Inflammatory cytokines provide a third signal for activation of naive CD4+ and CD8+ T cells

Autor: Jm, Curtsinger, Cs, Schmidt, anna mondino, Dc, Lins, Rm, Kedl, Mk, Jenkins, Mf, Mescher

Publikováno v: Europe PubMed Central

The effects of inflammatory cytokines on naive T cells have been studied using MHC protein/peptide complexes on microspheres, thus avoiding the use of APCs whose functions may be affected by the cytokines. IL-1, but not IL-12, increased proliferation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::7247eee7c6b7ce12f7b2d04895a9166f
https://pubmed.ncbi.nlm.nih.gov/10092777

Induction and maintenance of anergy in mature T cells

Autor: Mk, Jenkins, Mueller D, Rh, Schwartz, Simon Carding, Bottomley K, Mj, Stadecker, Kb, Urdahl, Sd, Norton

Publikováno v: Europe PubMed Central

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::6376216f95e58abed2f182bc17eca472
https://pubmed.ncbi.nlm.nih.gov/1950767

Effects of cyclosporine A on T cell development and clonal deletion

Autor: MK Jenkins, RH Schwartz, DM Pardoll

Publikováno v: Science (New York, N.Y.). 241(4873)

Cyclosporine A (CsA) is an important immunosuppressive drug that is widely used in transplantation medicine. Many of its suppressive effects on T cells appear to be related to the inhibition of T cell receptor (TCR)-mediated activation events. Parado

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcfbd461e58194eb24e4d5fec59e9f8d
https://pubmed.ncbi.nlm.nih.gov/3262237

Defective transcription of the IL-2 gene is associated with impaired expression of c-Fos, FosB, and JunB in anergic T helper 1 cells

Autor: anna mondino, Cd, Whaley, Dr, Desilva, Li W, Mk, Jenkins, Dl, Mueller

Publikováno v: Europe PubMed Central

Anergic CD4+ Th cells do not produce IL-2 when challenged with Ag-pulsed accessory cells because of a transcriptional defect. In this work, we report that these anergic T cells are defective in their ability to up-regulate protein binding and transac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::571f018c99d8202b14ffb1e43682db20
http://europepmc.org/abstract/med/8757326

The CD4+ T cell repertoire specific for citrullinated peptides shows evidence of immune tolerance.

Autor: McElwee MK; Center for Immunology, University of Minnesota Medical School , Minneapolis, MN, USA.; Division of Rheumatic and Autoimmune Diseases, Department of Medicine, University of Minnesota Medical School, Minneapolis, MN, USA., Dileepan T; Center for Immunology, University of Minnesota Medical School , Minneapolis, MN, USA.; Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, MN, USA., Mahmud SA; Center for Immunology, University of Minnesota Medical School , Minneapolis, MN, USA.; Division of Pediatric Rheumatology, Allergy and Immunology, Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN, USA., Jenkins MK; Center for Immunology, University of Minnesota Medical School , Minneapolis, MN, USA.; Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.

Publikováno v: The Journal of experimental medicine [J Exp Med] 2023 Dec 04; Vol. 220 (12). Date of Electronic Publication: 2023 Oct 13.