Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Mladen Vassilev Tzvetkov"'
Autor:
Michael Grimm, Adrian Rump, Marie-Luise Kromrey, Felix Morof, Camille Dumont, Vincent Jannin, Mladen Vassilev Tzvetkov, Werner Weitschies
Publikováno v:
Pharmaceutics, Vol 15, Iss 11, p 2576 (2023)
Ready-to-fill enteric hard capsule shells are an evolving field of oral drug and nutraceutical products. Lonza Capsugel® Enprotect® capsules were recently proven to provide reliable release in the small intestine after fasted intake, but robustness
Externí odkaz:
https://doaj.org/article/b17e1b020db1404c97cfa1b56c1ea7ce
Autor:
Michael Grimm, Adrian Rump, Lisa Meilicke, Maximilian Feldmüller, Rebecca Keßler, Eberhard Scheuch, Mladen Vassilev Tzvetkov, Werner Weitschies
Publikováno v:
Pharmaceutics, Vol 15, Iss 2, p 328 (2023)
Gastric water emptying as a critical parameter for oral drug absorption can be investigated by several imaging techniques or by the interpretation of pharmacokinetics of appropriate substances. Recently introduced salivary caffeine kinetics is a valu
Externí odkaz:
https://doaj.org/article/43655eb87d1345308934f24ac0b52938
Autor:
Adrian Rump, Marie-Luise Kromrey, Eberhard Scheuch, Vincent Jannin, Lara Rehenbrock, Mladen Vassilev Tzvetkov, Werner Weitschies, Michael Grimm
Publikováno v:
Pharmaceutics, Vol 14, Iss 10, p 1999 (2022)
Many orally dosed APIs are bioavailable only when formulated as an enteric dosage form to protect them from the harsh environment of the stomach. However, an enteric formulation is often accompanied with a higher development effort in the first place
Externí odkaz:
https://doaj.org/article/6a9c42fae777422f8cc17f5817e3fe94
Autor:
Johannes Matthaei, Jürgen Brockmöller, Werner Steimer, Konstanze Pischa, Stefan Leucht, Maria Kullmann, Ole Jensen, Typhaine Ouethy, Mladen Vassilev Tzvetkov, Muhammad Rafehi
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
The tricyclic antidepressant amitriptyline is frequently prescribed but its use is limited by its narrow therapeutic range and large variation in pharmacokinetics. Apart from interindividual differences in the activity of the metabolising enzymes cyt
Externí odkaz:
https://doaj.org/article/9ae58c175f44436db83dbd9a1c9a18d2
Autor:
Johannes Matthaei, Wagner Hugo Bonat, Reinhold Kerb, Mladen Vassilev Tzvetkov, Jakob Strube, Stefanie Brunke, Cordula Sachse-Seeboth, Daniel Sehrt, Ute Hofmann, Jacob von Bornemann Hjelmborg, Matthias Schwab, Jürgen Brockmöller
Publikováno v:
Frontiers in Genetics, Vol 11 (2020)
Human CYP3A enzymes (including CYP3A4 and CYP4A5) metabolize about 40% of all drugs and numerous other environmental and endogenous substances. CYP3A activity is highly variable within and between humans. As a consequence, therapy with standard doses
Externí odkaz:
https://doaj.org/article/06cfdc1c43bd47929668ebb95020f727
Publikováno v:
PLoS ONE, Vol 12, Iss 12, p e0189521 (2017)
Ranitidine (Zantac®) is a H2-receptor antagonist commonly used for the treatment of acid-related gastrointestinal diseases. Ranitidine was reported to be a substrate of the organic cation transporters OCT1 and OCT2. The hepatic transporter OCT1 is h
Externí odkaz:
https://doaj.org/article/c483c50f0fcd4e85b32d1b58bccc2850
Publikováno v:
Trends in Pharmacological Sciences.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::51ee6cc8c43a1071fd6c8d2c67b365c2
https://doi.org/10.1016/j.tips.2023.04.001
https://doi.org/10.1016/j.tips.2023.04.001
Autor:
Marleen Julia Meyer, Simon Falk, Sarah Römer, Clarissa Prinzinger, Sabine Tacke, Joachim Geyer, Stefan Simm, Mladen Vassilev Tzvetkov
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 9; Pages: 5100
OCT1 and OCT2 are polyspecific membrane transporters that are involved in hepatic and renal drug clearance in humans and mice. In this study, we cloned dog OCT1 and OCT2 and compared their function to the human and mouse orthologs. We used liver and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baa495b17f0300721829b53eeaaee83b