Zobrazeno 1 - 10 of 13 pro vyhledávání: '"Miyuki Fukui"'
2
Synthesis and Evaluation of 1-Arylsulfonyl-3-piperazinone Derivatives as a Factor Xa Inhibitor. II. Substituent Effect on Biological Activities
Autor: Hidemitsu Nishida, Yoshitaka Hosaka, Harada Kousuke, Manabu Itoh, Aki Muraoka, Hidenori Mochizuki, Tomokazu Matsusue, Fumihiko Saitoh, Miwa Matsumoto, Miyuki Fukui, Shuhei Ohnishi, Atsushi Okamoto, Takafumi Mukaihira, Yutaka Miyazaki
Publikováno v: Chemical and Pharmaceutical Bulletin. 50:1187-1194
Intravascular clot formation is an important event in a number of cardiovascular diseases. The prevention of blood coagulation has become a major target for new therapeutic agents. Factor Xa (FXa) is a trypsin-like serine protease that plays a key ro
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9bc367a4c2a5079d0ff7aa49a511ecc
https://doi.org/10.1248/cpb.50.1187
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5
The Effect of Serum Ca2+ Compensation on the Efficacy of Chlorpropamide in Alloxan-diabetic Rabbits
Autor: Kiyoshi Sakai, Toshiaki Nishihata, Noboru Yata, Ayumi Tsutsumi, Miyuki Fukui
Publikováno v: Journal of Pharmacy and Pharmacology. 44:847-850
A decrease in serum Ca2+ concentration was observed in alloxan-diabetic rabbits, with recovery of serum Ca2+ levels achieved following insulin therapy. This suggested that the diabetic condition directly relates to the decrease in serum Ca2+ levels.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::312d36def66f54ad3e180a7d13447cea
https://doi.org/10.1111/j.2042-7158.1992.tb03217.x
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6
Synthesis and evaluation of 1-arylsulfonyl-3-piperazinone derivatives as factor Xa inhibitors IV. A series of new derivatives containing a spiro[5H-oxazolo[3,2-a]pyrazine-2(3H),4'-piperidin]-5-one skeleton
Autor: Hidemitsu Nishida, Hidenori Mochizuki, Miyuki Fukui, Tomokazu Matsusue, Ikuya Shiromizu, Atsushi Okamoto, Fumihiko Saitoh, Harada Kousuke, Yoshitaka Hosaka, Miwa Matsumoto, Takafumi Mukaihira, Shuhei Ohnishi
Publikováno v: Chemicalpharmaceutical bulletin. 52(4)
We have already reported unique compounds containing a N,O-spiro acetal structure as an orally active factor Xa (FXa) inhibitor. This time, we described a N,N-spiro acetal structure as an analogue of the N,O-spiro acetal structure for an orally activ
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::848ce17686456717d7e7ae14dc6ff862
https://pubmed.ncbi.nlm.nih.gov/15056953
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