Zobrazeno 1 - 2
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pro vyhledávání: '"Miyuki Matsuhashi"'
Publikováno v:
Tetrahedron Letters. 49:6462-6465
Stereoselective synthesis of (−)-centrolobine, an anti-Leishmania agent, was accomplished via an intramolecular Barbier-type reaction of iodo-ester with n- or t-butyllithium followed by Lewis acid-promoted Et3SiH reduction of the resulting hemiacet
Publikováno v:
HETEROCYCLES. 72:151
Intramolecular Barbier reaction of 2-(2-iodoethyl)-3-tetrahydropyranyl esters or acyclic 4-iodobutyl ester with t-BuLi or n-BuLi effected cyclization to give six-membered hemiacetals. Based on the present reaction, the synthesis of 2,6-syn-tetrahydro