Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Miyuki Suzawa"'
Publikováno v:
PLoS Biology, Vol 19, Iss 10, p e3001438 (2021)
[This corrects the article DOI: 10.1371/journal.pbio.3000721.].
Externí odkaz:
https://doaj.org/article/e1cad5ee398e4fd6b57fbf018a4479e3
Publikováno v:
PLoS Biology, Vol 18, Iss 5, p e3000721 (2020)
Dietary nutrients provide macromolecules necessary for organism growth and development. In response to animal feeding, evolutionarily conserved growth signaling pathways are activated, leading to increased rates of cell proliferation and tissue growt
Externí odkaz:
https://doaj.org/article/9dbeef7ff36d4f9183cf2ab677ad9726
Autor:
James R. Bayrer, Hongtao Wang, Roy Nattiv, Miyuki Suzawa, Hazel S. Escusa, Robert J. Fletterick, Ophir D. Klein, David D. Moore, Holly A. Ingraham
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Inflammatory bowel disease is characterised by epithelial dysfunction. Here the authors show that loss of the nuclear receptor LRH-1 leads to epithelial disruption by altering Notch signaling in mouse intestinal organoids, and that LRH-1 overexpressi
Externí odkaz:
https://doaj.org/article/90369e6a41a144aa93dc643e36748685
Autor:
Felipe de Jesus Cortez, Miyuki Suzawa, Sam Irvy, John M Bruning, Elena Sablin, Matthew P Jacobson, Robert J Fletterick, Holly A Ingraham, Pamela M England
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0159316 (2016)
Conventional efforts relying on high-throughput physical and virtual screening of large compound libraries have failed to yield high-efficiency chemical probes for many of the 48 human nuclear receptors. Here, we investigated whether disulfide-trappi
Externí odkaz:
https://doaj.org/article/790a70b6099c422699150c6b9744cf8a
Autor:
Miyuki Suzawa, Diego A Miranda, Karmela A Ramos, Kenny K-H Ang, Emily J Faivre, Christopher G Wilson, Laura Caboni, Michelle R Arkin, Yeong-Sang Kim, Robert J Fletterick, Aaron Diaz, John S Schneekloth Jr, Holly A Ingraham
Publikováno v:
eLife, Vol 4 (2015)
SUMO-modification of nuclear proteins has profound effects on gene expression. However, non-toxic chemical tools that modulate sumoylation in cells are lacking. Here, to identify small molecule sumoylation inhibitors we developed a cell-based screen
Externí odkaz:
https://doaj.org/article/7fcdc3aaa9fb4a71988d03b8b7445de9
Publikováno v:
Journal of Pharmacological Sciences, Vol 97, Iss 2, Pp 184-189 (2005)
Peroxisome proliferator-activated receptor gamma (PPARγ) is a ligand-dependent nuclear receptor and regulates adipogenesis and fat metabolism. PPARγ is activated by fatty acid derivatives and some synthetic compounds such as the thiazolidinediones.
Externí odkaz:
https://doaj.org/article/416bae1593704679b79140d6af13ac35
Autor:
Miyuki Suzawa, Holly A Ingraham
Publikováno v:
PLoS ONE, Vol 3, Iss 5, p e2117 (2008)
Atrazine (ATR) remains a widely used broadleaf herbicide in the United States despite the fact that this s-chlorotriazine has been linked to reproductive abnormalities in fish and amphibians. Here, using zebrafish we report that environmentally relev
Externí odkaz:
https://doaj.org/article/d9ebcbd7d8b8438a862f99d377d1613d
Autor:
Miyuki Suzawa, Bland, Michelle L.
Publikováno v:
Development (09501991); Oct2023, Vol. 150 Issue 20, p1-9, 9p
Publikováno v:
Journal of the Endocrine Society. 6:A413-A414
Growth deficits are frequently seen among children in resource-poor settings where malnutrition and chronic enteric infections are common. The insulin/IGF1 signaling pathway promotes cell and organismal growth across the animal kingdom. To better und
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd038de76fc9259d949f2f3753d0895d
https://doi.org/10.1210/jendso/bvac150.861
https://doi.org/10.1210/jendso/bvac150.861
Publikováno v:
PLoS Biology, Vol 18, Iss 5, p e3000721 (2020)
PLoS Biology
PLoS Biology
Dietary nutrients provide macromolecules necessary for organism growth and development. In response to animal feeding, evolutionarily conserved growth signaling pathways are activated, leading to increased rates of cell proliferation and tissue growt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::138c69cefcaf7b86fb1bad8f1acc6261
https://doaj.org/article/9dbeef7ff36d4f9183cf2ab677ad9726
https://doaj.org/article/9dbeef7ff36d4f9183cf2ab677ad9726