Ebola-GP DNA Prime rAd5-GP Boost: Influence of Prime Frequency and Prime/Boost Time Interval on the Immune Response in Non-human Primates

Autor: Hadar Marcus, Emily Thompson, Yan Zhou, Michael Bailey, Mitzi M. Donaldson, Daphne A. Stanley, Clement Asiedu, Kathryn E. Foulds, Mario Roederer, Juan I. Moliva, Nancy J. Sullivan

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

Heterologous prime-boost immunization regimens are a common strategy for many vaccines. DNA prime rAd5-GP boost immunization has been demonstrated to protect non-human primates against a lethal challenge of Ebola virus, a pathogen that causes fatal h

Externí odkaz: https://doaj.org/article/b4caaee040c843a1b868725d032c92b4

Protection against SARS-CoV-2 Beta Variant in mRNA-1273 Boosted Nonhuman Primates

Autor: Daniel C. Douek, Rachel L. Davis, Alex Van Ry, Timothy S. Johnston, Stephen D. Schmidt, Adrian B. McDermott, John R. Mascola, Yi Zhang, Anne P. Werner, Lilin Lai, Evan Lamb, Sarah O’ Connell, Kevin W. Bock, John-Paul Todd, Misook Choe, Amy R. Henry, Wei Shi, Alan Dodson, Danielle A. Wagner, Matthew A. Koch, Barney S. Graham, Aurélie Ploquin, Mehul S. Suthar, Farida Laboune, Chaim A. Schramm, Mitzi M. Donaldson, Samantha J. Provost, John Misasi, Christopher Stringham, Bianca M. Nagata, Hanne Leth Andersen, Ian N. Moore, Kizzmekia S. Corbett, Andrea Carfi, Robert A. Seder, Sandeep Narpala, Seyhan Boyoglu-Barnum, Mark G. Lewis, Josue Marquez, Sijy O'Dell, Nancy J. Sullivan, Lingshu Wang, Juan I. Moliva, Saule T. Nurmukhambetova, Courtney Tucker, Zackery Flinchbaugh, Laurent Pessaint, Shayne F. Andrew, Mahnaz Minai, Eli Boritz, Barbara J. Flynn, Andrew Pekosz, Dillon R. Flebbe, Daniel Valentin, Darin K. Edwards, Matthew Gagne, Angela Choi, Manjari Sriparna, Kathryn E. Foulds, Martha Nason, Anthony L. Cook, Gabriela S. Alvarado, Kai Wu, Nicole A. Doria-Rose, Mario Roederer

Publikováno v: bioRxiv

Neutralizing antibody responses gradually wane after vaccination with mRNA-1273 against several variants of concern (VOC), and additional boost vaccinations may be required to sustain immunity and protection. Here, we evaluated the immune responses i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab5e0861224a67015c0f073236df6609
https://pubmed.ncbi.nlm.nih.gov/34672695

Vaccine nanodiscs plus polyICLC elicit robust CD8+ T cell responses in mice and non-human primates

Autor: Marisa E. Aikins, Kathryn E. Foulds, Yao Xu, Alireza Hassani Najafabadi, Dan H. Barouch, Emeka B. Okeke, David P. Adams, James J. Moon, Mitzi M. Donaldson, Jutaek Nam, Priyan Weerappuli, Andres M. Salazar, Robert A. Seder, Patrick A Lester, Zeynab Izadi Najaf Abadi, Taryn Hetrick, Wenmin Yuan, Anna Schwendeman

Publikováno v: J Control Release

Conventional cancer vaccines based on soluble vaccines and traditional adjuvants have produced suboptimal therapeutic efficacy in clinical trials. Thus, there is an urgent need for vaccine technologies that can generate potent T cell responses with s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94b4ba39665644bbc81c41368fd176c6
https://europepmc.org/articles/PMC8440392/

Ebola-GP DNA Prime rAd5-GP Boost: Influence of Prime Frequency and Prime/Boost Time Interval on the Immune Response in Non-human Primates

Autor: Yan Zhou, Kathryn E. Foulds, Clement Asiedu, Michael Bailey, Juan I. Moliva, Emily Thompson, Mario Roederer, Daphne A. Stanley, Mitzi M. Donaldson, Nancy J. Sullivan, Hadar Marcus

Publikováno v: Frontiers in Immunology
Frontiers in Immunology, Vol 12 (2021)

Heterologous prime-boost immunization regimens are a common strategy for many vaccines. DNA prime rAd5-GP boost immunization has been demonstrated to protect non-human primates against a lethal challenge of Ebola virus, a pathogen that causes fatal h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b11c4922e8b2bc73fec609af146c26ab
http://europepmc.org/articles/PMC8006325

Evaluation of the mRNA-1273 Vaccine against SARS-CoV-2 in Nonhuman Primates

Autor: Ingelise J. Gordon, Mark G. Lewis, Gabriela S. Alvarado, Ralph S. Baric, Martin R. Gaudinski, Laura Novik, Kwanyee Leung, Jack Greenhouse, Tammy Putman-Taylor, Katelyn Steingrebe, Seyhan Boyoglu-Barnum, Kathryn E. Foulds, Tracey-Ann Campbell, Tongqing Zhou, Wei Shi, I-Ting Teng, Peter D. Kwong, Juan I. Moliva, Laurent Pessaint, Christina Yap, Mahnaz Minai, Olubukola M. Abiona, Nancy J. Sullivan, Nadesh N Nji, Kaitlyn M. Morabito, Amarendra Pegu, Stephen D. Schmidt, Julie E. Ledgerwood, Sunny Himansu, Barbara J. Flynn, Shanai Browne, Anne P. Werner, Darin K. Edwards, Eun Sung Yang, Kevin W. Bock, Joseph R. Francica, Yi Zhang, Dillon R. Flebbe, Kizzmekia S. Corbett, Nicole A. Doria-Rose, Ian N. Moore, Andrea Carfi, Amanda Strasbaugh, Mario Roederer, Guillaume Stewart-Jones, Emily Phung, Robert A. Seder, Tracy J. Ruckwardt, Adrian B. McDermott, Anthony Cook, Sarah O’Connell, Alicia T. Widge, Wing-Pui Kong, Mark K. Louder, Martha Nason, Bob C. Lin, David R. Martinez, Alex Van Ry, Alan Dodson, Evan Lamb, Britta Flach, Bianca M. Nagata, Rebecca J. Loomis, John R. Mascola, Barney S. Graham, John-Paul Todd, Sijy O'Dell, Lauren A. Chang, Naomi Douek, Lingshu Wang, Rebecca A. Gillespie, Hanne Leth Andersen, Amy T. Noe, Mitzi M. Donaldson

Publikováno v: New England Journal of Medicine
The New England Journal of Medicine

Background: Vaccines to prevent coronavirus disease 2019 (Covid-19) are urgently needed. The effect of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines on viral replication in both upper and lower airways is important to evaluate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be1beae7dcc7af2b55333337512c240b