Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Mizio Matteucci"'
Autor:
Huiyong Hu, Steven Do, Aleksandr Kolesnikov, Jason Drummond, Jae H. Chang, Jeremy Murray, Heidi J.A. Wallweber, Leanne Ross, Vivienne Allen, Mizio Matteucci, Cameron L. Noland, Justin Ly, Eric Fan, Alastair James Hodges, Andrew Sharpe, Allen J. Ebens, Craig Rouse, Eric Harstad, Joseph P. Lyssikatos, David John Nash, Minghua Sun, Veerendra Munugalavadla, Vickie Tsui, Po-Chang Chiang, Shang-Fan Yu, William Kofie, John Moffat, Wesley Blackaby, Grace Ka Yan Chan, Dionysos Slaga, Wei Jia, Coura Diène, Geoff Del Rosario, Xiaojing Wang
Publikováno v:
Journal of medicinal chemistry. 62(4)
Pim kinases have been targets of interest for a number of therapeutic areas. Evidence of durable single-agent efficacy in human clinical trials validated Pim kinase inhibition as a promising therapeutic approach for multiple myeloma patients. Here, w
Autor:
Nathan J. Brown, Edward McDonald, Jonathan M. Large, Jóhannes Reynisson, Spiros Linardopoulos, Mizio Matteucci, Butrus Atrash, Amir Faisal, Richard Bayliss, Magda Kosmopoulou, Vassilios Bavetsias, Chongbo Sun, Julian Blagg, Nathalie Bouloc
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:5988-5993
Co-crystallisation of the imidazo[1,2-a]pyrazine derivative 15 (3-chloro-N-(4-morpholinophenyl)-6-(pyridin-3-yl)imidazo[1,2-a]pyrazin-8-amine) with Aurora-A provided an insight into the interactions of this class of compound with Aurora kinases. This
Autor:
Spencer Nam, Jae H. Chang, Joseph P. Lyssikatos, Mizio Matteucci, Xiaojing Wang, Minghua Sun, Alastair James Hodges, Suzanne Tay, Connie New, Peter W. Fan, David John Nash, Wesley Blackaby
Publikováno v:
ACS medicinal chemistry letters. 6(8)
Time-dependent inhibition (TDI) of cytochrome P450 (CYP) enzymes may incur serious undesirable drug-drug interactions and in rare cases drug-induced idiosyncratic toxicity. The reactive metabolites are often generated through multiple sequential biot
Publikováno v:
Tetrahedron. 58:9101-9109
Lanthionine is an attractive monomer for the design and synthesis of novel conformationally constrained peptidomimetics, since unlike cystine, the monosulfur bridge of lanthionine is chemically far more robust and also displays a greater degree of co
Autor:
Mizio Matteucci, Ferdinando Pizzo, Oriana Piermatti, Francesco Fringuelli, Maria Cristina Burla
Publikováno v:
The Journal of Organic Chemistry. 66:4661-4666
The [4 + 2] cycloadditions of (E)-2-aryl-1-cyano-1-nitroalkenes 1 with achiral and enantiopure vinyl ethers 2 and 3 carried out in sole water are reported. These reactions occur in a heterogeneous phase under mild conditions and are fast and highly s
Autor:
Mizio Matteucci, Ferdinando Pizzo, Oriana Piermatti, Francesco Fringuelli, Paolino Filippone, Fabio Mantellini, Lucia De Crescentini, Orazio A. Attanasi
Publikováno v:
Helvetica Chimica Acta. 84:513-525
Publikováno v:
Tetrahedron Letters. 45:1399-1401
The total solid phase synthesis of an analogue of the B ring of nisin was achieved, in a biomimetic fashion, via the solid phase diastereoselective cyclisation of a dehydrothiol-containing peptide.
Autor:
Edward McDonald, Florence I. Raynaud, Chongbo Sun, Amir Faisal, Julian Blagg, Paul Workman, Butrus Atrash, Frederique Urban, Richard Bayliss, Gary Box, Jóhannes Reynisson, Vanessa Martins, Suzanne A. Eccles, Mizio Matteucci, Vassilios Bavetsias, Alexis De Haven Brandon, Spiros Linardopoulos, Nathalie Bouloc, Jonathan M. Large, Melanie Valenti, Magda Kosmopoulou, Nicola E. Wilsher
Publikováno v:
Journal of medicinal chemistry. 53(14)
Lead optimization studies using 7 as the starting point led to a new class of imidazo[4,5-b]pyridine-based inhibitors of Aurora kinases that possessed the 1-benzylpiperazinyl motif at the 7-position, and displayed favorable in vitro properties. Cocry
Autor:
Ferdinando Pizzo, Oriana Piermatti, Paolino Filippone, Francesco Fringuelli, Orazio A. Attanasi, Mizio Matteucci, Lucia De Crescentini, Fabio Mantellini
Publikováno v:
ChemInform. 32
Autor:
Ferdinando Pizzo, Oriana Piermatti, Mizio Matteucci, Maria Cristina Burla, Francesco Fringuelli
Publikováno v:
ChemInform. 32
The [4 + 2] cycloadditions of (E)-2-aryl-1-cyano-1-nitroalkenes 1 with achiral and enantiopure vinyl ethers 2 and 3 carried out in sole water are reported. These reactions occur in a heterogeneous phase under mild conditions and are fast and highly s