Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Mitsuru Ono"'
Autor:
Yosuke Ando, Tetsuya Shimizugawa, Shigehito Takeshita, Mitsuru Ono, Mitsuru Shimamura, Ryuta Koishi, Hidehiko Furukawa
Publikováno v:
Journal of Lipid Research, Vol 44, Iss 6, Pp 1216-1223 (2003)
KK/Snk mice (previously KK/San) possessing a recessive mutation (hypl) of the angiopoietin-like 3 (Angptl3) gene homozygously exhibit a marked reduction of VLDL due to the decreased Angptl3 expression. Recently, we proposed that Angptl3 is a new clas
Externí odkaz:
https://doaj.org/article/ef70bc6f8cc7446198d5a12daad3b730
Publikováno v:
Journal of Lipid Research, Vol 43, Iss 11, Pp 1770-1772 (2002)
Studies with KK/San, obese and diabetic model mice having a unique hypotriglyceridemia phenotype, revealed that angiopoietin-like protein 3 (ANGPTL3) regulates lipid metabolism in mice. To determine the lipid-modulating role of other ANGPTLs, we focu
Externí odkaz:
https://doaj.org/article/299dfd8456164b91b1a21c6cf1b7c5ca
Autor:
Roxana Merino, Leandro Fernández-Pérez, Oscar M. Vidal, Gunnar Norstedt, Elizabeth Rico-Bautista, Peter Rotwein, Boris Lenhard, Amilcar Flores-Morales, Dennis J. Chia, Joachim Woelfle, Mitsuru Ono
Publikováno v:
Molecular Endocrinology. 21:293-311
The GH-activated signal transducer and activator of transcription 5b (STAT5b) is an essential regulator of somatic growth. The transcriptional response to STAT5b in liver is poorly understood. We have combined microarray-based expression profiling an
Autor:
Mylynda Schlesinger-Massart, Mitsuru Ono, Dennis J. Chia, Peter Rotwein, Honglin Jiang, Joachim Woelfle
Publikováno v:
Journal of Biological Chemistry. 281:3190-3197
A key agent in the anabolic actions of growth hormone (GH) is insulin-like growth factor-I (IGF-I), a 70-amino acid secreted protein with direct effects on somatic growth and tissue maintenance and repair. GH rapidly and potently stimulates IGF-I gen
Autor:
Akari Suzuki, Shinichi Yoshino, Akihiro Sekine, Xiaotian Chang, Yuta Kochi, Akihiko Mabuchi, Hidehiko Furukawa, Masakatsu Suzuki, Tatsuhiko Tsunoda, Tetsuji Sawada, Yusuke Nakamura, Susumu Saito, Shinya Tokuhiro, Kazuhiko Yamamoto, Masakazu Nagashima, Masahiko Ohtsuki, Miyuki Nagasaki, Mitsuru Ono, Atsushi Takahashi, Ryo Yamada
Publikováno v:
Nature Genetics. 35:341-348
Rheumatoid arthritis is a common inflammatory disease with complex genetic components. We investigated the genetic contribution of the cytokine gene cluster in chromosome 5q31 to susceptibility to rheumatoid arthritis in the Japanese population by ca
Autor:
Kenichi Yoshida, Mitsuru Shimamura, Tetsuya Shimizugawa, Mitsuru Ono, Hidehiko Furukawa, Chisa Noji-Sakikawa, Ryuta Koishi, Yosuke Ando
Publikováno v:
Journal of Biological Chemistry. 278:41804-41809
Angiopoietin-like 3 (ANGPTL3) is a secreted protein that is mainly expressed in the liver and regulates lipid metabolism by inhibiting the lipolysis of triglyceriderich lipoproteins. Using deletion mutants of human ANGPTL3, we demonstrated that the N
Autor:
Shinichi Yoshino, Miyuki Nagasaki, Masakatsu Suzuki, Ryota Teshima, Shigeto Tohma, Atsushi Takahashi, Kazuhiko Yamamoto, Tsukasa Matsubara, Shigeyuki Wakitani, Akihiro Sekine, Hidehiko Furukawa, Shinya Tokuhiro, Masahiko Ohtsuki, Aritoshi Iida, Makiko Nakayama-Hamada, Akari Suzuki, Ryo Yamada, Mitsuru Ono, Tetsuji Sawada, Xiaotian Chang, Yuichi Nishioka, Yusuke Nakamura, Masao Yukioka, Reimi Kawaida, Tatsuhiko Tsunoda
Publikováno v:
Nature Genetics. 34:395-402
Individuals with rheumatoid arthritis frequently have autoantibodies to citrullinated peptides, suggesting the involvement of the peptidylarginine deiminases citrullinating enzymes (encoded by PADI genes) in rheumatoid arthritis. Previous linkage stu
Autor:
Yukinobu Tohya, Kentaro Fujita, Yasushi Kawaguchi, Ken Maeda, Xuenan Xuan, Mitsuru Ono, Naoaki Yokoyama, Takeshi Mikami
Publikováno v:
Journal of Veterinary Medical Science. 59:1003-1009
Glycoprotein D (gD) of canine herpesvirus (CHV) YP2 strain was expressed in COS-7 and insect (Spodoptera frugiperda; Sf9) cells. The gDs expressed in COS-7 and Sf9 cells reacted with a panel of monoclonal antibodies (MAbs) against CHV gD (hemagglutin
Autor:
Yasushi Kawaguchi, Yukio Tokiyoshi, Naoaki Yokoyama, Katsunori Okazaki, Masahiro Niikura, Ken Maeda, Yukinobu Tohya, Takeshi Mikami, Mitsuru Ono
Publikováno v:
Virus Research. 46:75-80
We constructed a recombinant baculovirus expressing feline herpesvirus type I (FHV-1) gD in insect cells (Sf9 cells). The expressed product was identified as FHV-1 gD by a panel of monoclonal antibodies specific for the FHV-1 gD, and had an apparent
Autor:
Mitsuru Ono, S. Ishiguro, Yuji Fujikawa, Yasushi Kawaguchi, Yeon-Sil Shin, Naoaki Yokoyama, Ken Maeda, Yukinobu Tohya, Takeshi Mikami
Publikováno v:
Archives of Virology. 141:481-494
We constructed a recombinant feline herpesvirus type 1 (FHV-1) which was deleted in a defined region (450 bp) within the thymidine kinase (TK) gene (C7301dlTK) [Yokoyama et al. (1995) J Vet Med Sci 57: 709-714]. In this report, we carried out two exp