Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Mitsuyuki Shimada"'
Autor:
Taisuke Tawaraishi, Atsuko Ochida, Yuichiro Akao, Sachiko Itono, Masahiro Kamaura, Thamina Akther, Mitsuyuki Shimada, Stacie Canan, Sanjoy Chowdhury, Yafeng Cao, Kevin Condroski, Ola Engkvist, Amanda Francisco, Sunil Ghosh, Rina Kaki, John M. Kelly, Chiaki Kimura, Thierry Kogej, Kazuya Nagaoka, Akira Naito, Garry Pairaudeau, Constantin Radu, Ieuan Roberts, David Shum, Nao-aki Watanabe, Huanxu Xie, Shuji Yonezawa, Osamu Yoshida, Ryu Yoshida, Charles Mowbray, Benjamin Perry
Publikováno v:
Journal of Medicinal Chemistry. 66:1221-1238
Autor:
Taisuke, Tawaraishi, Atsuko, Ochida, Yuichiro, Akao, Sachiko, Itono, Masahiro, Kamaura, Thamina, Akther, Mitsuyuki, Shimada, Stacie, Canan, Sanjoy, Chowdhury, Yafeng, Cao, Kevin, Condroski, Ola, Engkvist, Amanda, Francisco, Sunil, Ghosh, Rina, Kaki, John M, Kelly, Chiaki, Kimura, Thierry, Kogej, Kazuya, Nagaoka, Akira, Naito, Garry, Pairaudeau, Constantin, Radu, Ieuan, Roberts, David, Shum, Nao-Aki, Watanabe, Huanxu, Xie, Shuji, Yonezawa, Osamu, Yoshida, Ryu, Yoshida, Charles, Mowbray, Benjamin, Perry
Publikováno v:
Journal of medicinal chemistry.
Probing multiple proprietary pharmaceutical libraries in parallel via virtual screening allowed rapid expansion of the structure-activity relationship (SAR) around hit compounds with moderate efficacy against
Autor:
Charles E. Mowbray, Kazuya Nagaoka, Sachiko Itono, Rina Kaki, Yafeng Cao, Hiromi Nakai, Kevin Ronald Condroski, Constantin Radu, Naoaki Watanabe, Garry Pairaudeau, Ieuan Roberts, Benjamin Ian Perry, Ola Engkvist, Yuichiro Akao, Chiaki Kimura, Osamu Yoshida, Ryu Yoshida, Thierry Kogej, Mitsuyuki Shimada, Akira Naito, David Shum, Huanxu Xie, Stacie S. Canan, Shuji Yonezawa
An innovative pre-competitive virtual screening collaboration was engaged to validate and subsequently explore an imidazo[1,2-a]pyridine screening hit for visceral leishmaniasis. In silico probing of five proprietary pharmaceutical company libraries
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2eab07a33951ad2b661f896dbd891f48
https://doi.org/10.26434/chemrxiv.13134785.v1
https://doi.org/10.26434/chemrxiv.13134785.v1
Publikováno v:
Pharmacological Reports. 70:172-177
The effects of farnesoid X receptor (FXR) antagonists on plasma lipid profile in mice have not been investigated thus far. The aim of this study was to investigate the antidyslipidemic effects of an FXR antagonist in dyslipidemic mice, and to clarify
Publikováno v:
European Journal of Pharmacology. 723:108-115
We aimed to elucidate the mechanism underlying the anti-dyslipidemic effect of compound-T3, a farnesoid X receptor antagonist, by investigating its effects on hepatic lipid metabolism in non-human primates. We administered lipid-lowering drugs for 7
Autor:
Mitsuyuki Shimada, Hiroshi Miki, Kouhei Asano, Masaki Ogino, Yoshihisa Nakada, Toshihiro Yamamoto, Hiroshi Yamaguchi, Minori Masago, Norikazu Tamura, Kazuko Aoki, Koki Kato
Publikováno v:
European Journal of Pharmacology. 640:243-249
Coenzyme A (CoA):diacylglycerol acyltransferase 1 (DGAT1) is 1 of the 2 known DGAT enzymes that catalyze the final and only committed step in triacylglycerol synthesis; this enzyme is considered to be a potential therapeutic target in metabolic disor
Autor:
Emiko Shinozawa, Hiroko Yamakawa, Ryuichi Tozawa, Yuichiro Amano, Megumi Haba, Mitsuyuki Shimada
Publikováno v:
Pharmacology Research & Perspectives
We attempted to clarify the therapeutic capability of antagonists of the farnesoid X receptor (FXR), a nuclear receptor that regulates lipid and bile acid metabolism. Herein, we report the antidyslipidemic effects of a novel synthesized FXR antagonis
Autor:
Yoshihisa Nakada, Minori Masago, Mitsuyuki Shimada, Toshihiro Yamamoto, Kouhei Asano, Kazuko Aoki, Hiroshi Miki, Norikazu Tamura, Koki Kato, Masaki Ogino
Publikováno v:
Chemical and Pharmaceutical Bulletin. 58:673-679
In a program to discover new small molecule diacylglycerol acyltransferase (DGAT)-1 inhibitors, screening of our in-house chemical library was carried out using recombinant human DGAT-1 enzyme. From this library, the lead compound 1a was identified a
Autor:
Kevin Bacon, Keiko Fukushima, Koriyama Yuji, Yamauchi Megumi, Nunami Noriko, Mitsuyuki Shimada, Yoshino Takashi, Karl Ziegelbauer, Akihiko Watanabe, Tsutomu Masuda, Hiroki Sato, Toshiki Murata, Timothy B. Lowinger, Kinji Fuchikami, Sachiko Sakakibara, Hiroshi Komura, Takuya Shintani
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:4019-4022
A series of 2-amino-3-cyano-4-alkyl-6-(2-hydroxyphenyl)pyridine derivatives was synthesized and evaluated as I kappaB kinase beta (IKK-beta) inhibitors. Modification of a novel IKK-beta inhibitor 1 (IKK-beta IC(50)=1500 nM, Cell IC(50)=8000 nM) at th
Autor:
Kinji Fuchikami, Sachiko Sakakibara, Tsutomu Masuda, Takuya Shintani, Mitsuyuki Shimada, Karl Ziegelbauer, Yoshino Takashi, Kevin Bacon, Timothy B. Lowinger, Makoto Shimazaki, Toshiki Murata, Hiroshi Kadono
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:4013-4017
A series of 2-amino-3-cyano-4-alkyl-6-(2-hydroxyphenyl)pyridine derivatives was synthesized and evaluated as IkappaB kinase beta (IKK-beta) inhibitors. Substitution of an aminoalkyl group for the aromatic group at the 4-position on the core pyridine