Zobrazeno 1 - 10
of 316
pro vyhledávání: '"Miyoji Hanaoka"'
Autor:
Masami Kawahara, Tomoyuki Ishida, Mariko Asahi, Koichi Yokogawa, Miyoji Hanaoka, Junko Ishizaki, Chie Emoto, Chisato Mukai, Nagao Suzuki, Ken-ichi Miyamoto, Osamu Kataoka, Ryo Matsushita
Publikováno v:
Journal of Pharmacy and Pharmacology. 54:1117-1122
The photodegradation products of the anticancer drug, dacarbazine, cause adverse reactions including local venous pain when injected intravenously. In this study, we attempted to identify which of these products is responsible. We synthesized or purc
Publikováno v:
Tetrahedron. 58:5225-5230
Total synthesis of (±)-ceratopicanol ( 1 ) from commercially available 2-allyl-2-methylcyclopenta-1,3-dione ( 6 ) was completed. By taking advantage of the two carbonyl functionalities, 6 was transformed into the enyne 14 having an alkyne moiety, me
Publikováno v:
Tetrahedron. 58:2755-2762
Treatment of alkyne–Co 2 (CO) 6 complexes possessing a methylidene moiety as well as a terminal hydroxy functionality with SnCl 4 at 0°C effected tandem ring-closure reactions resulting in the formation of 1-oxaspiro[4.4]nonane, 1-oxaspiro[4.5]dec
Publikováno v:
The Journal of Organic Chemistry. 66:5875-5880
The first and stereoselective total syntheses of (-)-ichthyothereol (1) and its acetate ((+)-2) were achieved by incorporation of the two chiral centers of diethyl L-tartrate. The starting diethyl L-tartrate was converted into trans-2-ethynyl-3-hydro
Autor:
Hideo Kato, Yuji Iwanaga, Eiji Takahara, Jun Sakaguchi, Miyoji Hanaoka, Takaharu Saito, Nobuhiko Iwasaki
Publikováno v:
Chemical and Pharmaceutical Bulletin. 49:424-436
Novel benzamide derivatives (19-24, 32a-c, 43d-f), each possessing a cycloaminoalkanecarboxylic acid side chain, were synthesized and their gastrointestinal prokinetic and dopamine D2 receptor antagonist activities were evaluated. 4-[(4-Amino-5-chlor
Autor:
Junko Ishizaki, Tomoyuki Ishida, Fujio Ichimura, Osamu Kataoka, Chisato Mukai, Mariko Asahi, Ryo Matsushita, Miyoji Hanaoka, Ken-ichi Miyamoto, Masami Kawahara, Chie Emoto
Publikováno v:
臨床薬理 = Japanese journal of clinical pharmacology. 32(1):15-22
The anticancer drug, dacarbazine, is known to be photosensitive, and its photode-gradation products have been pointed out as the causes of side effects including local venous pain of injection site. In this study, we attempted to clarify the causativ
Publikováno v:
The Journal of Organic Chemistry. 65:6654-6659
Treatment of (6S,7S)-7-bis(tert-butyldimethylsiloxy)non-1-en-8-ynes with dicobalt octacarbonyl gave the corresponding cobalt complex. This complex was subsequently exposed to the Pauson-Khand conditions in the presence of a promoter such as cyclohexy
Autor:
Miyoji Hanaoka, Eiji Kasamatsu, Yu-ichi Sugimoto, Naoki Miyakoshi, Sumie Yamaguchi, Chisato Mukai
Publikováno v:
The Journal of Organic Chemistry. 65:6761-6765
Publikováno v:
Tetrahedron. 56:2203-2209
Treatment of 2-(3-hydroxy-5-phenylpent-4-yn-1-yl)-2-(trimethylsilylmethyl)tetrahydrofuran (18) with Co2(CO)8 gave the corresponding cobalt complex, which was subsequently exposed to methanesulfonyl chloride and triethylamine in methylene chloride at
Publikováno v:
Chemical and Pharmaceutical Bulletin. 48:399-404
New and convenient synthesis of 2,3,9,10-tetraoxygenated protoberberine alkaloids and their 13-methyl alkaloids through the same intermediates was developed. Acylation of the brominated benzylphenethylamine (13) with alpha-chloro-alpha-(methylthio)ac