Abundant extrasynaptic expression of α3β4-containing nicotinic acetylcholine receptors in the medial habenula–interpeduncular nucleus pathway in mice

Autor: Asuka Tsuzuki, Miwako Yamasaki, Kohtarou Konno, Taisuke Miyazaki, Norio Takei, Susumu Tomita, Michisuke Yuzaki, Masahiko Watanabe

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-19 (2024)

Abstract Nicotinic acetylcholine receptors (nAChRs) in the medial habenula (MHb)–interpeduncular nucleus (IPN) pathway play critical roles in nicotine-related behaviors. This pathway is particularly enriched in nAChR α3 and β4 subunits, both of w

Externí odkaz: https://doaj.org/article/41a33e14caa64b7481b65fa5e3c29b45

Single-scan volumetric imaging throughout thick tissue specimens by one-touch installable light-needle creating device

Autor: Ching-Pu Chang, Kohei Otomo, Yuichi Kozawa, Hirokazu Ishii, Miwako Yamasaki, Masahiko Watanabe, Shunichi Sato, Ryosuke Enoki, Tomomi Nemoto

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)

Abstract Biological tissues and their networks frequently change dynamically across large volumes. Understanding network operations requires monitoring their activities in three dimensions (3D) with single-cell resolution. Several researchers have pr

Externí odkaz: https://doaj.org/article/3bbd637911584cbb81cd3e0381f50799

All-synchronized picosecond pulses and time-gated detection improve the spatial resolution of two-photon STED microscopy in brain tissue imaging.

Autor: Hirokazu Ishii, Kohei Otomo, Ching-Pu Chang, Miwako Yamasaki, Masahiko Watanabe, Hiroyuki Yokoyama, Tomomi Nemoto

Publikováno v: PLoS ONE, Vol 18, Iss 8, p e0290550 (2023)

Super-resolution in two-photon excitation (2PE) microscopy offers new approaches for visualizing the deep inside the brain functions at the nanoscale. In this study, we developed a novel 2PE stimulated-emission-depletion (STED) microscope with all-sy

Externí odkaz: https://doaj.org/article/b36876af9ad64d128d50d88b3f6e1df9

TMEM163 Regulates ATP-Gated P2X Receptor and Behavior

Autor: Elizabeth J. Salm, Patrick J. Dunn, Lili Shan, Miwako Yamasaki, Nathalie M. Malewicz, Taisuke Miyazaki, Joongkyu Park, Akio Sumioka, R. Richard L. Hamer, Wei-Wu He, Megumi Morimoto-Tomita, Robert H. LaMotte, Susumu Tomita

Publikováno v: Cell Reports, Vol 31, Iss 9, Pp - (2020)

Summary: Fast purinergic signaling is mediated by ATP and ATP-gated ionotropic P2X receptors (P2XRs), and it is implicated in pain-related behaviors. The properties exhibited by P2XRs vary between those expressed in heterologous cells and in vivo. Se

Externí odkaz: https://doaj.org/article/989eda6db00a41328abe0881dd92de9a

Execution of new trajectories toward a stable goal without a functional hippocampus

Autor: Adrian J. Duszkiewicz, Janine I. Rossato, Andrea Moreno, Tomonori Takeuchi, Miwako Yamasaki, Lisa Genzel, Patrick Spooner, Santiago Canals, Richard G. M. Morris

Publikováno v: Duszkiewicz, A J, Rossato, J I, Moreno, A, Takeuchi, T, Yamasaki, M, Genzel, L, Spooner, P, Canals, S & Morris, R G M 2023, ' Execution of new trajectories toward a stable goal without a functional hippocampus ', Hippocampus, vol. 33, no. 6, pp. 769-786 . https://doi.org/10.1002/hipo.23497
Hippocampus, 33, 6, pp. 769-786
Hippocampus, 33, 769-786
Duszkiewicz, A, Rossato, J, Moreno, A, Takeuchi, T, Yamasaki, M, Genzel, L, Spooner, P, Canals, S & Morris, R 2023, ' Execution of new trajectories towards a stable goal without a functional hippocampus ', Hippocampus . https://doi.org/10.1002/hipo.23497

The hippocampus is a critical component of a mammalian spatial navigation system, with the firing sequences of hippocampal place cells during sleep or immobility constituting a “replay” of an animal's past trajectories. A novel spatial navigation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6190679f3c8c2e96308c64f275728aa3
https://pure.au.dk/portal/da/publications/execution-of-new-trajectories-toward-a-stable-goal-without-a-functional-hippocampus(9cc65d14-5467-4aed-9261-aa7339a08482).html