Zobrazeno 1 - 10 of 55 pro vyhledávání: '"Ml, Bath"'
1
Transcriptional regulation of vav, a gene expressed throughout the hematopoietic compartment
Autor: Ogilvy S, Ag, Elefanty, Visvader J, Ml, Bath, Aw, Harris, Jerry Adams
Publikováno v: Europe PubMed Central
The vav gene is expressed in all hematopoietic but few other cell types. To explore its unusual compartment-wide regulation, we cloned the murine gene, sequenced its promoter region, identified DNase I hypersensitive (HS) sites in the chromatin, and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::99993abb41fa1636ef5eb1eeef85b0a1
https://pubmed.ncbi.nlm.nih.gov/9427694
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2
Perturbed development of T and B cells in mice expressing an Hlx homeobox transgene
Autor: Jd, Allen, Aw, Harris, Ml, Bath, Andreas Strasser, Scollay R, Jm, Adams
Publikováno v: Europe PubMed Central
Within the lymphoid compartment of mice, the Hlx homeobox gene is expressed only at early stages of B-lymphoid differentiation. To determine whether Hlx influences lymphopoiesis, transgenic mice were developed to enforce Hlx expression throughout the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::dc35d5897e2eaa7eeeea12e7826e92d3
https://pubmed.ncbi.nlm.nih.gov/7836739
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3
bmi-1 transgene induces lymphomas and collaborates with myc in tumorigenesis
Autor: Haupt Y, Ml, Bath, Aw, Harris, Jerry Adams
Publikováno v: Europe PubMed Central
The bmi-1 gene was discovered as a frequent target of Moloney virus insertion in virally accelerated B-lymphoid tumors of E mu-myc transgenic mice and hence is thought to collaborate with the myc gene in lymphomagenesis, but its oncogenic potential h
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::e93396af291106aeeec3465f7df28825
http://europepmc.org/abstract/med/8414519
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7
Promoter elements of vav drive transgene expression in vivo throughout the hematopoietic compartment
Autor: Ogilvy S, Metcalf D, Gibson L, Ml, Bath, Aw, Harris, Jerry Adams
Publikováno v: Europe PubMed Central
To develop a method for targeting expression of genes to the full hematopoietic system, we have used transgenic mice to explore the transcriptional regulation of the vav gene, which is expressed throughout this compartment but rarely outside it. Prev
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::c83c640ec764b40b0f96c8a11708a24c
http://europepmc.org/abstract/med/10477714
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8
Overexpressed max is not oncogenic and attenuates myc-induced lymphoproliferation and lymphomagenesis in transgenic mice
Autor: Gj, Lindeman, Aw, Harris, Ml, Bath, Rn, Eisenman, Jerry Adams
Publikováno v: Europe PubMed Central
The cellular growth promoting function of the Myc oncoprotein requires its heterodimerization with the Max protein, but Max can also form complexes that inhibit Myc action. To determine whether max overexpression in vivo is oncogenic and whether it c
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::2b085607285f9cbe5ba451d058adfe1e
http://europepmc.org/abstract/med/7898919
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10
Lessons from bcl-2 transgenic mice for immunology, cancer biology and cell death research
Autor: Andreas Strasser, O'Connor L, Dc, Huang, Reilly La, O., Ml, Stanley, Ml, Bath, Jm, Adams, Cory S, Aw, Harris
Publikováno v: Europe PubMed Central
The protein product of the proto-oncogene bcl-2, originally discovered by virtue of its chromosomal translocation in human follicular centre B cell lymphoma, is a physiological inhibitor of programmed cell death, apoptosis. Initial studies in transge
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::87a61b0f1f56941413e10488368b2979
http://europepmc.org/abstract/med/8950469
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