Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Mitsuru Ohkubo"'
Autor:
Yoshikazu Iwasawa, Hidehito Kotani, Mitsuru Ohkubo, Nobuhiko Kawanishi, Satomi Miki, Ikuko Takahashi, Mayu Miyamoto, Tadahiro Nambu, Takumi Sakai, Tsutomu Kodera, Koji Ichikawa, Takashi Mita, Yoko Nakatsuru, Shinichi Hasako, Toshiyasu Shimomura
Supplementary Figure 1 from MK-5108, a Highly Selective Aurora-A Kinase Inhibitor, Shows Antitumor Activity Alone and in Combination with Docetaxel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b079111e339740d4c7ac9bebcc68c05
https://doi.org/10.1158/1535-7163.22484802
https://doi.org/10.1158/1535-7163.22484802
Autor:
Yoshikazu Iwasawa, Hidehito Kotani, Mitsuru Ohkubo, Nobuhiko Kawanishi, Satomi Miki, Ikuko Takahashi, Mayu Miyamoto, Tadahiro Nambu, Takumi Sakai, Tsutomu Kodera, Koji Ichikawa, Takashi Mita, Yoko Nakatsuru, Shinichi Hasako, Toshiyasu Shimomura
Supplementary Figure 2 from MK-5108, a Highly Selective Aurora-A Kinase Inhibitor, Shows Antitumor Activity Alone and in Combination with Docetaxel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b109bd2db35e12595e9b53c3a27e7b8
https://doi.org/10.1158/1535-7163.22484799
https://doi.org/10.1158/1535-7163.22484799
Autor:
Yoshikazu Iwasawa, Hidehito Kotani, Mitsuru Ohkubo, Nobuhiko Kawanishi, Satomi Miki, Ikuko Takahashi, Mayu Miyamoto, Tadahiro Nambu, Takumi Sakai, Tsutomu Kodera, Koji Ichikawa, Takashi Mita, Yoko Nakatsuru, Shinichi Hasako, Toshiyasu Shimomura
Aurora-A kinase is a one of the key regulators during mitosis progression. Aurora-A kinase is a potential target for anticancer therapies because overexpression of Aurora-A, which is frequently observed in some human cancers, results in aberrant mito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0e842eade4bbd48bf75c4ab6800c1f0
https://doi.org/10.1158/1535-7163.c.6531594.v1
https://doi.org/10.1158/1535-7163.c.6531594.v1
Autor:
Yoshikazu Iwasawa, Hidehito Kotani, Mitsuru Ohkubo, Nobuhiko Kawanishi, Satomi Miki, Ikuko Takahashi, Mayu Miyamoto, Tadahiro Nambu, Takumi Sakai, Tsutomu Kodera, Koji Ichikawa, Takashi Mita, Yoko Nakatsuru, Shinichi Hasako, Toshiyasu Shimomura
Supplementary Table 1 from MK-5108, a Highly Selective Aurora-A Kinase Inhibitor, Shows Antitumor Activity Alone and in Combination with Docetaxel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22f10b3cadb9942618b8e754662d271c
https://doi.org/10.1158/1535-7163.22484796.v1
https://doi.org/10.1158/1535-7163.22484796.v1
Publikováno v:
Journal of Spacecraft and Rockets. 58:619-627
In the discharge ground tests of satellites, an electron beam is mainly used to simulate the electron environment on geostationary orbit; however, the insulator is charged on the orbit by photoelec...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d39ce2827c44151d5bde417f021d6af
https://doi.org/10.2514/1.a34880
https://doi.org/10.2514/1.a34880
Autor:
Satoshi Yamashita, Chihoko Yoshimura, Shuichi Ohkubo, Takashi Mizutani, Mitsuru Ohkubo, Khoon Tee Chong, Kaoru Funabashi, Takao Uno, Hiromi Muraoka, Yuichi Kawai, Yasuo Kodama, Kazuhiko Shigeno, Hiromi Oshiumi, Tatsuya Suzuki, Koichi Takahashi, Makoto Kitade
Publikováno v:
Journal of medicinal chemistry. 62(2)
The molecular chaperone heat shock protein 90 (HSP90) is a promising target for cancer therapy, as it assists in the stabilization of cancer-related proteins, promoting cancer cell growth, and survival. A novel series of HSP90 inhibitors were discove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::067f9e2751a7e4afd00aa757032f573c
https://pubmed.ncbi.nlm.nih.gov/30525599
https://pubmed.ncbi.nlm.nih.gov/30525599
Autor:
Takashi Tojo, Kousei Yoshihara, Mitsuru Ohkubo, Akira Nagashima, Hiroshi Miyake, Masataka Morita, Ayako Moritomo, Takayuki Inoue
Publikováno v:
Bioorganic & Medicinal Chemistry. 21:1219-1233
Vascular adhesion protein-1 (VAP-1), an amine oxidase that is also known as a semicarbazide-sensitive amine oxidase (SSAO), is present in particularly high levels in human plasma, and is considered a potential therapeutic target for various inflammat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cc53d691c6783a0508c9249779b39c4
https://doi.org/10.1016/j.bmc.2012.12.025
https://doi.org/10.1016/j.bmc.2012.12.025
Autor:
Satoshi Sunami, Mitsuru Ohkubo
Publikováno v:
Tetrahedron. 65:638-643
An efficient method for the solid-phase synthesis of aryl amines, heteroaryl amines, and sterically hindered alkyl amines has been developed. The key step in this process was the formation of resin-bound carbamates ( B ) by the Curtius rearrangement
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6345872f6b6b4602e20178a02d31cd39
https://doi.org/10.1016/j.tet.2008.11.012
https://doi.org/10.1016/j.tet.2008.11.012
Autor:
Hideki Kurihara, Hisashi Ohta, Aki Kawagishi, Masayuki Nakamura, Morihiro Mitsuya, Gentaroh Suzuki, Naohiro Tsukamoto, Hiroshi Fushiki, Mitsuru Ohkubo
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 323:147-156
Novel isoxazolopyridone derivatives that are metabotropic glutamate receptor (mGluR) 7 antagonists were discovered and pharmacologically characterized. 5-Methyl-3,6-diphenylisoxazolo[4,5- c ]pyridin-4(5 H )-one (MDIP) was identified by random screeni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc0ca64032631f3f52fe8e63152786ee
https://doi.org/10.1124/jpet.107.124701
https://doi.org/10.1124/jpet.107.124701
Autor:
Kouji Hattori, Kayoko Mihara, Takayoshi Kinoshita, Kazunori Kamijo, Hirofumi Yamamoto, Yoshiyuki Kido, Hiroshi Miyake, Masaichi Warizaya, Junya Ishida, Nobuya Matsuoka, Akinori Iwashita, Kenji Murano, Mitsuru Ohkubo
Publikováno v:
Bioorganic & Medicinal Chemistry. 14:1378-1390
We disclose herein our efforts aimed at discovery of selective PARP-1 and PARP-2 inhibitors. We have recently discovered several novel classes of quinazolinones, quinazolidinones, and quinoxalines as potent PARP-1 inhibitors, which may represent attr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c509e2b1109ed4caaeed6c285329dccd
https://doi.org/10.1016/j.bmc.2005.09.061
https://doi.org/10.1016/j.bmc.2005.09.061