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Specific and safe targeting of glioblastoma using switchable and logic-gated RevCAR T cells

Autor: Abdelfatah Saleh Hassan, H. A., Mitwasi, N., Ullrich, M., Kubeil, M., Toussaint, M., Deuther-Conrad, W., Neuber, C., Arndt, C., Rodrigues Loureiro, L. R., Kegler, A., González Soto, K. E., Belter, B., Rössig, C., Pietzsch, J., Frenz, M., Bachmann, M., Feldmann, A.

Publikováno v: Frontiers in Immunology 14(2023), 1166169

Glioblastoma (GBM) is still an incurable tumor that is associated with high recurrence rate and poor survival despite the current treatment regimes. With the urgent need for novel therapeutic strategies, immunotherapies, especially chimeric antigen r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a7b7e198045e8de2c36b95ca509d5ba
https://doi.org/10.3389/fimmu.2023.1166169

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Akademický článek

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A novel ACE2 decoy for both neutralization of SARS-CoV-2 variants and killing of infected cells

Publikováno v: Frontiers in Immunology 14(2023), 1204543

The COVID-19 pandemic caused by SARS-CoV-2 led to millions of infections and deaths worldwide. As this virus evolves rapidly, there is a high need for treatment options, which can win the race against new emerging variants of concern. Here, we descri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______4577::fdce3d0afa5c96d96efc48a7e94d2f77
https://www.hzdr.de/publications/Publ-37085-1

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Specific Targeting of Fn14-expressing glioblastoma using RevCAR NK-92 cell system

Autor: Abdelfatah Saleh Hassan, H. A., Mitwasi, N., Bachmann, M., Feldmann, A.

Publikováno v: Tumor Immunology meets Oncology (TIMO) XVII 2023 Halle, 20.-22.04.2023, Halle, Germany

Novel immunotherapeutic approaches such as chimeric antigen receptor (CAR)-expressing immune cells are showing promising results against cancer. Among these are the CAR Natural Killer (NK) cells that can be produced from either established cell lines

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______4577::d6fdc8488e3c7661e97f1debd4d4bfe6
https://www.hzdr.de/publications/Publ-36995-1

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Highly Efficient Targeting of EGFR-Expressing Tumor Cells with UniCAR T Cells via Target Modules Based on Cetuximab®

Autor: Jureczek J, Feldmann A, Bergmann R, Arndt C, Berndt N, Koristka S, Loureiro LR, Mitwasi N, Hoffmann A, Kegler A, Bartsch T, Bachmann M

Publikováno v: OncoTargets and Therapy, Vol Volume 13, Pp 5515-5527 (2020)

Justyna Jureczek,1– 3 Anja Feldmann,3 Ralf Bergmann,3,4 Claudia Arndt,3 Nicole Berndt,3 Stefanie Koristka,3 Liliana Rodrigues Loureiro,3,5 Nicola Mitwasi,3 Anja Hoffmann,3 Alexandra Kegler,1– 3 Tabea Bartsch,3 Michael Bachmann1– 3,5,6 1German C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doajarticles::7094288a9c9d989d83513271a9e4559f
https://www.dovepress.com/highly-efficient-targeting-of-egfr-expressing-tumor-cells-with-unicar--peer-reviewed-article-OTT

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As small as it can be: short peptide-derived target molecules for redirection of UniCAR T-cells and imaging of SSTR2-expressing cancers

Autor: Loureiro, L. R., Bergmann, R., Wodtke, R., Brandt, F., Arndt, C., González Soto, K. E., Mitwasi, N., Kegler, A., Bartsch, T., Drewitz, L., Máthé, D., Feldmann, A., Bachmann, M.

Publikováno v: International Conference on Lymphocyte Engineering: ICLE 2022, 31.03.2022, Munich, Germany

Chimeric antigen receptor (CAR) T-cells are undoubtedly a promising approach in cancer immunotherapy. Nevertheless, mild to severe toxicities are associated with this approach including on-target/off-tumor effects and cytokine release syndrome. Aimin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______4577::82ee679d55efbb300cac99b2e78b78d4
https://www.hzdr.de/publications/Publ-33876-1

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Immunotheranostic target modules suitable for imaging and navigation of UniCAR T-cells to strike FAP-expressing solid tumours and their microenvironment

Autor: Loureiro, L. R., Neuber, C., Hoffmann, L., Kubeil, M., Arndt, C., Mitwasi, N., Kegler, A., Bergmann, R., Feldmann, A., Bachmann, M.

Publikováno v: Australian Society of Molecular Imaging (ASMI) Conference 2022, 06.-07.10.2022, Melbourne, Australia

Chimeric antigen receptor (CAR) T-cells are unquestionably considered one of the most promising approaches in cancer immunotherapy. Nonetheless, mild to severe toxicities are associated with this approach which include e.g. on-target/off-tumour toxic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______4577::f2b505dae55a7fe127df79c2a7504987
https://www.hzdr.de/publications/Publ-35718-1

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Adapter CARs: Estimation of the affinity between adapter and CAR domain required for function

Autor: Bartsch, T., Arndt, C., González Soto, K. E., Wodtke, R., Brandt, F., Loureiro, L. R., Mitwasi, N., Kegler, A., Feldmann, A., Bachmann, M.

Publikováno v: TUMOR IMMUNOLOGY MEETS ONCOLOGY (TIMO) XVI 2022 HALLE, 07.-09.07.2022, Halle, Deutschland

As next generation for CAR T cells, adaptor CAR platforms have been developed, which are designed to improve safety, but at the same time maintain the high efficiency of the CAR T cell approach. In our lab, we developed the UniCAR system, which consi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______4577::7de400d0e45c769deb9eb2040bc3f571
https://www.hzdr.de/publications/Publ-35749-1

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