Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Mladen Jokic"'
Autor:
Judith E. Spiro, Miriam Rinneburger, Dennis M. Hedderich, Mladen Jokic, Hans Christian Reinhardt, David Maintz, Moritz Palmowski, Thorsten Persigehl
Publikováno v:
European Radiology Experimental, Vol 4, Iss 1, Pp 1-8 (2020)
Abstract Background Compared to histology-based methods, imaging can reduce animal usage in preclinical studies. However, availability of dedicated scanners is limited. We evaluated clinical computed tomography (CT) and magnetic resonance imaging (MR
Externí odkaz:
https://doaj.org/article/24cccb4d9afe42719e960ce368ac7730
Autor:
Christiane Kümpers, Mladen Jokic, Ozan Haase, Anne Offermann, Wenzel Vogel, Victoria Grätz, Ewan A. Langan, Sven Perner, Patrick Terheyden
Publikováno v:
Frontiers in Medicine, Vol 6 (2019)
Immune checkpoint inhibition has resulted in dramatic improvements in overall and relapse-free survival in patients with metastatic melanoma. The most commonly used immune checkpoint inhibitors are monoclonal antibodies targeting programmed cell deat
Externí odkaz:
https://doaj.org/article/c4f779f87c694e45a8cb4218e32e5454
Autor:
H. Christian Reinhardt, Lukas C. Heukamp, Winfried Edelmann, Johanna van Oers, Uschi Leeser, Gero Knittel, Laura Ivan, Ron D. Jachimowicz, Mladen Jokic, Lisa Thelen, Felix Dietlein
PDF file 129K, Supplementary Methods provide additional information on experimental techniques and data analysis. Supplementary Legends describe supplementary figures S1-S10 and supplementary table S1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75160b20592e9f67b8aba646ceb3a10a
https://doi.org/10.1158/2159-8290.22529808
https://doi.org/10.1158/2159-8290.22529808
Autor:
H. Christian Reinhardt, Lukas C. Heukamp, Winfried Edelmann, Johanna van Oers, Uschi Leeser, Gero Knittel, Laura Ivan, Ron D. Jachimowicz, Mladen Jokic, Lisa Thelen, Felix Dietlein
PDF file 3500K, Potency of KU60648 across 94 cancer cell lines (Figure S1), comparison of KU60648-sensitivity in mutant vs. wildtype lines for 9 exemplary DNA repair-associated genes (Figure S2), MSH3 variants and Sanger sequencing of BRCA1 (Figure S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3db39079aecdda6f5c42924ff6abace2
https://doi.org/10.1158/2159-8290.22529814.v1
https://doi.org/10.1158/2159-8290.22529814.v1
Autor:
H. Christian Reinhardt, Lukas C. Heukamp, Winfried Edelmann, Johanna van Oers, Uschi Leeser, Gero Knittel, Laura Ivan, Ron D. Jachimowicz, Mladen Jokic, Lisa Thelen, Felix Dietlein
PDF file 37K, List of all cell lines included in this study. Cell line name, GI50 of KU60648 from initial cell line screen, sensitivity classification as well as mutation annotation source are recorded
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0a8406a03aac1a7c1207c55c27a0013
https://doi.org/10.1158/2159-8290.22529811.v1
https://doi.org/10.1158/2159-8290.22529811.v1
Autor:
Sebastian Marwitz, Anne Offermann, Anke Fähnrich, Mark P. Kühnel, Sven Perner, Mladen Jokic, Christiane Kümpers, Carsten Heidel, Helen Pasternack, Sabine Bohnet, Ignacija Vlasic, Jutta Kirfel, Hauke Busch, Torsten Goldmann, Danny Jonigk
Publikováno v:
Cancers
Volume 13
Issue 18
Cancers, Vol 13, Iss 4562, p 4562 (2021)
Volume 13
Issue 18
Cancers, Vol 13, Iss 4562, p 4562 (2021)
Background: Lung cancer is the most frequent cause of cancer-related deaths worldwide. The clinical development of immune checkpoint blockade has dramatically changed the treatment paradigm for patients with lung cancer. Yet, an improved understandin
Autor:
Moritz Palmowski, David Maintz, Thorsten Persigehl, Hans Christian Reinhardt, Judith E. Spiro, Mladen Jokic, Miriam Rinneburger, Dennis M. Hedderich
Publikováno v:
European Radiology Experimental
European Radiology Experimental, Vol 4, Iss 1, Pp 1-8 (2020)
European Radiology Experimental, Vol 4, Iss 1, Pp 1-8 (2020)
Background Compared to histology-based methods, imaging can reduce animal usage in preclinical studies. However, availability of dedicated scanners is limited. We evaluated clinical computed tomography (CT) and magnetic resonance imaging (MRI) in com
Autor:
Arina Riabinska, Miriam Rinneburger, Wenzel Vogel, Alexandra Florin, Mehmet Akyüz, Björn Schumacher, Reinhard Büttner, Christian Fritz, Sebastian Michels, Christiane Kümpers, Jürgen Thomale, David Maintz, Sven Perner, Mladen Jokic, Anne Offermann, Luka Ozretić, Maike Wittersheim, Thorsten Persigehl, Niklas Klümper, Anna Schmitt, Judith Eva Spiro, Michael Nowak, Martin Erkel, Hans Christian Reinhardt, Ignacija Vlasic, Jürgen Wolf, Daniela Welcker
Publikováno v:
Molecular Cancer Research. 14:1110-1123
KRAS-mutant lung adenocarcinoma is among the most common cancer entities and, in advanced stages, typically displays poor prognosis due to acquired resistance against chemotherapy, which is still largely based on cisplatin-containing combination regi
Autor:
Mladen Jokic, Petar Papic, Boris Vakanjac, Radisav Golubovic, Vesna Ristic-Vakanjac, Marina Cokorilo-Ilic
Publikováno v:
Zbornik Radova: Geografski institut "Jovan Cvijić", Vol 65, Iss 1, Pp 19-32 (2015)
Zbornik Radova: Geografski institut "Jovan Cvijić", Vol 65, Iss 1 (2015)
Zbornik Radova: Geografski institut "Jovan Cvijić", Vol 65, Iss 1 (2015)
Detailed hydrological and hydrogeological assessments of karst spring discharge require information about the groundwater regime in the study area/watershed. However, groundwater regime monitoring is often organized locally and sporadically, as requi
Autor:
Maurizio Fanciulli, Mladen Jokic, Katja Höpker, Anna Schmitt, Reinhard Büttner, Bernhard Schermer, Safiya Khurshid, Carien M. Niessen, Maike Wittersheim, Judith Eva Spiro, Martin Höhne, Daniela Welcker, Thorsten Persigehl, Hans Christian Reinhardt, Peter Frommolt, Thomas Benzing, Manaswita Jain
Publikováno v:
Oncogene. 37(11)
A fundamental principle in malignant tranformation is the ability of cancer cells to escape the naturally occurring cell-intrinsic responses to DNA damage. Tumors progress despite the accumulation of DNA lesions. However, the underlying mechanisms of