A high frequency of circulating B cells share clonotypic Ig heavy-chain VDJ rearrangements with autologous bone marrow plasma cells in multiple myeloma, as measured by single-cell and in situ reverse transcriptase-polymerase chain reaction

Autor: Agnieszka Szczepek, Seeberger K, Wizniak J, Mj, Mant, Ar, Belch, Lm, Pilarski

Publikováno v: Europe PubMed Central

In multiple myeloma (MM), the VDJ rearrangement of the immunoglobulin heavy chain expressed by MM plasma cells provides a unique clonotypic marker. Although clonotypic MM cells have been found in the circulation, their number has been controversial.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::ccc99d1ed9c91b4b45b62ff24bae5475
http://europepmc.org/abstract/med/9763569

Inherited polymorphisms in hyaluronan synthase 1 predict risk of systemic B-cell malignancies but not of breast cancer.

Autor: Kuppusamy H; University of Alberta and Cross Cancer Institute, Edmonton, Alberta, Canada., Ogmundsdottir HM; University of Iceland, Reykjavik, Iceland., Baigorri E; University of Alberta and Cross Cancer Institute, Edmonton, Alberta, Canada., Warkentin A; University of Alberta and Cross Cancer Institute, Edmonton, Alberta, Canada., Steingrimsdottir H; Landspitali University Hospital, Reykjavik, Iceland., Haraldsdottir V; Landspitali University Hospital, Reykjavik, Iceland., Mant MJ; University of Alberta and Cross Cancer Institute, Edmonton, Alberta, Canada., Mackey J; University of Alberta and Cross Cancer Institute, Edmonton, Alberta, Canada., Johnston JB; Dept. of Hematology, Cancer Care Manitoba and the University of Manitoba, Winnipeg, Manitoba, Canada., Adamia S; Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America., Belch AR; University of Alberta and Cross Cancer Institute, Edmonton, Alberta, Canada., Pilarski LM; University of Alberta and Cross Cancer Institute, Edmonton, Alberta, Canada.

Publikováno v: PloS one [PLoS One] 2014 Jun 20; Vol. 9 (6), pp. e100691. Date of Electronic Publication: 2014 Jun 20 (Print Publication: 2014).

Inherited and acquired variations in the hyaluronan synthase 1 (HAS1) gene may contribute to disease progression in multiple myeloma and Waldenstrom macroglobulinemia.

Autor: Adamia S; Departments of Oncology, University of Alberta, Cross Cancer Institute, Edmonton, AB., Reichert AA, Kuppusamy H, Kriangkum J, Ghosh A, Hodges JJ, Pilarski PM, Treon SP, Mant MJ, Reiman T, Belch AR, Pilarski LM

Publikováno v: Blood [Blood] 2008 Dec 15; Vol. 112 (13), pp. 5111-21. Date of Electronic Publication: 2008 Sep 24.

Analysis of clonotypic switch junctions reveals multiple myeloma originates from a single class switch event with ongoing mutation in the isotype-switched progeny.

Autor: Taylor BJ; Department of Oncology, University of Alberta and Cross Cancer Institute, Edmonton, Canada., Kriangkum J, Pittman JA, Mant MJ, Reiman T, Belch AR, Pilarski LM

Publikováno v: Blood [Blood] 2008 Sep 01; Vol. 112 (5), pp. 1894-903. Date of Electronic Publication: 2008 Jun 24.

Molecular characterization of Waldenstrom's macroglobulinemia reveals frequent occurrence of two B-cell clones having distinct IgH VDJ sequences.

Autor: Kriangkum J; Departments of Oncology, Cross Cancer Institute and Medicine, University of Alberta, Edmonton, Canada., Taylor BJ, Treon SP, Mant MJ, Reiman T, Belch AR, Pilarski LM

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2007 Apr 01; Vol. 13 (7), pp. 2005-13.