Výsledky vyhledávání - "Miwako Fujisawa"

[Steroid-Resistant Central Nervous System Sarcoidosis: The Selections of Multi-Agent Combination as the Initial Treatment]

Autor: Miwako, Fujisawa, Takashi, Kanda

Publikováno v: Brain and nerve = Shinkei kenkyu no shinpo. 74(5)

Sarcoidosis is a granulomatous multiorgan disease of unknown etiology that commonly affects the respiratory system, eyes, and skin, and less commonly affects the nervous system. Because of its rarity, a standard treatment for central nervous system (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::07af47f4f8bab2e687c05816d50eb470
https://pubmed.ncbi.nlm.nih.gov/35589631

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Spinal cord sarcoidosis in Japan: utility of cerebrospinal fluid examination and nerve conduction study for diagnosis and prognosis prediction

Autor: Miwako Fujisawa, Michiaki Koga, Ryota Sato, Mariko Oishi, Yukio Takeshita, Takashi Kanda

Publikováno v: Journal of neurology. 269(9)

Spinal cord sarcoidosis (SCS) is rare, and its diagnosis is challenging. We examined clinical, laboratory, and imaging features in patients with SCS to obtain useful clues for diagnosis and prognosis. Eleven consecutive patients (four males, seven fe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b98c9a2f20b91b77729e5af573c83f6d
https://pubmed.ncbi.nlm.nih.gov/35430689

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New BBB Model Reveals That IL-6 Blockade Suppressed the BBB Disorder, Preventing Onset of NMOSD

Autor: Miwako Fujisawa, Yasuteru Sano, Joe Nemoto, Susumu Fujikawa, Yukio Takeshita, Shota Miyake, Kenichi Serizawa, Takashi Kanda, Fumitaka Shimizu, Kinya Matsuo, Richard M. Ransohoff, Haruna Tomizawa-Shinohara

Publikováno v: Neurology® Neuroimmunology & Neuroinflammation
article-version (Version of Record) 3

Background and ObjectivesTo evaluate the pathophysiology of neuromyelitis optica spectrum disorder (NMOSD) and the therapeutic mechanism and levels of interleukin-6 (IL-6) blockade (satralizumab), especially with respect to blood-brain barrier (BBB)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cab3d891175f470eb11266b1146a143f
http://europepmc.org/articles/PMC8529420

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IL-6 blockade suppresses the blood-brain barrier disorder, leading to prevention of onset of NMOSD

Autor: Yukio Takeshita, Yasuteru Sano, Takashi Kanda, Haruna Tomizawa-Shinohara, Kinya Matsuo, Miwako Fujisawa, Fumitaka Shimizu, Richard M. Ransohoff, Shota Miyake, Susumu Fujikawa, Kenichi Serizawa, Joe Nemoto

Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune astrocytopathy caused by antibodies against the aquaporin 4(AQP4) in end-feet of astrocytes. Breakdown of the blood–brain barrier (BBB) allowing ingress of AQP4 antibodies into the cen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9750e0897fa27e2fc9ab595fb1191ec8
https://doi.org/10.1101/2021.01.28.428564

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[Spinal Cord Sarcoidosis]

Autor: Miwako, Fujisawa, Michiaki, Koga, Takashi, Kanda

Publikováno v: Brain and nerve = Shinkei kenkyu no shinpo. 72(8)

Spinal cord sarcoidosis is rare, but often appears as a diagnostic challenge in myelopathy of unknown origin. Although definite diagnosis requires histological confirmation of non-caseating epithelioid granuloma in the spinal cord, it is hardly obtai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::669d85a3669624c45b918d48141bcf44
https://pubmed.ncbi.nlm.nih.gov/32741765

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Exploring lipophilic compounds that induce BDNF secretion in astrocytes beyond the BBB using a new multi-cultured human in vitro BBB model

Autor: Miwako Fujisawa, Yukio Takeshita, Susumu Fujikawa, Kinya Matsuo, Masashi Okamoto, Masaya Tamada, Fumitaka Shimizu, Yasuteru Sano, Michiaki Koga, Takashi Kanda

Publikováno v: Journal of Neuroimmunology. 362:577783

Brain-derived neurotrophic factor (BDNF) cannot cross the blood-brain barrier (BBB) when administered peripherally, which hinders its therapeutic potential. We utilized an in vitro BBB model-a tri-culture of a human endothelial cell line, a pericyte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0b7c7c81fc196da131359200b45f1f6
https://doi.org/10.1016/j.jneuroim.2021.577783

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GRP78 Antibodies Are Associated With Blood-Brain Barrier Breakdown in Anti–Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disorder

Autor: Yukio Takeshita, Yasuteru Sano, Takashi Kanda, Ryo Ogawa, Kanako Hara, Ichiro Nakashima, Chihiro Kadono, Yoichi Mizukami, Kazuo Fujihara, Kenji Watanabe, Toshiyuki Takahashi, Tatsuro Misu, Toshihiko Maeda, Fumitaka Shimizu, Miwako Fujisawa

Publikováno v: Neurology® Neuroimmunology & Neuroinflammation
article-version (Version of Record) 3

Background and ObjectivesTo analyze (1) the effect of immunoglobulin G (IgG) from patients with anti–myelin oligodendrocyte glycoprotein antibody (MOG-Ab)–associated disorder on the blood-brain barrier (BBB) endothelial cells and (2) the positivi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e802a6c65aaf8f6c7d6cd76de72b49cc
https://doi.org/10.1212/nxi.0000000000001038

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Charcot-Marie-Tooth disease type 2 caused by homozygous MME gene mutation superimposed by chronic inflammatory demyelinating polyneuropathy

Autor: Michiaki Koga, J. Ogasawara, Hiroshi Takashima, Miwako Fujisawa, Masatoshi Omoto, Takashi Kanda, Yasuteru Sano

Publikováno v: Rinsho Shinkeigaku. 57:515-520

We report a 59-year-old Japanese male who developed gradually worsening weakness and numbness of distal four extremities since age 50. His parents were first cousins, and blood and cerebral spinal examinations were unremarkable. Homozygous mutation o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4fc17ca7cfb72d0e9b8f0d9b74cfe554
https://doi.org/10.5692/clinicalneurol.cn-001036

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Charcot-Marie-Tooth disease type 2 caused by homozygous MME gene mutation superimposed by chronic inflammatory demyelinating polyneuropathy

Autor: Miwako, Fujisawa, Yasuteru, Sano, Masatoshi, Omoto, Jyun-Ichi, Ogasawara, Michiaki, Koga, Hiroshi, Takashima, Takashi, Kanda

Publikováno v: Rinsho shinkeigaku = Clinical neurology. 57(9)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::78fa98827400437ed0d380b1e753978a
https://pubmed.ncbi.nlm.nih.gov/28855494

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