Development of Novel Bacterial Topoisomerase Inhibitors Assisted by Computational Screening.

Autor: Powell JW; Division of Medicinal Chemistry and Pharmacognosy, Department of Chemistry and Biochemistry, Microbial Infection and Immunity, Division of Outcomes and Translational Sciences, Department of Microbiology, and Division of Pharmaceutics and Pharmacology, The Ohio State University, Columbus, Ohio 43210, United States., Mann CA; Division of Medicinal Chemistry and Pharmacognosy, Department of Chemistry and Biochemistry, Microbial Infection and Immunity, Division of Outcomes and Translational Sciences, Department of Microbiology, and Division of Pharmaceutics and Pharmacology, The Ohio State University, Columbus, Ohio 43210, United States., Toth PD; Division of Medicinal Chemistry and Pharmacognosy, Department of Chemistry and Biochemistry, Microbial Infection and Immunity, Division of Outcomes and Translational Sciences, Department of Microbiology, and Division of Pharmaceutics and Pharmacology, The Ohio State University, Columbus, Ohio 43210, United States., Nolan S; Division of Medicinal Chemistry and Pharmacognosy, Department of Chemistry and Biochemistry, Microbial Infection and Immunity, Division of Outcomes and Translational Sciences, Department of Microbiology, and Division of Pharmaceutics and Pharmacology, The Ohio State University, Columbus, Ohio 43210, United States., Steinert A; Division of Medicinal Chemistry and Pharmacognosy, Department of Chemistry and Biochemistry, Microbial Infection and Immunity, Division of Outcomes and Translational Sciences, Department of Microbiology, and Division of Pharmaceutics and Pharmacology, The Ohio State University, Columbus, Ohio 43210, United States., Ove C; Division of Medicinal Chemistry and Pharmacognosy, Department of Chemistry and Biochemistry, Microbial Infection and Immunity, Division of Outcomes and Translational Sciences, Department of Microbiology, and Division of Pharmaceutics and Pharmacology, The Ohio State University, Columbus, Ohio 43210, United States., Seffernick JT; Division of Medicinal Chemistry and Pharmacognosy, Department of Chemistry and Biochemistry, Microbial Infection and Immunity, Division of Outcomes and Translational Sciences, Department of Microbiology, and Division of Pharmaceutics and Pharmacology, The Ohio State University, Columbus, Ohio 43210, United States., Wozniak DJ; Division of Medicinal Chemistry and Pharmacognosy, Department of Chemistry and Biochemistry, Microbial Infection and Immunity, Division of Outcomes and Translational Sciences, Department of Microbiology, and Division of Pharmaceutics and Pharmacology, The Ohio State University, Columbus, Ohio 43210, United States.; Division of Medicinal Chemistry and Pharmacognosy, Department of Chemistry and Biochemistry, Microbial Infection and Immunity, Division of Outcomes and Translational Sciences, Department of Microbiology, and Division of Pharmaceutics and Pharmacology, The Ohio State University, Columbus, Ohio 43210, United States., Kebriaei R; Division of Medicinal Chemistry and Pharmacognosy, Department of Chemistry and Biochemistry, Microbial Infection and Immunity, Division of Outcomes and Translational Sciences, Department of Microbiology, and Division of Pharmaceutics and Pharmacology, The Ohio State University, Columbus, Ohio 43210, United States., Lindert S; Division of Medicinal Chemistry and Pharmacognosy, Department of Chemistry and Biochemistry, Microbial Infection and Immunity, Division of Outcomes and Translational Sciences, Department of Microbiology, and Division of Pharmaceutics and Pharmacology, The Ohio State University, Columbus, Ohio 43210, United States., Osheroff N; Department of Biochemistry and Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States.; Department of Biochemistry and Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States., Yalowich JC; Division of Medicinal Chemistry and Pharmacognosy, Department of Chemistry and Biochemistry, Microbial Infection and Immunity, Division of Outcomes and Translational Sciences, Department of Microbiology, and Division of Pharmaceutics and Pharmacology, The Ohio State University, Columbus, Ohio 43210, United States., Mitton-Fry MJ; Division of Medicinal Chemistry and Pharmacognosy, Department of Chemistry and Biochemistry, Microbial Infection and Immunity, Division of Outcomes and Translational Sciences, Department of Microbiology, and Division of Pharmaceutics and Pharmacology, The Ohio State University, Columbus, Ohio 43210, United States.

Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2024 Jul 15; Vol. 15 (8), pp. 1287-1297. Date of Electronic Publication: 2024 Jul 15 (Print Publication: 2024).

Antibacterial activity of novel bacterial topoisomerase inhibitors against key veterinary pathogens.

Autor: Phelps HA; Global Therapeutics, Anti-Infectives Research, Zoetis, 333 Portage Street, Kalamazoo, MI 49007, United States., Kuhn M; Global Therapeutics, Anti-Infectives Research, Zoetis, 333 Portage Street, Kalamazoo, MI 49007, United States., Lu Y; Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, 500 West 12th Avenue, Columbus, OH 43210, United States., Vibhute S; Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, 500 West 12th Avenue, Columbus, OH 43210, United States., Watts JL; Global Therapeutics, Anti-Infectives Research, Zoetis, 333 Portage Street, Kalamazoo, MI 49007, United States., Mitton-Fry MJ; Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, 500 West 12th Avenue, Columbus, OH 43210, United States. Electronic address: mitton-fry.1@osu.edu.

Publikováno v: Veterinary microbiology [Vet Microbiol] 2023 Sep; Vol. 284, pp. 109840. Date of Electronic Publication: 2023 Jul 29.

Dioxane-Linked Novel Bacterial Topoisomerase Inhibitors Exhibit Bactericidal Activity against Planktonic and Biofilm Staphylococcus aureus In Vitro .

Autor: Chen A; Microbial Infection and Immunity, College of Medicine, The Ohio State University, Columbus, Ohio, USA., Dellos-Nolan S; Microbial Infection and Immunity, College of Medicine, The Ohio State University, Columbus, Ohio, USA., Lu Y; Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, Ohio, USA., West JS; Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, Ohio, USA., Wozniak DJ; Microbial Infection and Immunity, College of Medicine, The Ohio State University, Columbus, Ohio, USA.; Department of Microbiology, College of Arts and Sciences, The Ohio State University, Columbus, Ohio, USA., Mitton-Fry MJ; Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, Ohio, USA.

Publikováno v: Microbiology spectrum [Microbiol Spectr] 2022 Dec 21; Vol. 10 (6), pp. e0205622. Date of Electronic Publication: 2022 Oct 17.

1,3-Dioxane-Linked Novel Bacterial Topoisomerase Inhibitors: Expanding Structural Diversity and the Antibacterial Spectrum.

Autor: Lu Y; Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, Ohio 43210, United States., Mann CA; Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, Ohio 43210, United States., Nolan S; Microbial Infection and Immunity, College of Medicine, The Ohio State University, Columbus, Ohio 43210, United States., Collins JA; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States., Parker E; Department of Veterinary Preventive Medicine, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio 43210, United States., Papa J; Division of Pharmaceutics and Pharmacology, College of Pharmacy, The Ohio State University, Columbus, Ohio 43210, United States., Vibhute S; Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, Ohio 43210, United States., Jahanbakhsh S; Micromyx, Kalamazoo, Michigan 49008, United States., Thwaites M; Micromyx, Kalamazoo, Michigan 49008, United States., Hufnagel D; Micromyx, Kalamazoo, Michigan 49008, United States., Hazbón MH; ATCC, Manassas, Virginia 20110, United States., Moreno J; ATCC, Manassas, Virginia 20110, United States., Stedman TT; ATCC, Manassas, Virginia 20110, United States., Wittum T; Department of Veterinary Preventive Medicine, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio 43210, United States., Wozniak DJ; Microbial Infection and Immunity, College of Medicine, The Ohio State University, Columbus, Ohio 43210, United States.; Department of Microbiology, College of Arts and Sciences, The Ohio State University, Columbus, Ohio 43210, United States., Osheroff N; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States.; Department of Medicine (Hematology/Oncology), Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States.; VA Tennessee Valley Healthcare System, Nashville, Tennessee 37212, United States., Yalowich JC; Division of Pharmaceutics and Pharmacology, College of Pharmacy, The Ohio State University, Columbus, Ohio 43210, United States., Mitton-Fry MJ; Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, Ohio 43210, United States.

Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2022 May 09; Vol. 13 (6), pp. 955-963. Date of Electronic Publication: 2022 May 09 (Print Publication: 2022).

Dioxane-Linked Amide Derivatives as Novel Bacterial Topoisomerase Inhibitors against Gram-Positive Staphylococcus aureus .

Autor: Lu Y; Division of Medicinal Chemistry and Pharmacognosy.Division of Pharmaceutics and Pharmacology, Microbial Infection and Immunity, Department of Chemistry and Biochemistry, and Department of Microbiology, The Ohio State University, Columbus, Ohio 43210, United States., Papa JL; Division of Medicinal Chemistry and Pharmacognosy.Division of Pharmaceutics and Pharmacology, Microbial Infection and Immunity, Department of Chemistry and Biochemistry, and Department of Microbiology, The Ohio State University, Columbus, Ohio 43210, United States., Nolan S; Division of Medicinal Chemistry and Pharmacognosy.Division of Pharmaceutics and Pharmacology, Microbial Infection and Immunity, Department of Chemistry and Biochemistry, and Department of Microbiology, The Ohio State University, Columbus, Ohio 43210, United States., English A; Division of Medicinal Chemistry and Pharmacognosy.Division of Pharmaceutics and Pharmacology, Microbial Infection and Immunity, Department of Chemistry and Biochemistry, and Department of Microbiology, The Ohio State University, Columbus, Ohio 43210, United States., Seffernick JT; Division of Medicinal Chemistry and Pharmacognosy.Division of Pharmaceutics and Pharmacology, Microbial Infection and Immunity, Department of Chemistry and Biochemistry, and Department of Microbiology, The Ohio State University, Columbus, Ohio 43210, United States., Shkolnikov N; Division of Medicinal Chemistry and Pharmacognosy.Division of Pharmaceutics and Pharmacology, Microbial Infection and Immunity, Department of Chemistry and Biochemistry, and Department of Microbiology, The Ohio State University, Columbus, Ohio 43210, United States., Powell J; Division of Medicinal Chemistry and Pharmacognosy.Division of Pharmaceutics and Pharmacology, Microbial Infection and Immunity, Department of Chemistry and Biochemistry, and Department of Microbiology, The Ohio State University, Columbus, Ohio 43210, United States., Lindert S; Division of Medicinal Chemistry and Pharmacognosy.Division of Pharmaceutics and Pharmacology, Microbial Infection and Immunity, Department of Chemistry and Biochemistry, and Department of Microbiology, The Ohio State University, Columbus, Ohio 43210, United States., Wozniak DJ; Division of Medicinal Chemistry and Pharmacognosy.Division of Pharmaceutics and Pharmacology, Microbial Infection and Immunity, Department of Chemistry and Biochemistry, and Department of Microbiology, The Ohio State University, Columbus, Ohio 43210, United States., Yalowich J; Division of Medicinal Chemistry and Pharmacognosy.Division of Pharmaceutics and Pharmacology, Microbial Infection and Immunity, Department of Chemistry and Biochemistry, and Department of Microbiology, The Ohio State University, Columbus, Ohio 43210, United States., Mitton-Fry MJ; Division of Medicinal Chemistry and Pharmacognosy.Division of Pharmaceutics and Pharmacology, Microbial Infection and Immunity, Department of Chemistry and Biochemistry, and Department of Microbiology, The Ohio State University, Columbus, Ohio 43210, United States.

Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2020 Oct 19; Vol. 11 (12), pp. 2446-2454. Date of Electronic Publication: 2020 Oct 19 (Print Publication: 2020).