Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Mitsuru NOTOYA"'
Autor:
Mitsuru Notoya, Hiroyuki Takagi, Yutaka Tonomura, Hideo Yukioka, Kohji Abe, Shingo Sakamoto, Sotaro Momosaki, Atsuyuki Shimazaki, Keiichi Tanimoto
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 372(3)
Excess intramyocellular lipid (IMCL) deposition in skeletal muscle is closely associated with insulin resistance. Pharmacological inhibition of acetyl-CoA carboxylase (ACC) 2 offers a promising approach to treat insulin resistance through stimulation
Autor:
Hiroyuki Takagi, Kumi Hashimoto, Atsuyuki Shimazaki, Tatsuya Ikehara, Yuji Nishiura, Hideo Yukioka, Mitsuru Notoya, Yuto Kashiwagi
Publikováno v:
Diabetes. 68
Intramyocellular lipid (IMCL) accumulation in skeletal muscle is closely associated with the development of insulin resistance. In particular, bioactive lipids such as diacylglycerol (DAG) and ceramide (Cer) have great impact on muscle insulin action
Autor:
Nobuteru Akiyama, Shogo Oka, Isamu Nanchi, Tetsuya Kouno, Mitsuru Notoya, Hideo Yukioka, Tomohiko Okuda, Takahito Ito
Publikováno v:
Journal of Endocrinology. 228:115-125
Ghrelin is an appetite-stimulating hormone secreted from stomach. Since the discovery that acylation of the serine-3 residue by ghrelin O-acyltransferase (GOAT) is essential for exerting its functions, GOAT has been regarded as an therapeutic target
Autor:
Nobuteru Akiyama, Hideo Yukioka, Isamu Nanchi, Tomohiko Okuda, Kumiko Fujieda, Mitsuru Notoya, Tetsuya Kouno, Takahito Ito, Takanori Iwasaki
Publikováno v:
Endocrine journal. 64
The octanoyl modification of ghrelin by ghrelin O-acyltransferase (GOAT) is essential for exerting its physiologic actions. Since exogenous acylated-ghrelin has shown to stimulate food intake in humans and rodents, GOAT has been regarded as a promisi
Autor:
Kohji Hanasaki, Yuko Akiyama, Kenzo Funatsuki, Kenji Asakura, Mitsuru Notoya, Nobuteru Akiyama, Toru Yanagimoto, Tatsuo Kobayashi, Hideaki Katoh, Sachiko Yamamoto, Toshihiro Shinosaki
Publikováno v:
European Journal of Pharmacology. 649:23-28
Irbesartan, an angiotensin II type 1 receptor blocker has been reported to alleviate metabolic disorder in animal studies and human clinical trials. Although this effect may be related to the ability of irbesartan to serve as a partial agonist for th
Publikováno v:
Nephron Experimental Nephrology. 113:e89-e96
Background/Aims: Morphological change of podocytes is closely correlated with the development of proteinuria. Podocalyxin is a major sialoglycoprotein of the podocytes and is thought to be involved in the maintenance of the foot processes structure.
Autor:
Sara Conti, Masao Masui, G. Li Volti, Roger M. Mason, Giuseppe Remuzzi, Rossella Bianchi, Martin Petrucci, Marco Campana, Luigi Fabrizio Rodella, Masashi Ito, Ariela Benigni, Nadia Abdel Wahab, Shan Yan Lin, Diego Gazzolo, Hideki Tanioka, Roberto Motterlini, Steve Ledbetter, Daniela Corna, C. Di Giacomo, Yves Paquette, François A. Leblond, Elena Gagliardini, Hui Lin, Toshihiro Shinosaki, Alain Bonnardeaux, Daniela Rottoli, Xiang Ming Qi, Elisa Borsani, Yong Gui Wu, Guo Zhong Wu, Masashi Nishida, Rita Rezzani, Carla Zoja, Mitsuru Notoya, Vincent Pichette, Ji Jia Shen, Takayuki Kuroda, Fabio Sangalli, Kenji Hamaoka
Publikováno v:
Nephron Experimental Nephrology. 104:e185-e188
Autor:
Toshihiro Shinosaki, Masao Masui, Takayuki Kuroda, Mitsuru Notoya, Masashi Ito, Hideki Tanioka
Publikováno v:
Nephron Experimental Nephrology. 104:e169-e182
Background/Aim: Matrix production and degradation are critically important in chronic nephritis. Our aim was to investigate the precise expression of matrix-related molecules which is essential for understanding the pathogenesis of renal disease. Met
Autor:
Takayoshi Yoshikawa, Masahiro Sakagami, Kazutoshi Horie, Kazuyoshi Masuda, Koichiro Hirano, Hiroshi Hamana, Mitsuru Notoya
Publikováno v:
Biological and Pharmaceutical Bulletin. 27:1275-1280
We have previously found that carboxymethylpullulan (CMPul) conjugated with sialyl Lewis X (Neu5Acalpha2-3Galbeta1-4(Fucalpha1-3)GlcNAc-, 2-3SLex) preferentially accumulates in the lymph nodes and spleen. In the present study, we investigated the str