Výsledky vyhledávání - "Miwa Ohtsubo"

Metabolic Fate of Clonidine. (III): Absorption, Distribution and Excretion in Rats after Repeated Subcutaneous Administration of Clonidine

Autor: Katsuyuki Hori, Yasuo Minaki, Yoshitaka Jin, Miwa Ohtsubo, Kazumi Ichige, Yoshio Esumi, Toshiyuki Mashiko, Tohru Yamahata, Atsushi Takao, Hitoshi Nishikawa

Publikováno v: Drug Metabolism and Pharmacokinetics. 11:396-403

After repeated subcutaneous administration of 14C-clonidine to male rats once a day for 21 days at a dose of 1 mg/kg/day, the absorption, distribution and excretion of radioactivity were investigated. 1. No marked variation was observed in the radioa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0007dcb9918a33eebf7b768dafec52b4
https://doi.org/10.2133/dmpk.11.396

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Metabolic Fate of Clonidine. (IV): Plasma Protein Binding of Clonidine In vitro and In vivo and Transfer to Fetus and Milk in Rats after Subcutaneous Administration of Clonidine

Autor: Atsushi Takao, Miwa Ohtsubo, Toshiyuki Mashiko, Yoshio Esumi, Katsuyuki Hori, Yoshitaka Jin, Kumiko Yamashita, Tohru Yamahata, Kazumi Ichige, Yasuo Minaki, Hitoshi Nishikawa

Publikováno v: Drug Metabolism and Pharmacokinetics. 11:404-410

The plasma protein binding of 14C-clonidine in vitro and in vivo and its transfer into the fetus and milk in rats were investigated. 1. The binding ratios of radioactivity in vitro to male rat, dog, monkey and human plasma proteins did not change wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::acd2f31f01f9ad918e9a817bc70eccc4
https://doi.org/10.2133/dmpk.11.404

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Metabolic Fate or Clonidine. (II): Absorption, Distribution and Excretion in Rats and Dogs after Dermal Application of Clonidine Tape, M-5041T

Autor: Yasuo Minaki, Takamasa Kuroya, Yoshitaka Jin, Kazumi Ichige, Yoshio Esumi, Miwa Ohtsubo, Hitoshi Nishikawa, Toshiyuki Mashiko, Katsuyuki Hori, Atsushi Takao, Tohru Yamahata

Publikováno v: Drug Metabolism and Pharmacokinetics. 11:386-395

After application of a transdermal delivery system for 14C-clonidine, 14C-M-5041T, to male rats and a dog for 24 hr, the absorption, distribution and excretion of radioactivity were investigated. 1. In the male rats, applied with a dose of 2.5, 5, 10

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::02e434c152db4d1173e1e8b9b08b2767
https://doi.org/10.2133/dmpk.11.386

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Metabolic Fate of Clonidine. (I): Absorption, Distribution and Excretion in Rats, Dogs and Monkeys after Subcutaneous Administration of Clonidine

Autor: Hitoshi Nishikawa, Kumiko Yamashita, Atsushi Takao, Yoshio Esumi, Katsuyuki Hori, Kazumi Ichige, Tohru Yamahata, Yoshitaka Jin, Yasuo Minaki, Miwa Ohtsubo, Toshiyuki Mashiko

Publikováno v: Drug Metabolism and Pharmacokinetics. 11:375-385

After a single subcutaneous administration of 14C-clonidine at a dose of 1 mg/kg (principally) to rats, dogs and a monkey, the absorption, distribution and excretion of radioactivity were investigated. 1. In the male rats, the radioactivity level in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::170828971202669219f559a3871cc62e
https://doi.org/10.2133/dmpk.11.375

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