Zobrazeno 1 - 10
of 421
pro vyhledávání: '"Miwa MISAWA"'
Publikováno v:
Journal of General and Family Medicine, Vol 24, Iss 3, Pp 190-191 (2023)
Ludwig angina cases that could only be recognized by unmasking.
Externí odkaz:
https://doaj.org/article/3f0c66e5e71749e28c61f3e6cb93c30b
Autor:
Takashi Uzu, Shin-Ichi Araki, Atsunori Kashiwagi, Masakazu Haneda, Daisuke Koya, Hiroki Yokoyama, Yasuo Kida, Motoyoshi Ikebuchi, Takaaki Nakamura, Masataka Nishimura, Noriko Takahara, Toshiyuki Obata, Nobuyuki Omichi, Katsuhiko Sakamoto, Ryosuke Shingu, Hideki Taki, Yoshio Nagai, Hiroaki Tokuda, Munehiro Kitada, Miwa Misawa, Akira Nishiyama, Hiroyuki Kobori, Hiroshi Maegawa, Shiga Committee for Preventing Diabetic Nephropathy
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0164936 (2016)
In patients with diabetes, albuminuria is a risk marker of end-stage renal disease and cardiovascular events. An increased renin-angiotensin system activity has been reported to play an important role in the pathological processes in these conditions
Externí odkaz:
https://doaj.org/article/adf3d8a2d62144fe9e04c3c18113be4e
Publikováno v:
Journal of Pharmacological Sciences, Vol 112, Iss 4, Pp 467-472 (2010)
RhoA upregulation has been suggested in bronchial smooth muscles (BSMs) of asthmatic rats. Here, we cloned/characterized the 5′-promoter region of the rat rhoA. A transcription-initiation site was identified at 66-bp upstream of the reference seque
Externí odkaz:
https://doaj.org/article/ae66e2dd33054107be1d7ae25defd74c
Autor:
Yoshihiko Chiba, Miwa Misawa
Publikováno v:
Journal of Pharmacological Sciences, Vol 114, Iss 3, Pp 264-268 (2010)
Abstract.: MicroRNAs (miRNAs) play important roles in normal and diseased cell functions. The small-GTPase RhoA is one of the key proteins of bronchial smooth muscle (BSM) contraction, and an upregulation of RhoA has been demonstrated in BSMs of expe
Externí odkaz:
https://doaj.org/article/b156873e5d3c40d98aa07762028be2bc
Publikováno v:
Journal of Pharmacological Sciences, Vol 114, Iss 3, Pp 304-310 (2010)
Abstract.: To determine if endogenously generated sphingosine-1-phosphate (S1P) is involved in the development of allergic bronchial asthma, the effects of systemic treatments with SKI-II, a specific inhibitor of sphingosine kinase, on antigen-induce
Externí odkaz:
https://doaj.org/article/e6ae9bc548fb45a787bb061c62ca01a6
Publikováno v:
Journal of Pharmacological Sciences, Vol 112, Iss 1, Pp 83-88 (2010)
Matrix metalloproteinase-12 (MMP-12) has been suggested to play an important role in airway inflammatory diseases. Tumor necrosis factor-α (TNF-α ) is known to cause an upregulation of MMP-12 via an activation of activator protein-1 (AP-1) in monoc
Externí odkaz:
https://doaj.org/article/388056f29a544127b2ba4c67d0b89276
Publikováno v:
Journal of Pharmacological Sciences, Vol 114, Iss 3, Pp 239-247 (2010)
Abstract.: Airway hyperresponsiveness to nonspecific stimuli is one of the characteristic features of allergic bronchial asthma. An elevated contractility of bronchial smooth muscle has been considered as one of the causes of the airway hyperresponsi
Externí odkaz:
https://doaj.org/article/8fb4ecfc55274cb39fa408139e3b57e6
Publikováno v:
Journal of Pharmacological Sciences, Vol 110, Iss 4, Pp 437-444 (2009)
Abstract.: RhoA plays an important role in Ca2+ sensitization of bronchial smooth muscle in antigen-induced airway hyperresponsiveness (AHR). Tumor necrosis factor–α (TNF-α), a major proinflammatory cytokine, is capable of inducing AHR, but the m
Externí odkaz:
https://doaj.org/article/42965c01ff1546ba914822fb377b476a
Publikováno v:
Journal of Pharmacological Sciences, Vol 106, Iss 4, Pp 615-625 (2008)
To determine the mechanism(s) of the inhibitory effect of glucocorticoids on airway hyperresponsiveness in allergic bronchial asthma, the effects of systemic treatment with glucocorticoids on bronchial smooth muscle hyperresponsiveness and RhoA upreg
Externí odkaz:
https://doaj.org/article/7d00282ce7224dc483c883a8c7e3da07
Autor:
Yoshihiko Chiba, Tetsuro Uchida, Hiroyasu Sakai, Teruaki Oku, Saotomo Itoh, Tsutomu Tsuji, Miwa Misawa
Publikováno v:
Journal of Pharmacological Sciences, Vol 95, Iss 4, Pp 479-482 (2004)
By using immunofluorostaining and confocal laser microscopy, acetylcholine-induced translocation of RhoA was visualized in freshly isolated bronchial smooth muscle cells of the rat. The cellular distribution of RhoA at rest was observed uniformly in
Externí odkaz:
https://doaj.org/article/74223c3f54eb46ecbaf6e0047031f76a