Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Mizuho Nakayama"'
Autor:
Sho Sugawara, Ryo Okada, Tze Mun Loo, Hisamichi Tanaka, Kenichi Miyata, Masatomo Chiba, Hiroko Kawasaki, Kaoru Katoh, Shizuo Kaji, Yoshiro Maezawa, Koutaro Yokote, Mizuho Nakayama, Masanobu Oshima, Koji Nagao, Chikashi Obuse, Satoshi Nagayama, Keiyo Takubo, Akira Nakanishi, Masato T. Kanemaki, Eiji Hara, Akiko Takahashi
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-13 (2022)
The levels of catalytic subunit of the RNaseH2 enzyme, RNAseH2A, decrease during senescence promoting nucleotide accumulation and a senescence-associated secretory phenotype.
Externí odkaz:
https://doaj.org/article/c3317a7c0604439689709bd59c372b06
Autor:
Takashi Nishina, Yutaka Deguchi, Daisuke Ohshima, Wakami Takeda, Masato Ohtsuka, Shigeyuki Shichino, Satoshi Ueha, Soh Yamazaki, Mika Kawauchi, Eri Nakamura, Chiharu Nishiyama, Yuko Kojima, Satomi Adachi-Akahane, Mizuho Hasegawa, Mizuho Nakayama, Masanobu Oshima, Hideo Yagita, Kazutoshi Shibuya, Tetuo Mikami, Naohiro Inohara, Kouji Matsushima, Norihiro Tada, Hiroyasu Nakano
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
The stromal fibroblast population in the colon is composed of heterogeneous and distinct cell subtypes that play a crucial role in the development of colitis and colon cancer. Here the authors generate IL-11 reporter mice and characterize the origin
Externí odkaz:
https://doaj.org/article/3db3ac661ebb40e88567f28d3824a2f8
Autor:
Sau Yee Kok, Hiroko Oshima, Kei Takahashi, Mizuho Nakayama, Kazuhiro Murakami, Hiroki R. Ueda, Kohei Miyazono, Masanobu Oshima
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Cancer cell clusters metastasize to distant organ by polyclonal manner. Here, the authors show that malignant subclone induces fibrotic niche generation in the liver by hepatic stellate cell activation, supporting survival and colonization of non-met
Externí odkaz:
https://doaj.org/article/b3ef91d200aa418b81c3ad6199d1248d
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Both gain-of-function of mutant p53 (GOF) and loss of wild-type p53 (LOH) are independently associated with cancer. Here, the authors show that LOH promotes GOF tumourigenesis by increasing tumor-initiating ability and metastasis.
Externí odkaz:
https://doaj.org/article/8d1fffa592274a9e92de86ee38fb2d03
Publikováno v:
Cancer Science. 114:1437-1450
Cancer evolution is explained by accumulation of driver mutations and subsequent positive selection by acquired growth advantages like Darwin evolution. However, it has not yet been fully investigated whether negative selection of cells that have los
Autor:
Masanobu Oshima, Seong-Jin Kim, Chan-Young Ock, Chang Pyo Hong, Yutaka Suzuki, Koshi Mimori, Keiichi I. Nakayama, Atsushi Ochiai, Satoshi Fujii, Atsushi Niida, Yuta Kouyama, Hiroko Oshima, Mizuho Nakayama, Eri Sakai
Histological diagnosis of the primary tumors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cea7d7e0d712e8007f5f88a7d8b7398c
https://doi.org/10.1158/0008-5472.22418436
https://doi.org/10.1158/0008-5472.22418436
Autor:
Masanobu Oshima, Seong-Jin Kim, Chan-Young Ock, Chang Pyo Hong, Yutaka Suzuki, Koshi Mimori, Keiichi I. Nakayama, Atsushi Ochiai, Satoshi Fujii, Atsushi Niida, Yuta Kouyama, Hiroko Oshima, Mizuho Nakayama, Eri Sakai
Immune cell infiltration into metastasized liver tumors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45eb7b6f9c16691238f9e5a811b7476b
https://doi.org/10.1158/0008-5472.22418442
https://doi.org/10.1158/0008-5472.22418442
Autor:
Masanobu Oshima, Seong-Jin Kim, Chan-Young Ock, Chang Pyo Hong, Yutaka Suzuki, Koshi Mimori, Keiichi I. Nakayama, Atsushi Ochiai, Satoshi Fujii, Atsushi Niida, Yuta Kouyama, Hiroko Oshima, Mizuho Nakayama, Eri Sakai
Colorectal cancer is driven by the accumulation of driver mutations, but the contributions of specific mutations to different steps in malignant progression are not fully understood. In this study, we generated mouse models harboring different combin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ffc208dc062a369c83a7217f83e0adf
https://doi.org/10.1158/0008-5472.c.6510129.v1
https://doi.org/10.1158/0008-5472.c.6510129.v1
Autor:
Masanobu Oshima, Makoto Mark Taketo, Hiroshi Sato, Toshiro Sato, Kiichiro Tsuchiya, Sylvie Robine, Yusuke Maeda, Xiaoli Ju, Kuniko Naoi, Tae-Su Han, Mizuho Nakayama, Hiroko Oshima
Supplementary Figure S3. Histology of intestines of Tgfbr2ÃŽ?IEC mice.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::609425104251378c180a8a61386740c0
https://doi.org/10.1158/0008-5472.22406670
https://doi.org/10.1158/0008-5472.22406670
Autor:
Masanobu Oshima, Makoto Mark Taketo, Hiroshi Sato, Toshiro Sato, Kiichiro Tsuchiya, Sylvie Robine, Yusuke Maeda, Xiaoli Ju, Kuniko Naoi, Tae-Su Han, Mizuho Nakayama, Hiroko Oshima
Legends for Supplementary Figures S1-S6.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3690fc200b54f4604ad26a6fa5d9aee9
https://doi.org/10.1158/0008-5472.22406679
https://doi.org/10.1158/0008-5472.22406679