Core binding factor (CBF) is required for Epstein-Barr virus EBNA3 proteins to regulate target gene expression

Autor: Paschos K, Quentin Bazot, Ho G, Ga, Parker, Lees J, Barton G, Mj, Allday

Publikováno v: Europe PubMed Central

ChIP-seq performed on lymphoblastoid cell lines (LCLs), expressing epitope-tagged EBNA3A, EBNA3B or EBNA3C from EBV-recombinants, revealed important principles of EBNA3 binding to chromatin. When combined with global chromatin looping data, EBNA3-bou

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http://hdl.handle.net/10044/1/43151

Requirement for PRC1 subunit BMI1 in host gene activation by Epstein-Barr virus protein EBNA3C.

Autor: Paschos K; Molecular Virology, Department of Medicine, Imperial College London, London W2 1PG, UK., Bazot Q; Molecular Virology, Department of Medicine, Imperial College London, London W2 1PG, UK., Lees J; Oxford Brookes University, Faculty of Health and Life Sciences, Oxford OX3 0BP, Oxfordshire, UK., Farrell PJ; Molecular Virology, Department of Medicine, Imperial College London, London W2 1PG, UK., Allday MJ; Molecular Virology, Department of Medicine, Imperial College London, London W2 1PG, UK.

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Epstein-Barr Virus (EBV) Latent Protein EBNA3A Directly Targets and Silences the STK39 Gene in B Cells Infected by EBV.

Autor: Bazot Q; Molecular Virology, Department of Medicine, Imperial College London, London, United Kingdom q.bazot@imperial.ac.uk., Paschos K; Molecular Virology, Department of Medicine, Imperial College London, London, United Kingdom., Allday MJ; Molecular Virology, Department of Medicine, Imperial College London, London, United Kingdom.

Publikováno v: Journal of virology [J Virol] 2018 Mar 14; Vol. 92 (7). Date of Electronic Publication: 2018 Mar 14 (Print Publication: 2018).

Persistent KSHV Infection Increases EBV-Associated Tumor Formation In Vivo via Enhanced EBV Lytic Gene Expression.

Autor: McHugh D; Viral Immunobiology, Institute of Experimental Immunology, University of Zürich, Zürich, Switzerland., Caduff N; Viral Immunobiology, Institute of Experimental Immunology, University of Zürich, Zürich, Switzerland., Barros MHM; Institute of Pathology, Unfallkrankenhaus Berlin, Berlin, Germany., Rämer PC; Viral Immunobiology, Institute of Experimental Immunology, University of Zürich, Zürich, Switzerland., Raykova A; Viral Immunobiology, Institute of Experimental Immunology, University of Zürich, Zürich, Switzerland., Murer A; Viral Immunobiology, Institute of Experimental Immunology, University of Zürich, Zürich, Switzerland., Landtwing V; Viral Immunobiology, Institute of Experimental Immunology, University of Zürich, Zürich, Switzerland., Quast I; Neuroinflammation, Institute of Experimental Immunology, University of Zürich, Zürich, Switzerland., Styles CT; Section of Virology, Faculty of Medicine, Imperial College London, London, UK., Spohn M; Virus Genomics, Heinrich Pette Institute, Hamburg, Germany., Fowotade A; School of Biosciences and Medicine, University of Surrey, Guildford, UK., Delecluse HJ; DKFZ unit F100/INSERM unit U1074, Heidelberg, Germany., Papoudou-Bai A; Department of Pathology, Faculty of Medicine, University of Ioannina, Ioannina, Greece., Lee YM; Departments of Pathology and Medical Science, Chungnam National University School of Medicine, Daejeon, Korea., Kim JM; Departments of Pathology and Medical Science, Chungnam National University School of Medicine, Daejeon, Korea., Middeldorp J; Department of Pathology, VU University Medical Center and Cancer Center Amsterdam, Amsterdam, the Netherlands., Schulz TF; Institute of Virology, Hannover Medical School, Hannover and German Centre of Infection Research (DZIF), Hannover-Braunschweig Site, Germany., Cesarman E; Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY, USA., Zbinden A; Institute of Medical Virology, University of Zürich, Zürich, Switzerland., Capaul R; Institute of Medical Virology, University of Zürich, Zürich, Switzerland., White RE; Section of Virology, Faculty of Medicine, Imperial College London, London, UK., Allday MJ; Section of Virology, Faculty of Medicine, Imperial College London, London, UK., Niedobitek G; Institute of Pathology, Unfallkrankenhaus Berlin, Berlin, Germany., Blackbourn DJ; School of Biosciences and Medicine, University of Surrey, Guildford, UK., Grundhoff A; Virus Genomics, Heinrich Pette Institute, Hamburg, Germany., Münz C; Viral Immunobiology, Institute of Experimental Immunology, University of Zürich, Zürich, Switzerland. Electronic address: muenzc@immunology.uzh.ch.

Publikováno v: Cell host & microbe [Cell Host Microbe] 2017 Jul 12; Vol. 22 (1), pp. 61-73.e7.

Core binding factor (CBF) is required for Epstein-Barr virus EBNA3 proteins to regulate target gene expression.

Autor: Paschos K; Molecular Virology, Department of Medicine, Imperial College London, Norfolk Place, London, W2 1PG, UK., Bazot Q; Molecular Virology, Department of Medicine, Imperial College London, Norfolk Place, London, W2 1PG, UK., Ho G; Molecular Virology, Department of Medicine, Imperial College London, Norfolk Place, London, W2 1PG, UK., Parker GA; Molecular Virology, Department of Medicine, Imperial College London, Norfolk Place, London, W2 1PG, UK., Lees J; Institute of Structural and Molecular Biology, Division of Biosciences, University College London, Gower Street, London WC1E 6BT, UK., Barton G; Centre for Integrative Systems Biology and Bioinformatics, Imperial College London, London SW7 2AZ, UK., Allday MJ; Molecular Virology, Department of Medicine, Imperial College London, Norfolk Place, London, W2 1PG, UK.

Publikováno v: Nucleic acids research [Nucleic Acids Res] 2017 Mar 17; Vol. 45 (5), pp. 2368-2383.