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Analysis of the multiple interactions between IL-12 and the high affinity IL-12 receptor complex

Autor: Dh, Presky, Lj, Minetti, Silke Gillessen, Vl, Wilkinson, Cy, Wu, Gubler U, Chizzonite R, Mk, Gately

Publikováno v: Europe PubMed Central

IL-12 is a heterodimeric cytokine, composed of a p40 and a p35 subunit, that exerts its biological effects by binding to specific cell surface receptors. Two IL-12R proteins, designated human IL-12 (huIL-12) receptor beta1 (huIL-12Rbeta1) and huIL-12

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::373c706583af53a1462b8878726aabfa
https://pubmed.ncbi.nlm.nih.gov/9498755

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IL-12 protects immunocompetent and immunodeficient neonatal mice against infection with Cryptosporidium parvum

Autor: Joseph Urban, Fayer R, Sj, Chen, Wc, Gause, Mk, Gately, Fd, Finkelman

Publikováno v: Europe PubMed Central

The protozoan parasite Cryptosporidium parvum (Cp) causes diarrhea that can be acutely severe in immunocompetent persons and can become chronic and life-threatening in immunocompromised individuals. Because studies in mice have implicated IFN-gamma i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::f230a373ec26939dda367637b205fcc1
https://pubmed.ncbi.nlm.nih.gov/8598471

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In vitro maturation of neonatal human CD8 T lymphocytes into IL-4- and IL-5-producing cells

Autor: Dg, Byun, Christian E. Demeure, Lp, Yang, Shu U, Ishihara H, Vezzio N, Mk, Gately, Delespesse G

Publikováno v: Europe PubMed Central

Naive CD8 T cells isolated from umbilical cord blood were examined for cytokine production and for surface phenotype before and after priming with anti-CD3 mAb in the presence of selected cytokines. On stimulation with anti-CD3 immobilized on CD32-B7

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::be29657048fa90dccfeda7a676bba005
https://pubmed.ncbi.nlm.nih.gov/7963550

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IL-12 regulates T helper type 1 cytokine responses in human infectious disease

Autor: PA Sieling, X Wang, MK Gately, JL Oliveros, T McHugh, PF Barnes, SF Wolf, L Golkar, M Yamamura, Y Yogi, K Uyemura, TH Rea, RL Modlin

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 153(8)

We investigated the role of IL-12 in regulating T cell and cytokine responses in human infectious disease by using the spectrum of leprosy as a model. Tuberculoid patients mount strong T cell responses to Mycobacterium leprae, with production of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8212585dfe48b71c149cefa3c89c5d15
https://pubmed.ncbi.nlm.nih.gov/7930584

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Hydrocortisone suppresses the generation of nonspecific 'anomalous' killers but not specific cytolytic T lymphocytes in human mixed lymphocyte-tumor cultures

Autor: LM Muul, MK Gately

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 132(3)

Interpretation of results with the use of effector populations generated in human mixed lymphocyte tumor cultures (MLTC) has in many cases been clouded by the presence of two distinct cytolytic effectors: specific cytolytic T lymphocytes (CTL) and no

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a52e84f7f97b93d08cedd3cd6e98a67
https://pubmed.ncbi.nlm.nih.gov/6198383

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