Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Miyoko Hagiwara"'
Autor:
Michiyuki Kato, Ken Sakurai, Kazuhiro Shimomura, Makoto Shimada, Miyoko Hagiwara, Kazuhisa Furuhama
Publikováno v:
Laboratory animals. 42(2)
Summary Increased incidence of headless sperms (HS) was spontaneously observed in the urine of adolescent naïve male SPF/VAF Crl:CD(SD) rats. To clarify the factors contributing to this event, the HS incidence in urine and the epididymis was periodi
Autor:
Kazuhisa Furuhama, Makoto Shimada, Kazuhiro Shimomura, Michiyuki Kato, Katsuko Fujikawa, Kunio Matsuhashi, Miyoko Hagiwara
Publikováno v:
Reproductive toxicology (Elmsford, N.Y.). 20(4)
The antitumor drug, DE-310, is the slow release form of the camptothecin derivative DX-8951. We investigated a toxicological profile of meningoceles in SD rat fetuses, whose mothers received intravenous DE-310 at several doses, and the time course ch
Autor:
Shigeo Harada, Makoto Shimada, Miyoko Hagiwara, Michiyuki Kato, Kazuhisa Furuhama, Kazuhiro Shimomura
Publikováno v:
Reproductive toxicology (Elmsford, N.Y.). 20(1)
The present study was conducted to clarify the mechanisms of testicular toxicity induced by ethinylestradiol using a rat model maintaining testicular testosterone levels. Twelve-week-old male SD rats were implanted subcutaneously with testosterone (8
Autor:
Michiyuki Kato, Shigeo Harada, Kazuhisa Furuhama, Makoto Shimada, Miyoko Hagiwara, Kazuhiro Shimomura
Publikováno v:
Reproductive toxicology (Elmsford, N.Y.). 18(3)
To investigate mechanisms of the testicular toxicity of nefiracetam and to find sensitive parameters to predict the toxicity, male beagle dogs were orally administered 180 or 300 mg/kg per day of the drug once and for 1 and 4 weeks. Time-course chang