Výsledky vyhledávání - "Mitzli X. Velasco"

Antagonism between the RNA-binding protein Musashi1 and miR-137 and its potential impact on neurogenesis and glioblastoma development

Autor: Mitzli X. Velasco, Allison N. Tegge, Bruna R. Correa, Adam Kosti, Erzsebet Kokovay, Pedro A. F. Galante, Greco Hernández, Luiz O. F. Penalva, Gabriela D A Guardia, Marcia C. Santos, Mei Qiao

Publikováno v: RNA

RNA-binding proteins (RBPs) and miRNAs are critical gene expression regulators that interact with one another in cooperative and antagonistic fashions. We identified Musashi1 (Msi1) and miR-137 as regulators of a molecular switch between self-renewal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d75871226acaa7feece3b367dfdd133
https://doi.org/10.1261/rna.069211.118

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Musashi1 Contribution to Glioblastoma Development via Regulation of a Network of DNA Replication, Cell Cycle and Division Genes

Autor: Michelina Plateroti, Mi Young Son, Mitzli X. Velasco, Talia Delambre, Mirella Baroni, Luiz O. F. Penalva, Patrícia R. Araújo, Xiufen Lei, Mei Qiao, Caihong Yi, Adam Kosti, Paul Hasty, Denise Grieshober, Marco A. R. Ferreira, Saket Choudhary, Suzanne S. Burns

Publikováno v: Cancers, Vol 13, Iss 1494, p 1494 (2021)
Cancers
Cancers, 2021, 13 (7), pp.1494. ⟨10.3390/cancers13071494⟩
Volume 13
Issue 7

Simple Summary Glioblastoma (GBM) is one of the most aggressive tumor types with no effective treatment options. To create new routes for therapy, it is necessary to continue mapping new pathways contributing to gliomagenesis. In this regard, there i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e658f0aa297fb90dc0fc65cb1c6592ba
https://www.mdpi.com/2072-6694/13/7/1494

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Luteolin inhibits Musashi1 binding to RNA and disrupts cancer phenotypes in glioblastoma cells

Autor: Johanna Villarreal, Mei Qiao, Greco Hernández, Caihong Yi, Dmitri N. Ivanov, Mitzli X. Velasco, Luiz O. F. Penalva, Zhonghua Wang, Matthew J. Hart, Yogesh K. Gupta, Christopher G. Hubert, Soni Kaundal, Guiming Li

Publikováno v: RNA Biology. 15:1420-1432

RNA binding proteins have emerged as critical oncogenic factors and potential targets in cancer therapy. In this study, we evaluated Musashi1 (Msi1) targeting as a strategy to treat glioblastoma (GBM); the most aggressive brain tumor type. Msi1 expre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5b15bbc6bd07a5f08cf6b274f78971d
https://doi.org/10.1080/15476286.2018.1539607

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The Diverse Roles of RNA-Binding Proteins in Glioma Development

Autor: Mitzli X, Velasco, Adam, Kosti, Luiz O F, Penalva, Greco, Hernández

Publikováno v: Advances in experimental medicine and biology. 1157

Post-transcriptional regulation of gene expression is fundamental for all forms of life, as it critically contributes to the composition and quantity of a cell's proteome. These processes encompass splicing, polyadenylation, mRNA decay, mRNA editing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::81414dea0009b3adab3056c8f0915d00
https://pubmed.ncbi.nlm.nih.gov/31342436

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On the Origin and Early Evolution of Translation in Eukaryotes

Autor: Mitzli X. Velasco, Greco Hernández, Vincent G. Osnaya, Alejandra García

Publikováno v: Evolution of the Protein Synthesis Machinery and Its Regulation ISBN: 9783319394671

Eukaryotes emerged as a result of profound changes in the global biology of ancestral prokaryotes, being the outcome of large-scale evolutionary innovations at the morphological, metabolic and molecular levels. During these changes, fundamental proce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::42e0ec0464c2470a93a6fbf7c85ab2de
https://doi.org/10.1007/978-3-319-39468-8_5

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