Intraepithelial Lymphocytes in Human Gut Have Lytic Potential and a Cytokine Profile That Suggest T Helper 1 and Cytotoxic Functions

Autor: Lundqvist C, silvia melgar, Mm, Yeung, Hammarström S, Ml, Hammarström

Publikováno v: Scopus-Elsevier
Europe PubMed Central

The functional properties of intraepithelial lymphocytes (IEL) in normal human jejunum, ileum, and colon were investigated. Cytokine mRNA expression in IEL and enterocytes was determined by reverse transcriptase-PCR and IFN-gamma+ IEL by immunohistoc

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qRT-PCR analysis of CEACAM5, KLK6, SLC35D3, MUC2 and POSTN in colon cancer lymph nodes-An improved method for assessment of tumor stage and prognosis.

Autor: Lindmark G; Department of Clinical Sciences, Lund University, Helsingborg, Sweden.; Specialistläkarna, Malmö, Sweden., Olsson L; HiloProbe AB, Umeå, Sweden., Sitohy B; Department of Clinical Microbiology, Umeå University, Umeå, Sweden.; Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden., Israelsson A; Department of Clinical Microbiology, Umeå University, Umeå, Sweden., Blomqvist J; HiloProbe AB, Umeå, Sweden., Kero S; HiloProbe AB, Umeå, Sweden., Roshdy T; Department of Clinical Microbiology, Umeå University, Umeå, Sweden.; Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden.; Department of Molecular Biology, Genetic Engineering, and Biotechnology Research Institute, University of Sadat City, Sadat City, Menoufia, Egypt., Söderholm M; Department of Surgery, Blekinge Hospital, Karlskrona, Sweden., Turi A; Department of Clinical Pathology and Cytology, Blekinge Hospital, Karlskrona, Sweden., Isaksson J; Department of Clinical Pathology and Cytology, Blekinge Hospital, Karlskrona, Sweden., Sakari T; Department of Surgical Sciences, Uppsala University Hospital, Uppsala, Sweden.; Department of Surgery, Gävle Hospital, Gävle, Sweden., Dooper M; Department of Clinical Pathology and Cytology, Gävle Hospital, Gävle, Sweden., Dafnis G; Colorectal Unit, Department of Surgery and Urology, Mälarsjukhuset, Eskilstuna, Sweden., Forsberg P; Unilabs, Clinical Pathology and Cytology, Mälarsjukhuset, Eskilstuna, Sweden., Skovsted S; Unit for Surgery, Örnsköldsvik Hospital, Örnsköldsvik, Sweden., Walldén M; Centrum for Surgery, Sundsvall Hospital, Sundsvall, Sweden., Kung CH; Department of Surgical and Perioperative Sciences, Surgery, Umeå University, Umeå, Sweden.; Department of Surgery, Skellefteå Hospital, Skellefteå, Sweden., Rutegård M; Department of Surgical and Perioperative Sciences, Surgery, Umeå University, Umeå, Sweden.; Wallenberg Centre for Molecular Medicine, Umeå University, Umeå, Sweden., Nordmyr J; Department of Clinical Pathology, Linköping University Hospital, Linköping, Sweden., Muhrbeck M; Department of Surgery in Norrköping, Linköping University, Norrköping, Sweden.; Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden., Hammarström S; Department of Clinical Microbiology, Umeå University, Umeå, Sweden., Hammarström ML; Department of Clinical Microbiology, Umeå University, Umeå, Sweden.

Publikováno v: International journal of cancer [Int J Cancer] 2024 Feb 01; Vol. 154 (3), pp. 573-584. Date of Electronic Publication: 2023 Sep 12.

DNA sensor-associated type I interferon signaling is increased in ulcerative colitis and induces JAK-dependent inflammatory cell death in colonic organoids.

Autor: Flood P; APC Microbiome Ireland, University College Cork, Cork, Ireland., Fanning A; APC Microbiome Ireland, University College Cork, Cork, Ireland., Woznicki JA; APC Microbiome Ireland, University College Cork, Cork, Ireland., Crowley T; APC Microbiome Ireland, University College Cork, Cork, Ireland., Christopher A; APC Microbiome Ireland, University College Cork, Cork, Ireland., Vaccaro A; APC Microbiome Ireland, University College Cork, Cork, Ireland., Houston A; APC Microbiome Ireland, University College Cork, Cork, Ireland.; Department of Medicine, University College Cork, Cork, Ireland., McSweeney S; APC Microbiome Ireland, University College Cork, Cork, Ireland., Ross S; APC Microbiome Ireland, University College Cork, Cork, Ireland., Hogan A; APC Microbiome Ireland, University College Cork, Cork, Ireland., Brint E; APC Microbiome Ireland, University College Cork, Cork, Ireland.; Department of Pathology, Cork University Hospital, University College Cork, Clinical Sciences Building, Cork, Ireland., Skowyra A; APC Microbiome Ireland, University College Cork, Cork, Ireland., Bustamante M; APC Microbiome Ireland, University College Cork, Cork, Ireland., Ambrose M; APC Microbiome Ireland, University College Cork, Cork, Ireland., Moloney G; APC Microbiome Ireland, University College Cork, Cork, Ireland., MacSharry J; APC Microbiome Ireland, University College Cork, Cork, Ireland.; School of Microbiology, University College Cork, Cork, Ireland.; School of Medicine, University College Cork, Cork, Ireland., Hammarström ML; Section of Infection and Immunology, Department of Clinical Microbiology, Umeå University, Umeå, Sweden., Hurley M; APC Microbiome Ireland, University College Cork, Cork, Ireland.; Department of Medicine, University College Cork, Cork, Ireland., Fitzgibbons C; APC Microbiome Ireland, University College Cork, Cork, Ireland., Quigley EMM; APC Microbiome Ireland, University College Cork, Cork, Ireland., Shanahan F; APC Microbiome Ireland, University College Cork, Cork, Ireland.; Department of Medicine, University College Cork, Cork, Ireland., Zulquernain SA; APC Microbiome Ireland, University College Cork, Cork, Ireland.; Department of Medicine, University College Cork, Cork, Ireland., McCarthy J; Department of Gastroenterology, Mercy University Hospital, Cork, Ireland., Dodson GS; Second Genome, Brisbane, California., Dabbagh K; Second Genome, Brisbane, California., McRae BL; Immunology Discovery, Abbvie Bioresearch Center, Worcester, Massachusetts., Melgar S; APC Microbiome Ireland, University College Cork, Cork, Ireland., Nally K; APC Microbiome Ireland, University College Cork, Cork, Ireland.; School of Biochemistry and Cell Biology, University College Cork, Cork, Ireland.

Publikováno v: American journal of physiology. Gastrointestinal and liver physiology [Am J Physiol Gastrointest Liver Physiol] 2022 Nov 01; Vol. 323 (5), pp. G439-G460. Date of Electronic Publication: 2022 Sep 27.

Clinical Significance of Stem Cell Biomarkers EpCAM, LGR5 and LGR4 mRNA Levels in Lymph Nodes of Colon Cancer Patients.

Autor: AbdelMageed M; Department of Clinical Microbiology, Infection and Immunology, Umeå University, SE-90185 Umeå, Sweden.; Department of Radiation Sciences, Oncology, Umeå University, SE-90185 Umeå, Sweden.; Department of Pathology, Faculty of Veterinary Medicine, Zagazig University, Zagazig 44511, Egypt., Ismail HTH; Department of Clinical Microbiology, Infection and Immunology, Umeå University, SE-90185 Umeå, Sweden.; Department of Radiation Sciences, Oncology, Umeå University, SE-90185 Umeå, Sweden.; Department of Clinical Pathology, Faculty of Veterinary Medicine, Zagazig University, Zagazig 44511, Egypt., Olsson L; Department of Clinical Microbiology, Infection and Immunology, Umeå University, SE-90185 Umeå, Sweden., Lindmark G; Institution of Clinical Sciences, Lund University, SE-25187 Helsingborg, Sweden., Hammarström ML; Department of Clinical Microbiology, Infection and Immunology, Umeå University, SE-90185 Umeå, Sweden., Hammarström S; Department of Clinical Microbiology, Infection and Immunology, Umeå University, SE-90185 Umeå, Sweden., Sitohy B; Department of Clinical Microbiology, Infection and Immunology, Umeå University, SE-90185 Umeå, Sweden.; Department of Radiation Sciences, Oncology, Umeå University, SE-90185 Umeå, Sweden.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2021 Dec 30; Vol. 23 (1). Date of Electronic Publication: 2021 Dec 30.

Evaluating macrophage migration inhibitory factor 1 expression as a prognostic biomarker in colon cancer.

Autor: Olsson L; Department of Clinical Microbiology, Immunology, Umeå University, Umeå, Sweden., Lindmark G; Department of Surgery, Lund University, Helsingborg, Sweden., Hammarström ML; Department of Clinical Microbiology, Immunology, Umeå University, Umeå, Sweden., Hammarström S; Department of Clinical Microbiology, Immunology, Umeå University, Umeå, Sweden., Sitohy B; Department of Clinical Microbiology, Immunology, Umeå University, Umeå, Sweden.; Division of Oncology, Department of Radiation Sciences, Umeå University, Umeå, Sweden.

Publikováno v: Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine [Tumour Biol] 2020 Jun; Vol. 42 (6), pp. 1010428320924524.