electronic address: i.mannhardt@uke.de., Saleem U; Department of Experimental Pharmacology and Toxicology, Cardiovascular Research Center, University Medical Center Hamburg-Eppendorf, DZHK (German Center for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, 20246 Hamburg, Germany., Mosqueira D; Division of Cancer & Stem Cells, University of Nottingham Biodiscovery Institute, University Park, Nottingham NG7 2RD, UK., Loos MF; Department of Experimental Pharmacology and Toxicology, Cardiovascular Research Center, University Medical Center Hamburg-Eppendorf, DZHK (German Center for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, 20246 Hamburg, Germany., Ulmer BM; Department of Experimental Pharmacology and Toxicology, Cardiovascular Research Center, University Medical Center Hamburg-Eppendorf, DZHK (German Center for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, 20246 Hamburg, Germany., Lemoine MD; Department of Cardiology-Electrophysiology, University Heart Center, DZHK (German Center for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, 20246 Hamburg, Germany., Larsson C; Takara Bio Europe AB, 41346 Göteborg, Sweden., Améen C; Takara Bio Europe AB, 41346 Göteborg, Sweden., de Korte T; Ncardia, 2333 BD Leiden, the Netherlands; Department of Anatomy and Embryology, Leiden University Medical Center, 2333 ZD Leiden, The Netherlands., Vlaming MLH; Ncardia, 2333 BD Leiden, the Netherlands., Harris K; GlaxoSmithKline, David Jack Centre for R&D, Park Road, Ware, Hertfordshire, SG12 0DP, UK., Clements P; GlaxoSmithKline, David Jack Centre for R&D, Park Road, Ware, Hertfordshire, SG12 0DP, UK., Denning C; Division of Cancer & Stem Cells, University of Nottingham Biodiscovery Institute, University Park, Nottingham NG7 2RD, UK., Hansen A; Department of Experimental Pharmacology and Toxicology, Cardiovascular Research Center, University Medical Center Hamburg-Eppendorf, DZHK (German Center for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, 20246 Hamburg, Germany., Eschenhagen T; Department of Experimental Pharmacology and Toxicology, Cardiovascular Research Center, University Medical Center Hamburg-Eppendorf, DZHK (German Center for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, 20246 Hamburg, Germany. Electronic address: t.eschenhagen@uke.de.
Publikováno v:
Stem cell reports [Stem Cell Reports] 2020 Oct 13; Vol. 15 (4), pp. 983-998.
Autor:
Saleem U; Department of Experimental Pharmacology and Toxicology, University Medical Center Hamburg Eppendorf, 20246 Hamburg, and DZHK (German Center for Cardiovascular Research), Partner Site, Hamburg/Kiel/Lübeck, Germany., van Meer BJ; Department of Anatomy and Embryology, Leiden University Medical Center, 2333 ZD, Leiden, The Netherlands., Katili PA; Department of Stem Cell Biology, University of Nottingham, University Park, Nottingham NG7 2RD, UK., Mohd Yusof NAN; Department of Stem Cell Biology, University of Nottingham, University Park, Nottingham NG7 2RD, UK., Mannhardt I; Department of Experimental Pharmacology and Toxicology, University Medical Center Hamburg Eppendorf, 20246 Hamburg, and DZHK (German Center for Cardiovascular Research), Partner Site, Hamburg/Kiel/Lübeck, Germany., Garcia AK; Department of Anatomy and Embryology, Leiden University Medical Center, 2333 ZD, Leiden, The Netherlands., Tertoolen L; Department of Anatomy and Embryology, Leiden University Medical Center, 2333 ZD, Leiden, The Netherlands., de Korte T; Department of Anatomy and Embryology, Leiden University Medical Center, 2333 ZD, Leiden, The Netherlands.; Ncardia, 2333 BD, Leiden, The Netherlands., Vlaming MLH; Ncardia, 2333 BD, Leiden, The Netherlands., McGlynn K; Clyde Biosciences Ltd, Biocity Scotland, Newhouse, Lanarkshire ML1 5HU, UK., Nebel J; Department of Experimental Pharmacology and Toxicology, University Medical Center Hamburg Eppendorf, 20246 Hamburg, and DZHK (German Center for Cardiovascular Research), Partner Site, Hamburg/Kiel/Lübeck, Germany., Bahinski A; GlaxoSmithKline, Collegeville, Pennsylvania 19426., Harris K; NC3Rs, London NW1 2BE, UK., Rossman E; GlaxoSmithKline, Collegeville, Pennsylvania 19426., Xu X; GlaxoSmithKline, Collegeville, Pennsylvania 19426., Burton FL; Clyde Biosciences Ltd, Biocity Scotland, Newhouse, Lanarkshire ML1 5HU, UK.; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G12 8QQ, UK., Smith GL; Clyde Biosciences Ltd, Biocity Scotland, Newhouse, Lanarkshire ML1 5HU, UK.; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G12 8QQ, UK., Clements P; GlaxoSmithKline, David Jack Centre for R&D, Ware, Hertfordshire SG12 0DP, UK., Mummery CL; Department of Anatomy and Embryology, Leiden University Medical Center, 2333 ZD, Leiden, The Netherlands.; Department Applied Stem Cell Technologies, University of Twente, 7500 EA Enschede, The Netherlands., Eschenhagen T; Department of Experimental Pharmacology and Toxicology, University Medical Center Hamburg Eppendorf, 20246 Hamburg, and DZHK (German Center for Cardiovascular Research), Partner Site, Hamburg/Kiel/Lübeck, Germany., Hansen A; Department of Experimental Pharmacology and Toxicology, University Medical Center Hamburg Eppendorf, 20246 Hamburg, and DZHK (German Center for Cardiovascular Research), Partner Site, Hamburg/Kiel/Lübeck, Germany., Denning C; Department of Stem Cell Biology, University of Nottingham, University Park, Nottingham NG7 2RD, UK.
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology [Toxicol Sci] 2020 Jul 01; Vol. 176 (1), pp. 103-123.
Autor:
Mulder P; Pluriomics BV, Galileiweg 8, 2333 BD Leiden, The Netherlands., de Korte T; Pluriomics BV, Galileiweg 8, 2333 BD Leiden, The Netherlands. Electronic address: tessa.dekorte@pluriomics.com., Dragicevic E; Nanion Technologies GmbH, Ganghoferstraße 70a, D-80339 Munich, Germany., Kraushaar U; NMI Natural and Medical Sciences Institute, Markwiesenstraße 55, 72770 Reutlingen, Germany., Printemps R; Physiostim, Z.I. de Brénas, 81440, Lautrec, France., Vlaming MLH; Pluriomics BV, Galileiweg 8, 2333 BD Leiden, The Netherlands., Braam SR; Pluriomics BV, Galileiweg 8, 2333 BD Leiden, The Netherlands., Valentin JP; Investigative Toxicology, Non-Clinical Development, UCB-Biopharma, Chemin du Foriest, 1420 Braine l'Alleud, Belgium.
Publikováno v:
Journal of pharmacological and toxicological methods [J Pharmacol Toxicol Methods] 2018 May - Jun; Vol. 91, pp. 36-42. Date of Electronic Publication: 2018 Feb 04.
Autor:
van de Steeg E; 1 TNO , Zeist, the Netherlands ., Läppchen T; 2 Department Minimally Invasive Healthcare, Philips Research , Eindhoven, the Netherlands ., Aguilera B; 3 BioMarin Nederland BV , Leiden, the Netherlands ., Jansen HT; 1 TNO , Zeist, the Netherlands ., Muilwijk D; 3 BioMarin Nederland BV , Leiden, the Netherlands ., Vermue R; 3 BioMarin Nederland BV , Leiden, the Netherlands ., van der Hoorn JW; 1 TNO , Zeist, the Netherlands ., Donato K; 2 Department Minimally Invasive Healthcare, Philips Research , Eindhoven, the Netherlands ., Rossin R; 2 Department Minimally Invasive Healthcare, Philips Research , Eindhoven, the Netherlands ., de Visser PC; 3 BioMarin Nederland BV , Leiden, the Netherlands ., Vlaming MLH; 1 TNO , Zeist, the Netherlands .
Publikováno v:
Nucleic acid therapeutics [Nucleic Acid Ther] 2017 Aug; Vol. 27 (4), pp. 221-231. Date of Electronic Publication: 2017 Apr 18.