Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Mitsuyasu Tabo"'
Autor:
Yoshiyuki Arata, Shigeki Motoyama, Mariko Yano, Tatsuya Ikuno, Shunsuke Ito, Tomochika Matsushita, Akira Takeiri, Yukari Nishito, Nami Yabuki, Hideaki Mizuno, Zenjiro Sampei, Masayuki Mishima, Masaki Honda, Jumpei Kiyokawa, Hiromi Suzuki, Shuichi Chiba, Mitsuyasu Tabo, Chiyomi Kubo
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTTherapeutic antibodies sometimes elicit anti-drug antibodies (ADAs) that can affect efficacy and safety. Engineered antibodies that contain artificial amino acid sequences are potentially highly immunogenic, but this is currently difficult to
Externí odkaz:
https://doaj.org/article/9c8b83e3cca74382a102aa8a0b0f06ad
Autor:
Chisato Kaneko, Haruka Tsutsui, Kazuhisa Ozeki, Masaki Honda, Kenta Haraya, Yoshinori Narita, Mika Kamata-Sakurai, Junichi Kikuta, Mitsuyasu Tabo, Masaru Ishii
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-8 (2022)
Abstract STA551, a novel anti-CD137 switch antibody, binds to CD137 in an extracellular ATP concentration-dependent manner. Although STA551 is assumed to show higher target binding in tumor tissues than in normal tissues, quantitative detection of th
Externí odkaz:
https://doaj.org/article/c4d3885a5dc747a18ef3d9f7eaccf9fa
Autor:
Shunsuke Ito, Tatsuya Ikuno, Masayuki Mishima, Mariko Yano, Toshiko Hara, Taichi Kuramochi, Zenjiro Sampei, Tetsuya Wakabayashi, Mitsuyasu Tabo, Shuichi Chiba, Chiyomi Kubo
Publikováno v:
Journal of Immunotoxicology, Vol 16, Iss 1, Pp 125-132 (2019)
Monoclonal antibody (mAb) drugs offer a number of valuable treatments. Many newly developed mAb drugs include artificial modification of amino acid sequences from human origin, which may cause higher immunogenicity to induce anti-drug antibodies (ADA
Externí odkaz:
https://doaj.org/article/865b1a01b0cb44aba41b7a5a0489c967
Publikováno v:
Journal of Pharmacological Sciences, Vol 121, Iss 2, Pp 131-137 (2013)
Our previous study has shown that the corrected QT (QTc) interval of the electrocardiogram is longer during the dark period than during the light period in telemetered common marmosets. In the present study, we investigated the involvement of sympath
Externí odkaz:
https://doaj.org/article/7e99c774bc8b486182595cdc7824e726
Publikováno v:
Journal of Pharmacological Sciences, Vol 117, Iss 3, Pp 149-159 (2011)
Abstract.: Cardiomyocytes derived from human induced pluripotent stem cells (hiPS-CMs) hold great promise for development of in vitro research tools to assess cardiotoxicity, including QT prolongation. In the present study, we aimed to clarify the el
Externí odkaz:
https://doaj.org/article/c75c765845c645649aa2e17814bd0878
Autor:
Seiji Hayashi, Yoshihide Kii, Mitsuyasu Tabo, Hitoshi Fukuda, Tetsuji Itoh, Takashi Shimosato, Hideto Amano, Mamoru Saito, Hajime Morimoto, Kiyoshi Yamada, Atsuhiro Kanda, Toshimasa Ishitsuka, Takanobu Yamazaki, Yoichi Kiuchi, Shinya Taniguchi, Tatsuya Mori, Shigekazu Shimizu, Yuji Tsurubuchi, Shun-ichi Yasuda, Shin-ichi Kitani, Chiaki Shimada, Kazuo Kobayashi, Masaharu Komeno, Chieko Kasai, Toshiyasu Hombo, Keiji Yamamoto
Publikováno v:
Journal of Pharmacological Sciences, Vol 99, Iss 5, Pp 423-437 (2005)
To construct a non-clinical database for drug-induced QT interval prolongation, the electrophysiological effects of 11 positive and 10 negative compounds on action potentials (AP) in guinea-pig papillary muscles were investigated in a multi-site stud
Externí odkaz:
https://doaj.org/article/a0418258c79346d3ac043532653edbdc
Autor:
Yoshihide Kii, Seiji Hayashi, Mitsuyasu Tabo, Takashi Shimosato, Hitoshi Fukuda, Tetsuji Itoh, Hideto Amano, Mamoru Saito, Hajime Morimoto, Kiyoshi Yamada, Atsuhiro Kanda, Toshimasa Ishitsuka, Takanobu Yamazaki, Yoichi Kiuchi, Shinya Taniguchi, Tatsuya Mori, Shigekazu Shimizu, Yuji Tsurubuchi, Shun-ichi Yasuda, Shin-ichi Kitani, Chiaki Shimada, Kazuo Kobayashi, Masaharu Komeno, Chieko Kasai, Toshiyasu Hombo, Keiji Yamamoto
Publikováno v:
Journal of Pharmacological Sciences, Vol 99, Iss 5, Pp 449-457 (2005)
Certain compounds that prolong QT interval in humans have little or no effect on action-potential (AP) duration used traditionally, but they inhibit rapidly-activated-delayed-rectifier potassium currents (IKr) and/or human ether-a-go-go-related gene
Externí odkaz:
https://doaj.org/article/607f605ce3e84d8090d1635dfe43b73c
Autor:
Chisato Kaneko, Haruka Tsutsui, Kazuhisa Ozeki, Masaki Honda, Kenta Haraya, Yoshinori Narita, Mika Kamata-Sakurai, Junichi Kikuta, Mitsuyasu Tabo, Masaru Ishii
STA551, a novel anti-CD137 switch antibody, binds to CD137 in an extracellular ATP (exATP) concentration dependent manner. Although STA551 was assumed to show higher target binding in tumor than normal tissues, quantitative detection of the target bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c42874c8699ef32676a4e1849f880e7
https://doi.org/10.21203/rs.3.rs-1126148/v1
https://doi.org/10.21203/rs.3.rs-1126148/v1
Autor:
Chisato Kaneko, Haruka Tsutsui, Kazuhisa Ozeki, Masaki Honda, Kenta Haraya, Yoshinori Narita, Mika Kamata-Sakurai, Junichi Kikuta, Mitsuyasu Tabo, Masaru Ishii
Publikováno v:
Scientific reports. 12(1)
STA551, a novel anti-CD137 switch antibody, binds to CD137 in an extracellular ATP concentration-dependent manner. Although STA551 is assumed to show higher target binding in tumor tissues than in normal tissues, quantitative detection of the target
Autor:
Chiyomi Kubo, Taichi Kuramochi, Shuichi Chiba, Masayuki Mishima, Tetsuya Wakabayashi, Mitsuyasu Tabo, Toshiko Hara, Shunsuke Ito, Tatsuya Ikuno, Zenjiro Sampei, Mariko Yano
Publikováno v:
Journal of Immunotoxicology, Vol 16, Iss 1, Pp 125-132 (2019)
Monoclonal antibody (mAb) drugs offer a number of valuable treatments. Many newly developed mAb drugs include artificial modification of amino acid sequences from human origin, which may cause higher immunogenicity to induce anti-drug antibodies (ADA