Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Mladen I. Yovchev"'
Publikováno v:
Hepatology Communications, Vol 3, Iss 8, Pp 1137-1150 (2019)
Because of their high regenerative potential, stem cells are an ideal resource for development of therapies that replace injured tissue mass and restore function in patients with end‐stage liver diseases. Using a rat model of bile duct ligation (BD
Externí odkaz:
https://doaj.org/article/91df9d2d8a494f7a89398a300dd2eddd
Autor:
Sabreen Megherhi, Srividyameena Haridoss, Michael Oertel, Joseph Locker, Hannah Schweizer, Maria Beecher, Mladen I. Yovchev
Publikováno v:
Hepatology Communications
Activin A, a multifunctional cytokine, plays an important role in hepatocyte growth suppression and is involved in liver size control. The present study was aimed to determine the cell location of activin A in the normal rat liver microenvironment an
Autor:
Yoshitaka Miyagawa, Hideo Baba, Kyle Sylakowski, Jing Yang, Satdarshan P.S. Monga, Mladen I. Yovchev, Kari Nejak-Bowen, Michael D. Thompson, Hirohisa Okabe, Shanmugam Nagarajan, Maria Chikina, Michael Oertel
Publikováno v:
Hepatology. 64:1652-1666
Hepatic repair is directed chiefly by the proliferation of resident mature epithelial cells. Furthermore, if predominant injury is to cholangiocytes, the hepatocytes can transdifferentiate to cholangiocytes to assist in the repair and vice versa, as
Autor:
Hiroshi Yagi, Angus W. Thomson, Alejandro Soto-Gutierrez, Yoshihiro Ono, Alexandra Collin de l'Hortet, Kentaro Matsubara, Shinichiro Yokota, Michael Oertel, David A. Geller, Mladen I. Yovchev, Kan Handa, Jorge Guzman-Lepe, Angelica Perez-Gutierrez
Publikováno v:
Transplantation. 101(1)
BACKGROUND Auxiliary partial liver transplantation (APLT) in humans is a therapeutic modality used especially to treat liver failure in children or congenital metabolic disease. Animal models of APLT have helped to explore therapeutic options. Though
Autor:
Mladen I, Yovchev, Michael, Oertel
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1506
Liver transplantation is the only therapeutic treatment for patients with end-stage liver diseases. However, donor organ scarcity is the major limitation, and therefore, alternative strategies are urgently needed. The ultimate goal for successful cel
Autor:
Mladen I. Yovchev, Michael Oertel
Publikováno v:
Methods in Molecular Biology ISBN: 9781493965045
Liver transplantation is the only therapeutic treatment for patients with end-stage liver diseases. However, donor organ scarcity is the major limitation, and therefore, alternative strategies are urgently needed. The ultimate goal for successful cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1eea25095d251c5a35e16da9cc62312d
https://doi.org/10.1007/978-1-4939-6506-9_7
https://doi.org/10.1007/978-1-4939-6506-9_7
Publikováno v:
Hepatology. 59:284-295
Considerable progress has been made in developing antifibrotic agents and other strategies to treat liver fibrosis; however, significant long-term restoration of functional liver mass has not yet been achieved. Therefore, we investigated whether tran
Autor:
Marius Sudol, Liang Zhu, David A. Shafritz, Mladen I. Yovchev, Mariana D. Dabeva, Fadi Luc Jaber, Zhonglei Lu, John W. Murray, Joseph Locker, Shachi Patel, Leslie E. Rogler
Publikováno v:
Scientific Reports
Liver repopulation by transplanted hepatocytes has not been achieved previously in a normal liver microenvironment. Here we report that adult rat hepatocytes transduced ex vivo with a lentivirus expressing a human YapERT2 fusion protein (hYapERT2) un
Publikováno v:
Journal of hepatology. 64(6)
Background & Aims Current research focuses on developing alternative strategies to restore decreased liver mass prior to the onset of end-stage liver disease. Cell engraftment/repopulation requires regeneration in normal liver, but we have shown that
Publikováno v:
Laboratory Investigation. 86:1272-1284
Glypican-3 (Gpc3), a cell surface-linked heparan sulfate proteoglycan is highly expressed during embryogenesis and is involved in organogenesis. Its exact biological function remains unknown. We have studied the expression of Gpc3 in fetal and adult