Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Miwa Himuro"'
Autor:
Yuka Wakabayashi, Takeshi Miyatsuka, Masaki Miura, Miwa Himuro, Tomomi Taguchi, Hitoshi Iida, Yuya Nishida, Yoshio Fujitani, Hirotaka Watada
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract As diabetes results from the absolute or relative deficiency of insulin secretion from pancreatic β cells, possible methods to efficiently generate surrogate β cells have attracted a lot of efforts. To date, insulin-producing cells have be
Externí odkaz:
https://doaj.org/article/a7987e1429aa46c5a4535e26e4dfe912
Autor:
Masaki Miura, Takeshi Miyatsuka, Takehiro Katahira, Shugo Sasaki, Luka Suzuki, Miwa Himuro, Yuya Nishida, Yoshio Fujitani, Taka-aki Matsuoka, Hirotaka Watada
Publikováno v:
EBioMedicine, Vol 36, Iss , Pp 358-366 (2018)
Background: STAT3 has been demonstrated to play a role in maintaining cellular identities in the pancreas, whereas an activating STAT3 mutation has been linked to impaired β-cell function. Methods: The role of STAT3 in β-cell neogenesis, induced by
Externí odkaz:
https://doaj.org/article/20f5850a175b4d869092d621298cd32c
Autor:
Toshinaru Fukae, Takeshi Miyatsuka, Miwa Himuro, Yuka Wakabayashi, Hitoshi Iida, Shuhei Aoyama, Tomoya Mita, Fuki Ikeda, Hidenori Haruna, Noriyuki Takubo, Yuya Nishida, Toshiaki Shimizu, Hirotaka Watada
Publikováno v:
Biochemical and Biophysical Research Communications. 612:99-104
Autophagy is known to play an essential role in intracellular quality control through the degradation of damaged organelles and components. We previously demonstrated that β-cell-specific autophagy deficient mice, which lack Atg7, exhibited impaired
Autor:
Luka Suzuki, Takeshi Miyatsuka, Miwa Himuro, Yuka Wakabayashi, Sho Osonoi, Masaki Miura, Takehiro Katahira, Yoshio Fujitani, Hitoshi Iida, Hiroki Mizukami, Yuya Nishida, Hirotaka Watada
Publikováno v:
Biochemical and Biophysical Research Communications. 611:38-45
Autophagy is known to play a pivotal role in β-cell function. While the lifelong inhibition of autophagy through Atg7 deletion in β cells has been demonstrated to lead to impaired glucose tolerance together with β-cell dysfunction, the temporal as
Autor:
Shuhei Aoyama, Yuya Nishida, Hirotsugu Uzawa, Miwa Himuro, Akiko Kanai, Kyosei Ueki, Minami Ito, Hitoshi Iida, Isei Tanida, Takeshi Miyatsuka, Yoshio Fujitani, Masaki Matsumoto, Hirotaka Watada
Publikováno v:
Cell Chemical Biology.
Biphasic changes in β-cell mass around parturition are accompanied by increased serotonin production
Autor:
Yoshio Fujitani, Luka Suzuki, Hirotaka Watada, Satoru Takeda, Atsuo Itakura, Masaya Takahashi, Yuya Nishida, Hiroki Mizukami, Takeshi Miyatsuka, Masaki Miura, Yuka Wakabayashi, Miwa Himuro, Takehiro Katahira, Ayako Fukunaka, Sho Osonoi
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports
Scientific Reports
Pancreatic β-cell mass is known to be considerably altered during pregnancy and after parturition in rodents and humans. While β-cell mass increases during pregnancy and starts to return toward its original level after parturition, the cellular mec
Autor:
Ayako Fukunaka, Tamotsu Yoshimori, Hirotaka Watada, Shuhei Aoyama, Yuya Nishida, Takeshi Miyatsuka, Luka Suzuki, Yoshio Fujitani, Miwa Himuro
Publikováno v:
Endocrine Journal. 67:1119-1126
Autophagy has been reported to play a crucial role in the maintenance of intracellular homeostasis, including in pancreatic beta cells. Rubicon, which interacts with the phosphoinositide 3-kinase (PI3K) complex, through autophagy-related 14 (ATG14),
Autor:
Hirotaka Watada, Takehiro Katahira, Luka Suzuki, Miwa Himuro, Hiroaki Satoh, Yuya Nishida, Takeshi Miyatsuka, Masaki Miura
Publikováno v:
Biochemical and Biophysical Research Communications. 521:178-183
The emergence of bihormonal (BH) cells expressing insulin and glucagon has been reported under diabetic conditions in humans and mice. Whereas lineage tracing studies demonstrated that glucagon-producing α cells can be reprogrammed into BH cells, th
Autor:
Shuhei Aoyama, Yuya Nishida, Hirotsugu Uzawa, Miwa Himuro, Akiko Kanai, Kyosei Ueki, Minami Ito, Hitoshi Ida, Isei Tanida, Takeshi Miyatsuka, Yoshio Fujitani, Masaki Matsumoto, Hirotaka Watada
Publikováno v:
SSRN Electronic Journal.
Autor:
Shugo Sasaki, Michelle Y. Y. Lee, Yuka Wakabayashi, Luka Suzuki, Helena Winata, Miwa Himuro, Taka-aki Matsuoka, Iichiro Shimomura, Hirotaka Watada, Francis C. Lynn, Takeshi Miyatsuka
Publikováno v:
Diabetologia. 65(5)
While pancreatic beta cells have been shown to originate from endocrine progenitors in ductal regions, it remains unclear precisely where beta cells emerge from and which transcripts define newborn beta cells. We therefore investigated characteristic