Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Mitsuyoshi Ninomiya"'
Autor:
Helena R. Watts, Hajime Nakamura, Toshiaki Nagafuji, Elaine A. Irving, Rudolf Graf, Andrew R. Lloyd, Andrew K. Dunn, David Virley, Anthony J. Strong, Peter J B Anderson, Mitsuyoshi Ninomiya
Publikováno v:
Brain. 130:995-1008
In the light of accumulating evidence for the occurrence of spontaneous cortical spreading depression and peri-infarct depolarizations in the human brain injured by trauma or aneurysmal subarachnoid haemorrhage, we used DC electrode recording and las
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73285b94e3b013f3d369b124c62eb680
https://doi.org/10.1093/brain/awl392
https://doi.org/10.1093/brain/awl392
Autor:
Yoko Hayasaki-Kajiwara, Mitsuyoshi Ninomiya, Toshitake Shimamura, Takanori Iwasaki, Masatoshi Nakajima, Shin-ichi Mihara, Masafumi Fujimoto, Noriyuki Naya, Masao Masui, Masaru Kawakami
Publikováno v:
Journal of Cardiovascular Pharmacology. 37:471-482
The pharmacologic properties of a novel nonpeptide endothelin (ET) receptor antagonist, S-1255 ([R]-[+]-2-[benzo(1,3)dioxol-5-yl]-6-isopropyl-4-[4-methoxyphenyl]-2H-chromene-3-carboxylic acid), was studied. [3H]S-1255 specifically bound to porcine ao
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e99b18d0ae7f35b76c7e845732fd41f
https://doi.org/10.1097/00005344-200104000-00014
https://doi.org/10.1097/00005344-200104000-00014
Autor:
Kazuyuki Minagawa, Mitsuyoshi Ninomiya, Kenji Asakura, Tatsuro Yagami, Kiyomi Kagawa, Toshiyuki Kanemasa, Masatoshi Nakajima
Publikováno v:
Brain Research. 873:94-101
In this study, we investigated the effect of alpha-eudesmol, which potently inhibits the presynaptic omega-agatoxin IVA-sensitive (P/Q-type) Ca(2+) channel, on neurogenic inflammation following electrical stimulation of rat trigeminal ganglion. Treat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e38474b6abd5a961a76c1825aa420a9
https://doi.org/10.1016/s0006-8993(00)02527-0
https://doi.org/10.1016/s0006-8993(00)02527-0
Autor:
Tsuyoshi Kihara, Mitsuyoshi Ninomiya, Toshiyuki Kanemasa, Yoshitaka Araki, Yoshiyuki Matsuo, Kazuyuki Minagawa, Kenji Asakura, Takeo Oshima, Kiyomi Kagawa
Publikováno v:
European Journal of Pharmacology. 394:57-65
omega-Agatoxin IVA-sensitive Ca(2+) channels have been thought to be involved in physiological excitatory amino acid glutamate release and these channels may also contribute to the development of ischemic brain injury. Recently, we demonstrated that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37f6ff795c47c20f771cb41d40b43425
https://doi.org/10.1016/s0014-2999(00)00102-3
https://doi.org/10.1016/s0014-2999(00)00102-3
Publikováno v:
Drug Development Research. 48:160-170
The protective effects of the Na + /H + exchange inhibitors amiloride, EIPA (5-(N-ethyl-N-sopropyl)-amiloride), and HOE 694 (3-methylsulfonyl-4-(1-piperidino) benzoyl-guanidine) and the Na + / Ca 2+ exchange inhibitor, DCB (3,4-Dichlorobenzamil) on i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7fa0d7721a827a90eca4b5e1058a1b0f
https://doi.org/10.1002/(sici)1098-2299(199912)48:4<160::aid-ddr3>3.0.co
https://doi.org/10.1002/(sici)1098-2299(199912)48:4<160::aid-ddr3>3.0.co
Publikováno v:
Brain Research. 823:169-176
Recently, the omega-agatoxin IVA (omega-Aga-IVA)-sensitive Ca2+ channel has been demonstrated to play an important role in the physiological neurotransmitter release in mammalian nerve terminals. In this study, we demonstrate that alpha-eudesmol from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b012ece18d4d675f816460598e3e911b
https://doi.org/10.1016/s0006-8993(99)01165-8
https://doi.org/10.1016/s0006-8993(99)01165-8
Autor:
Mitsuyoshi Ninomiya, Toshitake Shimamura, Noriyuki Naya, Mitsuru Notoya, Yoko Hayasaki-Kajiwara, Takanori Iwasaki, Masatoshi Nakajima
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 276:H383-H390
Vascular response mediating endothelin (ET)Breceptor was studied using isolated rabbit mesenteric arteries. ET-1 (0.1–30 nM) caused a concentration-dependent contraction, whereas ET-3 >100 nM caused only weak contraction. Up to 1 μM of sarafotoxin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b7e1be90bda76f42267379d920582b9
https://doi.org/10.1152/ajpheart.1999.276.2.h383
https://doi.org/10.1152/ajpheart.1999.276.2.h383
Autor:
Kyuya Kogure, Hiroshi Onodera, Yoshiyuki Matsuo, Tsuyoshi Kihara, Mitsuyoshi Ninomiya, Masato Ikeda
Publikováno v:
Brain Research. 709:296-302
Oxygen radicals produced by activated neutrophils have been involved in brain injury during ischemia-reperfusion. Platelet-activating factor (PAF) is a candidate as one of the mediators of neutrophil activation during cerebral ischemia-reperfusion. R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29c27014ba3f63b5eefc2d99efc47a88
https://doi.org/10.1016/0006-8993(95)01324-5
https://doi.org/10.1016/0006-8993(95)01324-5
Autor:
Yoshiyuki Matsuo, Masato Ikeda, Kyuya Kogure, Mitsuyoshi Ninomiya, Hiroshi Onodera, Tsuyoshi Kihara
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 15:941-947
A growing body of experimental data indicate that oxygen radicals may mediate the brain injury during ischemia–reperfusion. One potential source of oxygen radicals is activated neutrophils. To study the role of neutrophils in radical production dur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77df1a493addbebb9872822876c4bddb
https://doi.org/10.1038/jcbfm.1995.119
https://doi.org/10.1038/jcbfm.1995.119
Autor:
Alissa Kapke, Michael Chopp, Bruce Albala, Cindi Roberts, Rui Lan Zhang, Chunling Zhang, Mei Lu, Li Zhang, Zheng Gang Zhang, Yisheng Cui, Mitsuyoshi Ninomiya, Toshiaki Nagafuji
Publikováno v:
Stroke. 39(10)
Background and Purpose— Using a model of embolic stroke, the present study tested the hypothesis that blockage of endothelin-1 with S-0139, a specific endothelin type A receptor (ET A ) antagonist, enhances the neuroprotective effect of recombinant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29758628d30b100299d3dd4074b49115
https://pubmed.ncbi.nlm.nih.gov/18669895
https://pubmed.ncbi.nlm.nih.gov/18669895