Výsledky vyhledávání - "Miyako Masubuchi"

Dereplication of microbial extracts and related analytical technologies

Publikováno v: The Journal of Antibiotics. 67:353-360

Natural products still continue to have an important role as a resource of various biologically active substances. Dereplication is a key process in natural product screening that analyzes the extracts of microbial fermentation broths or plant sample

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::addbc9b0ae9e2de9e34e47acabf9db24
https://doi.org/10.1038/ja.2014.12

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Synthesis and structure–activity relationships of novel benzofuran farnesyltransferase inhibitors

Autor: Yasuhiko Shiratori, Hirosato Ebiike, Takaaki A. Fukami, Masahiro Sakaitani, Toshiyuki Tsukaguchi, Yuko Aoki, Nobuya Ishii, Kohsuke Asoh, Kenichi Kawasaki, Tatsuo Ohtsuka, Miyako Masubuchi, Nobuo Shimma, Osamu Kondoh, Ikumi Hyoudoh, Masami Kohchi

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 19:1753-1757

A series of benzofuran-based farnesyltransferase inhibitors have been designed and synthesized as antitumor agents. Among them, 11f showed the most potent enzyme inhibitory activity (IC 50 = 1.1 nM) and antitumor activity in human cancer xenografts i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05fa59cee8e2a785c9bbfd09094f894f
https://doi.org/10.1016/j.bmcl.2009.01.074

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Synthesis and biological activities of benzofuran antifungal agents targeting fungal N-myristoyltransferase

Autor: Hidetoshi Shindoh, Michiko Hayase, Yuko Aoki, Shinji Tsujii, Hirosato Ebiike, Kenichi Kawasaki, Miyako Masubuchi, Tatsuo Ohtsuka, Yasuhiko Shiratori, Kenji Morikami, Kiyoaki Sakata, Satoshi Sogabe, Nobuo Shimma, Toshihiko Fujii

Publikováno v: Bioorganic & Medicinal Chemistry. 11:4463-4478

The C-4 side chain modification of lead compound 1 has resulted in the identification of a potent and selective Candida albicans N-myristoyltransferase (CaNmt) inhibitor RO-09-4609, which exhibits antifungal activity against C. albicans in vitro. Fur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c318290eaeb164c3c7cec0aa6c5a6d8
https://doi.org/10.1016/s0968-0896(03)00429-2

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Design and synthesis of novel benzofurans as a new class of antifungal agents targeting fungal N-myristoyltransferase. Part 2

Autor: Kenji Morikami, Kenichi Kawasaki, Satoshi Sogabe, Nobuo Shimma, Pingli Liu, Toshihiko Fujii, Yuko Aoki, Miyako Masubuchi, Tatsuo Ohtsuka, Yasuhiko Shiratori, Kiyoaki Sakata, Michiko Hayase, Hirosato Ebiike, Hidetoshi Shindoh

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 12:607-610

Modification of the C-2 position of a benzofuran derivative 6 (RO-09-4609), an N-myristoyltransferase (Nmt) inhibitor, has led us to discover antifungal agents that are active in a murine systemic candidiasis model. The drug design is based on the an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b29f8412cbecee5ee8d45629afa5ed91
https://doi.org/10.1016/s0960-894x(01)00808-3

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Protein-bound conformation of a specific inhibitor againstCandida albicansmyristoyl-CoA:proteinN-myristoyltransferase in the ternary complex withCaNmt and myristoyl-CoA by transferred NOE measurements

Autor: Hans Senn, Kiyoaki Sakata, Miyako Masubuchi, Alfred Ross, Werner Klaus, Takaaki Miura

Publikováno v: European Journal of Biochemistry. 268:4833-4841

Transferred nuclear Overhauser enhancement (trNOE) experiments have been performed to study the bioactive conformation(s) of Ro09-3472/000 derivatives in the ternary complex with Candida albicans myristoyl-CoA: protein N-myristoyltransferase (CaNmt)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6861c2835c4f4706e15d8f4cf6724757
https://doi.org/10.1046/j.1432-1327.2001.02400.x

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Design and synthesis of novel benzofurans as a new class of antifungal agents targeting fungal N -myristoyltransferase. Part 1

Autor: Kiyoaki Sakata, Yoshihiko Ikeda, Nobuo Shimma, Shinji Tsujii, Yasuhiko Shiratori, Toshihiko Fujii, Kenichi Kawasaki, Hirosato Ebiike, Miyako Masubuchi, Tatsuo Ohtsuka, Satoshi Sogabe, Yuko Aoki

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 11:1833-1837

Potent and selective Candida albicans N -myristoyltransferase (CaNmt) inhibitors have been identified through optimization of a lead compound 1 discovered by random screening. The inhibitor design is based on the crystal structure of the CaNmt comple

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8fc148d907ac981661bc0964a7713f3
https://doi.org/10.1016/s0960-894x(01)00319-5

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Cyclothialidine Analogs, Novel DNA Gyrase Inhibitors

Autor: Mikako Fujimori, Junko Watanabe, Miyako Masubuchi, Aya Nishio, Yumiko Nakamura, Fumiko Kawahara, Naoki Nakada, Shoko Matsukuma, Tsutomu Kamiyama, Kayoko Yamaji

Publikováno v: The Journal of Antibiotics. 50:402-411

DNA gyrase inhibitors, cyclothialidines B, C, D and E were isolated from four Streptomycete strains (NR 0659, NR 0660, NR 0661 and NR 0662). Their structures have been elucidated based on the amino acid analysis of the hydrolysates, NMR and HRFAB-MS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4a1c7d048215a6fed0a7c0c94da9b0f
https://doi.org/10.7164/antibiotics.50.402

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Enantioselective synthesis of derivatives and structure-activity relationship study in the development of NA255 as a novel host-targeting anti-HCV agent

Autor: Kohichi Okamato, Miyako Masubuchi, Nobuo Shimma, Fumio Watanabe, Tadakatsu Hayase, Takeshi Murata, Takuo Tsukuda, Masahiro Aoki, Hiroshi Fukuda, Hidetoshi Shindoh, Susumu Komiyama, Kenichi Kawasaki, Masayuki Sudoh, Hiroshi Sakamoto, Kouhei Koyama, Atsunori Ohta, Asao Katsume, Yasuaki Matsubara, Yuko Aoki

Publikováno v: Bioorganicmedicinal chemistry letters. 23(1)

Hepatitis C virus (HCV) infection represents a serious health-care problem. Previously we reported the identification of NA255 from our natural products library using a HCV sub-genomic replicon cell culture system. Herein, we report how the absolute

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a1489dd3166d878060bed6de62087b9
https://pubmed.ncbi.nlm.nih.gov/23164713

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Design and synthesis of novel benzofurans as a new class of antifungal agents targeting fungal N-myristoyltransferase. Part 3

Autor: Kiyoaki Sakata, Kenichi Kawasaki, Michiko Hayase, Hirosato Ebiike, Hidetoshi Shindoh, Tsunehisa Aoyama, Satoshi Sogabe, Kenji Morikami, Nobuo Shimma, Toshihiko Fujii, Yasuhiko Shiratori, Miyako Masubuchi, Tatsuo Ohtsuka, Satoshi Niizuma, Yuko Aoki

Publikováno v: Bioorganicmedicinal chemistry letters. 13(1)

A new series of acid-stable antifungal agents having strong inhibitory activity against Candida albicans N-myristoyltransferase (CaNmt) has been developed starting from acid-unstable benzofuranylmethyl aryl ether 2. The inhibitor design is based on X

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e94c9fd497d860f375d6ad64c2fd84c7
https://pubmed.ncbi.nlm.nih.gov/12467623

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