Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Mizuho Sakahara"'
Autor:
Mizuho Sakahara, Takuya Okamoto, Upasna Srivastava, Yasuko Natsume, Hitomi Yamanaka, Yutaka Suzuki, Kazutaka Obama, Satoshi Nagayama, Ryoji Yao
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-12 (2024)
Abstract Tumor tissues consist of heterogeneous cells that originate from stem cells; however, their cell fate determination program remains incompletely understood. Using patient-derived organoids established from patients with advanced colorectal c
Externí odkaz:
https://doaj.org/article/4351b3ab4f974d2fba9b6f53a3b4c902
Autor:
Hiroki Osumi, Atsushi Muroi, Mizuho Sakahara, Hiroshi Kawachi, Takuya Okamoto, Yasuko Natsume, Hitomi Yamanaka, Hiroshi Takano, Daisuke Kusama, Eiji Shinozaki, Akira Ooki, Kensei Yamaguchi, Masashi Ueno, Kengo Takeuchi, Tetsuo Noda, Satoshi Nagayama, Naohiko Koshikawa, Ryoji Yao
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Abstract RAS signaling is a promising target for colorectal cancer (CRC) therapy, and a variety of selective inhibitors have been developed. However, their use has often failed to demonstrate a significant benefit in CRC patients. Here, we used patie
Externí odkaz:
https://doaj.org/article/4a5d7832b5aa4ee2ae61173e8d40b629
Autor:
Daisuke Kusama, Hiroki Osumi, Kengo Takeuchi, Yasuko Natsume, Kensei Yamaguchi, Mizuho Sakahara, Atsushi Muroi, Hiroshi Takano, Ryoji Yao, Satoshi Nagayama, Takuya Okamoto, Naohiko Koshikawa, Akira Ooki, Tetsuo Noda, Hiroshi Kawachi, Eiji Shinozaki, Hitomi Yamanaka, Masashi Ueno
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Scientific Reports
Scientific Reports
RAS signaling is a promising target for colorectal cancer (CRC) therapy, and a variety of selective inhibitors have been developed. However, their use has often failed to demonstrate a significant benefit in CRC patients. Here, we used patient-derive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::984b996d5fd4da5844c9198e0f28139d
https://doaj.org/article/4a5d7832b5aa4ee2ae61173e8d40b629
https://doaj.org/article/4a5d7832b5aa4ee2ae61173e8d40b629
Autor:
Yasuko Natsume, Hiroshi Takano, Masashi Ueno, Jun Oyanagi, Hiroshi Kawachi, Yoshiharu Sakai, Norio Tanaka, Takuya Okamoto, Seiich Mori, Hitomi Yamanaka, Mishio Fusejima, Mizuho Sakahara, Satoshi Nagayama, Daisuke Kusama, Tetsuo Noda, Ryoji Yao
Publikováno v:
Cancer Science
Colorectal cancer (CRC) is caused by genetic alterations, and comprehensive sequence analyses have revealed the mutation landscapes. In addition to somatic changes, genetic variations are considered important factors contributing to tumor development
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6a78b04b61b64e27facc28bd6bea300
https://doi.org/10.1111/cas.13964
https://doi.org/10.1111/cas.13964
Autor:
Ivan de Curtis, Mizuho Sakahara, Hirofumi Sakaguchi, Yuzuru Ninoyu, Takehiko Ueyama, Masaaki Kohta, Yoshitaka Hishikawa, Atsu Aiba, Takashi Nakamura, Eiji Kohmura, Hiroshi Kiyonari, Narantsog Choijookhuu, Yasuo Hisa, Naoaki Saito
Publikováno v:
Development. 144(10):1863-1875
Rac signaling impacts a relatively large number of downstream targets; however, few studies have established an association between Rac pathways and pathological conditions. In the present study, we generated mice with double knockout of Rac1 and Rac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5dcb8ea0c16e8780c1f101bc71a3047
https://hdl.handle.net/20.500.14094/90004351
https://hdl.handle.net/20.500.14094/90004351
Autor:
Mizuho Sakahara, Toshihiko Shiroishi, Ryutaro Kamijo, Shu Takeda, Ayako Kimura, Tsutomu Nohno, Dai Suzuki, Rika Yasuhara, Takanori Amano, Noriyuki Tsumaki, Naoyuki Wada, Atsushi Yamada, Masanori Nakamura, Masaru Tamura, Atsu Aiba
Publikováno v:
Developmental Biology. 335:396-406
Developing vertebrate limbs are often utilized as a model for studying pattern formation and morphogenetic cell death. Herein, we report that conditional deletion of Rac1, a member of the Rho family of proteins, in mouse limb bud mesenchyme led to sk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f17b6be04fb67840ad2d606ee8c0991d
https://doi.org/10.1016/j.ydbio.2009.09.014
https://doi.org/10.1016/j.ydbio.2009.09.014
Publikováno v:
The Kobe journal of medical sciences. 54(6)
To investigate the role of Rac1 for tumorigenesis, we generated inducible transgenic (Tg) mice that simultaneously express polyomavirus middle T antigen (mT) and Cre recombinase under the control of mouse mammary tumor virus long terminal repeat (MMT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::52e775306b7a21693ac7029489caf834
https://pubmed.ncbi.nlm.nih.gov/19628969
https://pubmed.ncbi.nlm.nih.gov/19628969
Autor:
Dai Suzuki, Rika Yasuhara, Takanori Amano, Atsushi Yamada, Ryutaro Kamijo, Masaru Tamura, Shu Takeda, Masanori Nakamura, Atsu Aiba, Noriyuki Tsumaki, Ayako Kimura, Mizuho Sakahara, Toshihiko Shiroishi
Publikováno v:
Transmitters and Modulators in Health and Disease ISBN: 9784431990383
Rac1 is a small GTPase which belongs to the Rho family of proteins, and has multiple roles in cellular function, including actin cytoskeleton organization, transcriptional activation, microtubule formation, and endocytosis. In the present study, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be1ef8940cc46b978c59a218adbc641d
https://doi.org/10.1007/978-4-431-99039-0_14
https://doi.org/10.1007/978-4-431-99039-0_14
Autor:
Kazuki Nakao, Atsu Aiba, Mizuho Sakahara, Masahiro Fukaya, Toshio Terashima, Masahiko Watanabe, Hidetoshi Kassai
Publikováno v:
The European journal of neuroscience. 28(2)
Rac1 is a member of Rho family GTPases and regulates multiple cellular functions through actin cytoskeleton reorganization. During cerebral corticogenesis, Rac1 has been assumed to be involved in neuronal migration, neurite formation, polarization an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dd610f25d9cd3280c7ac8806bd143c8
https://pubmed.ncbi.nlm.nih.gov/18702697
https://pubmed.ncbi.nlm.nih.gov/18702697
Autor:
Takashi Nakamura, Takehiko Ueyama, Yuzuru Ninoyu, Hirofumi Sakaguchi, Narantsog Choijookhuu, Yoshitaka Hishikawa, Hiroshi Kiyonari, Masaaki Kohta, Mizuho Sakahara, de Curtis, Ivan, Eiji Kohmura, Yasuo Hisa, Atsu Aiba, Naoaki Saito
Publikováno v:
Development (09501991); 2017, Vol. 144 Issue 10, p1863-1875, 13p