Zobrazeno 1 - 10
of 182
pro vyhledávání: '"Mitsuteru, Numazawa"'
Autor:
Akira Honda, Kouwa Yamashita, Tadashi Ikegami, Takashi Hara, Teruo Miyazaki, Takeshi Hirayama, Mitsuteru Numazawa, Yasushi Matsuzaki
Publikováno v:
Journal of Lipid Research, Vol 50, Iss 10, Pp 2124-2130 (2009)
We describe a new sensitive and specific method for the quantification of serum malonate (malonic acid, MA), which could be a new biomarker for de novo lipogenesis (fatty acid synthesis). This method is based upon a stable isotope-dilution technique
Externí odkaz:
https://doaj.org/article/bbf7db6f12164a6cb7893e70e5f2c913
Highly sensitive quantification of key regulatory oxysterols in biological samples by LC-ESI-MS/MSs⃞
Autor:
Akira Honda, Kouwa Yamashita, Takashi Hara, Tadashi Ikegami, Teruo Miyazaki, Mutsumi Shirai, Guorong Xu, Mitsuteru Numazawa, Yasushi Matsuzaki
Publikováno v:
Journal of Lipid Research, Vol 50, Iss 2, Pp 350-357 (2009)
We describe a highly sensitive and specific method for the quantification of key regulatory oxysterols in biological samples. This method is based upon a stable isotope dilution technique by liquid chromatography-tandem mass spectrometry (LC-MS/MS).
Externí odkaz:
https://doaj.org/article/b533eac0b8c547cf95a84cfe8f5953d8
Autor:
Akira Honda, Kouwa Yamashita, Hiroshi Miyazaki, Mutsumi Shirai, Tadashi Ikegami, Guorong Xu, Mitsuteru Numazawa, Takashi Hara, Yasushi Matsuzaki
Publikováno v:
Journal of Lipid Research, Vol 49, Iss 9, Pp 2063-2073 (2008)
We have developed a highly sensitive and specific method for the analysis of serum sterol profiles. Sterols in 1 μl of dried serum were derivatized into picolinyl esters (3β-picolinate) and analyzed by liquid chromatography-tandem mass spectrometry
Externí odkaz:
https://doaj.org/article/925432fa8cde4b56ba3be4f41bf5d721
Autor:
Akira Honda, Kouwa Yamashita, Mitsuteru Numazawa, Tadashi Ikegami, Mikio Doy, Yasushi Matsuzaki, Hiroshi Miyazaki
Publikováno v:
Journal of Lipid Research, Vol 48, Iss 2, Pp 458-464 (2007)
We describe a highly sensitive and specific method for the quantification of serum 7α-hydroxy-4-cholesten-3-one (C4), which has been used as a biomarker for bile acid biosynthesis. This method is based upon a stable isotope dilution technique by liq
Externí odkaz:
https://doaj.org/article/81ea88173055440883cd2edc253c91ce
Autor:
J. Yamaki, Hiroji Okada, Chiaki Sakai, Hideo Honjo, Kazuo Otsubo, Toshio Nambara, Masahiro Fujii, Mitsuteru Numazawa, Jinsuke Yasuda, Takao Yamamoto, Katsumi Tsukamoto, Kenji Omori
Publikováno v:
Asia-Oceania Journal of Obstetrics and Gynaecology. 7:341-348
Estriol-16α-glucosiduronate in the urine and serum of pregnant women was measured by a direct radioimmunoassay which was highly specific for this compound and did not require hydrolysis or chromatography. Urinary and serum estriol-16α-glucosidurona
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95ffd1a51c2a8a484d87591594090870
https://doi.org/10.1111/j.1447-0756.1981.tb00540.x
https://doi.org/10.1111/j.1447-0756.1981.tb00540.x
Publikováno v:
Steroids. 75:330-337
A series of 2-phenylaliphatic-substituted androsta-1,4-diene-3,17-diones (6) as well as their androstenedione derivatives (5) were synthesized as aromatase inhibitors to gain insights of structure–activity relationships of varying the alkyl moiety
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d66180b19776341ace1951c2296cc27f
https://doi.org/10.1016/j.steroids.2010.01.008
https://doi.org/10.1016/j.steroids.2010.01.008
Autor:
Mitsunobu Okuyama, Kouwa Yamashita, Madoka Takahashi, Yoshimichi Miyashiro, Hitoe Maekubo, Mitsuteru Numazawa, Seijiro Honma
Publikováno v:
Steroids. 74:920-926
We developed highly sensitive detection of testosterone (T) and 5α-dihydrotestosterone (DHT) by liquid chromatography–electrospray ionization tandem mass spectrometry using high proton affinitive derivatization of 17β-hydroxyl group of T and DHT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6c5d9dd9e0c66c99fa58e456511fdb4
https://doi.org/10.1016/j.steroids.2009.06.007
https://doi.org/10.1016/j.steroids.2009.06.007
Publikováno v:
Steroids. 74:884-889
Inhibition of aromatase is an efficient approach for the prevention and treatment of breast cancer. New 6beta,19-bridged steroid analogs of androstenedione, 6beta,19-epithio- and 6beta,19-methano compounds 11 and 17, were synthesized starting from 19
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a8159fcb1142dcdb8c9702faece0344
https://doi.org/10.1016/j.steroids.2009.06.001
https://doi.org/10.1016/j.steroids.2009.06.001
Autor:
Kouwa Yamashita, Takashi Hara, Takeshi Hirayama, Teruo Miyazaki, Tadashi Ikegami, Yasushi Matsuzaki, Mitsuteru Numazawa, Akira Honda
Publikováno v:
Journal of Lipid Research, Vol 50, Iss 10, Pp 2124-2130 (2009)
We describe a new sensitive and specific method for the quantification of serum malonate (malonic acid, MA), which could be a new biomarker for de novo lipogenesis (fatty acid synthesis). This method is based upon a stable isotope-dilution technique
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec18f4d4fdc587ddf5ed83b008c9b8c5
https://doi.org/10.1194/jlr.d800054-jlr200
https://doi.org/10.1194/jlr.d800054-jlr200
Autor:
Saki Ishikawa, Madoka Takahashi, Kouwa Yamashita, Wakako Handa, Mitsuteru Numazawa, Hiromi Umeta
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 116:191-199
To gain the structure-activity relationship of Delta(1)-androstenediones (Delta(1)-ADs) as mechanism-based inactivator of aromatase, series of 2-alkyl- and 2-alkoxy-substituted Delta(1)-ADs (6 and 9) as well as 2-bromo-Delta(1)-AD (14) were synthesiz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6adb6b330a75f054bbb72036d7911563
https://doi.org/10.1016/j.jsbmb.2009.05.015
https://doi.org/10.1016/j.jsbmb.2009.05.015