Zobrazeno 1 - 10
of 341
pro vyhledávání: '"Mizuo, Miyazaki"'
Publikováno v:
Journal of Pharmacological Sciences, Vol 123, Iss 2, Pp 185-194 (2013)
To clarify the matrix metalloproteinase (MMP)-9 inhibitory effect of an angiotensin-converting enzyme (ACE) inhibitor in vivo, we evaluated the effect of an ACE inhibitor against elastase-induced abdominal aortic aneurysm (AAA) progression in mice. M
Externí odkaz:
https://doaj.org/article/3d541fd5c88a4feb8fb8c5eb5af4e43f
Publikováno v:
Journal of Pharmacological Sciences, Vol 118, Iss 3, Pp 311-316 (2012)
Angiotensin II plays an important role in regulating blood pressure. Moreover, angiotensin II directly promotes organ damage by inducing expression of various genes, such as transforming growth factor (TGF)-β and matrix metalloproteinase (MMP)-9 pre
Externí odkaz:
https://doaj.org/article/3e6b9cd686164db2a8d6705d0664dcca
Autor:
Denan Jin, Shinji Takai, Zhonglian Li, Hiroshi Sakonjo, Yoshinori Otsuki, Yuro Shibayama, Mizuo Miyazaki
Publikováno v:
Journal of Pharmacological Sciences, Vol 119, Iss 2, Pp 139-149 (2012)
The neointima formation inside of polytetrafluoroethylene (PTFE) grafts may be associated with the migration of outside fibroblasts to the luminal surfaces. This study aimed to verify whether blockade of fibroblast migration can prevent neointima for
Externí odkaz:
https://doaj.org/article/1b76f6649ee54a12920350de6eb6a69f
Publikováno v:
Journal of Pharmacological Sciences, Vol 116, Iss 3, Pp 309-315 (2011)
Abstract.: Irbesartan, an angiotensin-receptor blocker, is a known agonist of peroxisome proliferator-activated receptor (PPAR) γ. In this study, thirteen-week-old spontaneously hypertensive (SHR)/NDmcr-cp rats, representing a genetic model of metab
Externí odkaz:
https://doaj.org/article/9270a27a3d7f4f1a8365e43c5079082d
Publikováno v:
Journal of Pharmacological Sciences, Vol 113, Iss 4, Pp 301-309 (2010)
Chymase plays a crucial role in angiotensin II formation in various tissues. Angiotensin II induces gene expression of transforming growth factor (TGF)-β and matrix metalloproteinase (MMP)-9 precursors, and chymase can convert precursors of TGF-β a
Externí odkaz:
https://doaj.org/article/9ac2c1566e47442b9c7fcc1f82f3bf75
Publikováno v:
Journal of Pharmacological Sciences, Vol 110, Iss 4, Pp 459-465 (2009)
Abstract.: Angiotensin II may be involved in pancreatic disorganization, but the involvement of chymase has been unclear. In the present study, we examined whether chymase is involved in pancreatic disorganization in hamsters with streptozotocin (STZ
Externí odkaz:
https://doaj.org/article/224b28232c1045efb87c06ea66091493
Autor:
Denan Jin, Shinji Takai, Tetsuya Sugiyama, Tetsuya Hayashi, Masanori Fukumoto, Hidehiro Oku, Yasushi Kitaura, Tsunehiko Ikeda, Mizuo Miyazaki
Publikováno v:
Journal of Pharmacological Sciences, Vol 109, Iss 2, Pp 275-284 (2009)
In the present study, the effects of long-term angiotensin (Ang) II antagonism on the development of cardiac and endothelial disorders were examined in Spontaneously Diabetic Torii (SDT) rats. Blood glucose concentration started to increase markedly
Externí odkaz:
https://doaj.org/article/14c2fbfb12e748beb73c3da2d6d5a52c
Autor:
Mizuo Miyazaki, Shinji Takai
Publikováno v:
Journal of Pharmacological Sciences, Vol 100, Iss 5, Pp 391-397 (2006)
Abstract.: It had been believed that angiotensin II (Ang II) was produced by the renin-angiotensin system (RAS), which was established in the 1950’s. After a while, people realized that the multiple functions of Ang II could not be explained by the
Externí odkaz:
https://doaj.org/article/53f88c93278f45208a411686ec0b2f78
Publikováno v:
Journal of Pharmacological Sciences, Vol 94, Iss 4, Pp 443-448 (2004)
In this study, we evaluated whether a specific chymase inhibitor, TY-51184 (2-[4-(5-fluoro-3-methylbenzo[b]thiophen-2-yl)sulfonamido-3-methanesulfonylphenyl]oxazole-4-carboxylicacid), prevents the vascular proliferation in canine grafted veins. In th
Externí odkaz:
https://doaj.org/article/fe8848f83f664fcbb49502e267f8e776
Autor:
Shinji Takai, Mizuo Miyazaki
Publikováno v:
Hypertension.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c088c4eee6a4a45571714ca46877c55
https://doi.org/10.1161/01.hyp.0000197935.77723.02
https://doi.org/10.1161/01.hyp.0000197935.77723.02