The impact of CCR8+ regulatory T cells on cytotoxic T cell function in human lung cancer

Autor: Miya Haruna, Azumi Ueyama, Yoko Yamamoto, Michinari Hirata, Kumiko Goto, Hiroshi Yoshida, Naoko Higuchi, Tetsuya Yoshida, Yujiro Kidani, Yamami Nakamura, Morio Nagira, Atsunari Kawashima, Kota Iwahori, Yasushi Shintani, Naganari Ohkura, Hisashi Wada

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)

Abstract Regulatory T cells (Tregs) suppress the host immune response and maintain immune homeostasis. Tregs also promote cancer progression and are involved in resistance to immune checkpoint inhibitor treatments. Recent studies identified selective

Externí odkaz: https://doaj.org/article/51a74d2b5acc4db8a5531e85252d6b2f

The impact of ICOS+ regulatory T cells and Helicobacter pylori infection on the prognosis of patients with gastric and colorectal cancer: potential prognostic benefit of pre-operative eradication therapy

Autor: Miya Haruna, Atsunari Kawashima, Kei Yamamoto, Shinya Urakawa, Tsunekazu Mizushima, Akiko Morimoto-Okazawa, Makoto Yamasaki, Eiichi Sato, Tomoki Makino, Kota Iwahori, Masaki Mori, Yukinori Kurokawa, Yuichiro Doki, Michinari Hirata, Kumiko Goto, Hisashi Wada

Publikováno v: Cancer Immunology, Immunotherapy. 70:443-452

It remains unclear whether Helicobacter pylori (H. pylori), a major cause of gastric cancer (GC), is involved in other intestinal cancers. In our previous study, ICOS+ Foxp3+ CD4+ T cells (ICOS+ Tregs) in GC tumors were identified as effector Tregs a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9975397fb9ba4c6244713bb57fe4de3a
https://doi.org/10.1007/s00262-020-02696-4

CCR8-targeted specific depletion of clonally expanded Treg cells in tumor tissues evokes potent tumor immunity with long-lasting memory

Autor: Yujiro Kidani, Wataru Nogami, Yoshiaki Yasumizu, Atsunari Kawashima, Atsushi Tanaka, Yudai Sonoda, Yumi Tona, Kunitaka Nashiki, Reimi Matsumoto, Masaki Hagiwara, Motonao Osaki, Keiji Dohi, Takayuki Kanazawa, Azumi Ueyama, Mai Yoshikawa, Tetsuya Yoshida, Mitsunobu Matsumoto, Kanji Hojo, Satomi Shinonome, Hiroshi Yoshida, Michinari Hirata, Miya Haruna, Yamami Nakamura, Daisuke Motooka, Daisuke Okuzaki, Yasuko Sugiyama, Makoto Kinoshita, Tatsusada Okuno, Taigo Kato, Koji Hatano, Motohide Uemura, Ryoichi Imamura, Kazunori Yokoi, Atsushi Tanemura, Yasushi Shintani, Tadashi Kimura, Norio Nonomura, Hisashi Wada, Masaki Mori, Yuichiro Doki, Naganari Ohkura, Shimon Sakaguchi

Publikováno v: Proceedings of the National Academy of Sciences. 119

SignificanceImmunosuppressive Foxp3-expressing regulatory T cells (Tregs) in tumor tissues are assumed to be clonally expanding via recognizing tumor-associated antigens. By single-cell RNA sequencing, we have searched for the molecules that are spec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d4710bc2308f5adf752d06c10e3ca4b
https://doi.org/10.1073/pnas.2114282119

The impact of ICOS

Autor: Shinya, Urakawa, Makoto, Yamasaki, Tomoki, Makino, Yukinori, Kurokawa, Kei, Yamamoto, Kumiko, Goto, Miya, Haruna, Michinari, Hirata, Akiko, Morimoto-Okazawa, Atsunari, Kawashima, Kota, Iwahori, Tsunekazu, Mizushima, Eiichi, Sato, Masaki, Mori, Yuichiro, Doki, Hisashi, Wada

Publikováno v: Cancer immunology, immunotherapy : CII. 70(2)

It remains unclear whether Helicobacter pylori (H. pylori), a major cause of gastric cancer (GC), is involved in other intestinal cancers. In our previous study, ICOS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::91dad9e08a7605b505907cb10cd892ee
https://pubmed.ncbi.nlm.nih.gov/32803278

The impact of CCR8+ regulatory T cells on cytotoxic T cell function in human lung cancer.

Autor: Haruna, Miya^1,2 (AUTHOR), Ueyama, Azumi^1,2 (AUTHOR) azumi.ueyama@shionogi.co.jp, Yamamoto, Yoko¹ (AUTHOR), Hirata, Michinari^1,2 (AUTHOR), Goto, Kumiko^1,2 (AUTHOR), Yoshida, Hiroshi² (AUTHOR), Higuchi, Naoko^1,2 (AUTHOR), Yoshida, Tetsuya^2,3 (AUTHOR), Kidani, Yujiro^2,3,4 (AUTHOR), Nakamura, Yamami⁴ (AUTHOR), Nagira, Morio² (AUTHOR), Kawashima, Atsunari^1,5 (AUTHOR), Iwahori, Kota¹ (AUTHOR), Shintani, Yasushi⁶ (AUTHOR), Ohkura, Naganari^3,4 (AUTHOR), Wada, Hisashi¹ (AUTHOR)

Publikováno v: Scientific Reports. 3/30/2022, Vol. 12 Issue 1, p1-12. 12p.