Zobrazeno 1 - 10
of 121
pro vyhledávání: '"Mitsuteru, Akahoshi"'
Autor:
Yuki Ishikawa, Nao Tanaka, Yoshihide Asano, Masanari Kodera, Yuichiro Shirai, Mitsuteru Akahoshi, Minoru Hasegawa, Takashi Matsushita, Kazuyoshi Saito, Sei-ichiro Motegi, Hajime Yoshifuji, Ayumi Yoshizaki, Tomohiro Kohmoto, Kae Takagi, Akira Oka, Miho Kanda, Yoshihito Tanaka, Yumi Ito, Kazuhisa Nakano, Hiroshi Kasamatsu, Akira Utsunomiya, Akiko Sekiguchi, Hiroaki Niiro, Masatoshi Jinnin, Katsunari Makino, Takamitsu Makino, Hironobu Ihn, Motohisa Yamamoto, Chisako Suzuki, Hiroki Takahashi, Emi Nishida, Akimichi Morita, Toshiyuki Yamamoto, Manabu Fujimoto, Yuya Kondo, Daisuke Goto, Takayuki Sumida, Naho Ayuzawa, Hidetoshi Yanagida, Tetsuya Horita, Tatsuya Atsumi, Hirahito Endo, Yoshihito Shima, Atsushi Kumanogoh, Jun Hirata, Nao Otomo, Hiroyuki Suetsugu, Yoshinao Koike, Kohei Tomizuka, Soichiro Yoshino, Xiaoxi Liu, Shuji Ito, Keiko Hikino, Akari Suzuki, Yukihide Momozawa, Shiro Ikegawa, Yoshiya Tanaka, Osamu Ishikawa, Kazuhiko Takehara, Takeshi Torii, Shinichi Sato, Yukinori Okada, Tsuneyo Mimori, Fumihiko Matsuda, Koichi Matsuda, Tiffany Amariuta, Issei Imoto, Keitaro Matsuo, Masataka Kuwana, Yasushi Kawaguchi, Koichiro Ohmura, Chikashi Terao
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Here we report the largest Asian genome-wide association study (GWAS) for systemic sclerosis performed to date, based on data from Japanese subjects and comprising of 1428 cases and 112,599 controls. The lead SNP is in the FCGR/FCRL region,
Externí odkaz:
https://doaj.org/article/2821292baef747248e9e487cef06ad07
Autor:
Miki Nakano, Masahiro Ayano, Kazuo Kushimoto, Shotaro Kawano, Kazuhiko Higashioka, Shoichiro Inokuchi, Hiroki Mitoma, Yasutaka Kimoto, Mitsuteru Akahoshi, Nobuyuki Ono, Yojiro Arinobu, Koichi Akashi, Takahiko Horiuchi, Hiroaki Niiro
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
Abstract CD226 is an activating receptor expressed on the cell surface of natural killer cells and T cells. Although CD226 polymorphism is known to be involved in systemic lupus erythematosus (SLE), the involvement of soluble CD226 (sCD226) in SLE is
Externí odkaz:
https://doaj.org/article/184c7d5b436a488e8be4ca2c72aa394a
Autor:
Masahiro Ayano, Yasutaka Kimoto, Hiroki Mitoma, Mitsuteru Akahoshi, Nobuyuki Ono, Yojiro Arinobu, Koichi Akashi, Takahiko Horiuchi, Hiroaki Niiro
Publikováno v:
Therapeutic Advances in Musculoskeletal Disease, Vol 14 (2022)
Background: Mizoribine (MZR) is an immunosuppressive agent that selectively inhibits inosine monophosphate dehydrogenase; its actions are considerably similar to those of mycophenolate mofetil (MMF). This study aimed to clarify whether MZR can be a g
Externí odkaz:
https://doaj.org/article/88097aa80184408989bd0aaa12d96d53
Autor:
Kazuhiko Higashioka, Yuri Ota, Takashi Maehara, Masafumi Moriyama, Masahiro Ayano, Hiroki Mitoma, Mitsuteru Akahoshi, Yojiro Arinobu, Takahiko Horiuchi, Seiji Nakamura, Koichi Akashi, Hiroaki Niiro
Publikováno v:
BMC Immunology, Vol 21, Iss 1, Pp 1-10 (2020)
Abstract Background Follicular helper CD4+ T (Tfh) cells have a critical role in IgG4 production by B cells in IgG4-related disease (IgG4-RD). Recent studies including ours showed that SLAMF7+CD4+ T cells are an important pathological driver of IgG4-
Externí odkaz:
https://doaj.org/article/51bc950deaf94dc994362e05f7fe1ae1
Autor:
Ayako Takaki-Kuwahara, Yojiro Arinobu, Kohta Miyawaki, Hisakata Yamada, Hirofumi Tsuzuki, Kensuke Irino, Masahiro Ayano, Yasutaka Kimoto, Hiroki Mitoma, Mitsuteru Akahoshi, Hiroshi Tsukamoto, Takahiko Horiuchi, Hiroaki Niiro, Koichi Akashi
Publikováno v:
Arthritis Research & Therapy, Vol 21, Iss 1, Pp 1-9 (2019)
Abstract Background Recent studies show that innate lymphoid cells (ILCs) contribute to the development of chronic inflammation and autoimmune disease. In this study, we assessed the ILC function in the development of rheumatoid arthritis (RA). Metho
Externí odkaz:
https://doaj.org/article/4bf8064b5623475e877e0314900a67f7
Autor:
Miki Nakano, Masahiro Ayano, Kazuo Kushimoto, Shotaro Kawano, Kazuhiko Higashioka, Shoichiro Inokuchi, Hiroki Mitoma, Yasutaka Kimoto, Mitsuteru Akahoshi, Nobuyuki Ono, Yojiro Arinobu, Koichi Akashi, Takahiko Horiuchi, Hiroaki Niiro
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
BackgroundCD226, an activating receptor expressed on the surface of natural killer (NK) cells and T cells, is also seen on B cells and CD226 polymorphism is associated with systemic lupus erythematosus (SLE). Because the specific roles of CD226+ B ce
Externí odkaz:
https://doaj.org/article/60435d1459ed459082a1816d2fbbd4c8
Autor:
Andriko Palmowski, Mitsuteru Akahoshi, Burkhard Muche, Zhivana Boyadzhieva, Sandra Hermann, Chikashi Terao, Edgar Wiebe, Frank Buttgereit
Publikováno v:
Rheumatology International. 43:903-909
Objective To investigate whether methotrexate (MTX) use is associated with bone mineral density (BMD) in patients with polymyalgia rheumatica (PMR) and various forms of vasculitis. Methods Rh-GIOP is a cohort study designed to evaluate bone health in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::20df9172c234d121dc65fb98d47ea892
https://doi.org/10.1007/s00296-023-05286-6
https://doi.org/10.1007/s00296-023-05286-6
Autor:
Qiaolei Wang, Daisuke Oryoji, Hiroki Mitoma, Yasutaka Kimoto, Masamichi Koyanagi, Kana Yokoyama, Masahiro Ayano, Mitsuteru Akahoshi, Yojiro Arinobu, Hiroaki Niiro, Koichi Akashi, Takahiko Horiuchi
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
BackgroundConcomitant use of methotrexate (MTX) improves the clinical efficacy of anti-TNF agents in the treatment of rheumatoid arthritis (RA). We aimed to clarify the cytotoxic effect of MTX on transmembrane TNF (tmTNF)-expressing cells treated wit
Externí odkaz:
https://doaj.org/article/06525f8fb220431090b3cde8369be2f3
Autor:
Masahiro Ayano, Hiroshi Tsukamoto, Hiroki Mitoma, Yasutaka Kimoto, Mitsuteru Akahoshi, Yojiro Arinobu, Toshihiro Miyamoto, Takahiko Horiuchi, Hiroaki Niiro, Koji Nagafuji, Mine Harada, Koichi Akashi
Publikováno v:
Arthritis Research & Therapy, Vol 21, Iss 1, Pp 1-8 (2019)
Abstract Background The effectiveness of autologous haematopoietic stem cell transplantation (auto-HSCT) in treating severe systemic sclerosis (SSc) is established; however, the necessity of purified CD34+ cell grafts and the appropriate conditioning
Externí odkaz:
https://doaj.org/article/5aedb78058f5425b97773ded08ccdfae
Autor:
Jin Nakagawa, Yoshinobu Koyama, Atsushi Kawakami, Yukitaka Ueki, Hiroshi Tsukamoto, Takahiko Horiuchi, Shuji Nagano, Ayumi Uchino, Toshiyuki Ota, Mitsuteru Akahoshi, Koichi Akashi
Publikováno v:
Arthritis Research & Therapy, Vol 19, Iss 1, Pp 1-9 (2017)
Abstract Background Currently, although several categories of biological disease-modifying antirheumatic drugs (bDMARDs) are available, there are few data informing selection of initial treatment for individual patients with rheumatoid arthritis (RA)
Externí odkaz:
https://doaj.org/article/a1896331038d484eb756fd15822375d4