Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Miyuki Inoue-Mochita"'
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract In the normal eye, most of the aqueous humor drains through the trabecular meshwork (TM) and Schlemm’s canal (SC). The concentration of transforming growth factor beta 2 (TGF-β2) is increased in the aqueous humor of primary open angle gla
Externí odkaz:
https://doaj.org/article/e59e542976d94b20a080f721735d64f4
Autor:
Tomoyo Matsumura, Tomokazu Fujimoto, Satoshi Iraha, Akiko Futakuchi, Yuji Takihara, Fumika Watanabe-Kitamura, Eri Takahashi, Miyuki Inoue-Mochita, Hidenobu Tanihara, Toshihiro Inoue
Publikováno v:
PLoS ONE, Vol 16, Iss 5, p e0251615 (2021)
[This corrects the article DOI: 10.1371/journal.pone.0242626.].
Externí odkaz:
https://doaj.org/article/fc0f9316d78f42939c22923b9c8ba7ab
TGF-β-induced activation of conjunctival fibroblasts is modulated by FGF-2 and substratum stiffness.
Autor:
Tomoyo Matsumura, Tomokazu Fujimoto, Akiko Futakuchi, Yuji Takihara, Fumika Watanabe-Kitamura, Eri Takahashi, Miyuki Inoue-Mochita, Hidenobu Tanihara, Toshihiro Inoue
Publikováno v:
PLoS ONE, Vol 15, Iss 11, p e0242626 (2020)
PurposeThis study aimed to investigate the effects of substratum stiffness on the sensitivity of human conjunctival fibroblasts to transforming growth factor (TGF)-β, and to explore the molecular mechanism of action.MethodsHuman conjunctival fibrobl
Externí odkaz:
https://doaj.org/article/ad25cd9287174e848b97706fd150b971
Autor:
Tomokazu Fujimoto, Toshihiro Inoue, Saori Ohira, Nanako Awai-Kasaoka, Takanori Kameda, Miyuki Inoue-Mochita, Hidenobu Tanihara
Publikováno v:
Journal of Ophthalmology, Vol 2017 (2017)
Purpose. To investigate the effect of rho kinase inhibitors on oxidative stress in trabecular meshwork (TM) cells. Methods. TM cells were isolated from the eyes of cynomolgus monkeys. Y-27632 and menadione were used to inhibit rho kinase and induce p
Externí odkaz:
https://doaj.org/article/22d1e00d2fcc4844b7df660160743cee
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0161332 (2016)
Anti-vascular endothelial growth factor (VEGF) antibody therapy is an effective treatment for ocular angiogenesis. Although the intraocular pressure of some patients increases after anti-VEGF therapy, the effects of VEGF-A on the aqueous humor outflo
Externí odkaz:
https://doaj.org/article/c4915c8819b6444aac77a3d768ba5d40
Autor:
Miyuki Inoue-Mochita, Toshihiro Inoue, Tomokazu Fujimoto, Takanori Kameda, Nanako Awai-Kasaoka, Naoki Ohtsu, Kenichi Kimoto, Hidenobu Tanihara
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0120774 (2015)
Glaucoma is an age-related neurodegenerative disease of retinal ganglion cells, and appropriate turnover of the extracellular matrix in the trabecular meshwork is important in its pathology. Here, we report the effects of Rho-associated kinase (ROCK)
Externí odkaz:
https://doaj.org/article/98b38f90f60c41f0b067d009828ee6c9
Publikováno v:
Experimental eye research. 223
We investigated the aqueous humor levels of vascular endothelial growth factor (VEGF), soluble VEGF receptor (sVEGFR)1, and sVEGFR2 in glaucoma patients and the correlations among them. Aqueous humor was collected from the anterior chamber at the sta
Autor:
Akiko Futakuchi, Satoshi Iraha, Yuji Takihara, Hidenobu Tanihara, Tomoyo Matsumura, Fumika Watanabe-Kitamura, Eri Takahashi, Miyuki Inoue-Mochita, Toshihiro Inoue, Tomokazu Fujimoto
Publikováno v:
PLoS ONE, Vol 16, Iss 5, p e0251615 (2021)
[This corrects the article DOI: 10.1371/journal.pone.0242626.].
Autor:
Hidenobu Tanihara, Eri Takahashi, Tomokazu Fujimoto, Tomoyo Matsumura, Yuji Takihara, Toshihiro Inoue, Fumika Watanabe-Kitamura, Miyuki Inoue-Mochita, Akiko Futakuchi
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 11, p e0242626 (2020)
PLoS ONE, Vol 15, Iss 11, p e0242626 (2020)
Purpose This study aimed to investigate the effects of substratum stiffness on the sensitivity of human conjunctival fibroblasts to transforming growth factor (TGF)-β, and to explore the molecular mechanism of action. Methods Human conjunctival fibr
Publikováno v:
The Journal of Biological Chemistry
Transforming growth factor-beta 2 (TGF-β2) is highly concentrated in the aqueous humor of primary open-angle glaucoma patients. TGF-β2 causes fibrosis of outflow tissues, such as the trabecular meshwork (TM), and increases intraocular pressure by i