Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Mitsuru Morimoto"'
Autor:
Yasunori Enomoto, Hiroaki Katsura, Takashi Fujimura, Akira Ogata, Saori Baba, Akira Yamaoka, Miho Kihara, Takaya Abe, Osamu Nishimura, Mitsutaka Kadota, Daisuke Hazama, Yugo Tanaka, Yoshimasa Maniwa, Tatsuya Nagano, Mitsuru Morimoto
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract The molecular etiology of idiopathic pulmonary fibrosis (IPF) has been extensively investigated to identify new therapeutic targets. Although anti-inflammatory treatments are not effective for patients with IPF, damaged alveolar epithelial c
Externí odkaz:
https://doaj.org/article/0db6ad10f90f44be9f24273431ff8e36
Autor:
Keiju Sato, Naoki Hayashi, Takahiro Ito, Noriyuki Masago, Makoto Takamura, Mitsuru Morimoto, Takuji Maekawa, Doyoon Lee, Kuan Qiao, Jeehwan Kim, Keisuke Nakagahara, Katsunori Wakabayashi, Hiroki Hibino, Wataru Norimatsu
Publikováno v:
Communications Materials, Vol 2, Iss 1, Pp 1-6 (2021)
Magic-angle twisted bilayer graphene is interesting for its correlated superconducting and insulating states, but samples are typically micrometer-scale. Here, 3 × 5 mm2 twisted bilayer graphene samples are fabricated, exhibiting a flat band and lar
Externí odkaz:
https://doaj.org/article/8d2ee33cf066431b8aa45e2fbdac013c
Autor:
Satomi Yogosawa, Makiko Ohkido, Takuro Horii, Yasumasa Okazaki, Jun Nakayama, Saishu Yoshida, Shinya Toyokuni, Izuho Hatada, Mitsuru Morimoto, Kiyotsugu Yoshida
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
Yogosawa et al find that mice lacking the Dyrk2 kinase display congenital malformations in multiple organs and die from respiratory failure associated with disrupted lung mesenchyme and reduced expression of Foxf1. Using an ex vivo lung culture syste
Externí odkaz:
https://doaj.org/article/da3e0f2357804a94ad84e5295d570694
Autor:
Noridzzaida Ridzuan, Norashikin Zakaria, Darius Widera, Jonathan Sheard, Mitsuru Morimoto, Hirofumi Kiyokawa, Seoparjoo Azmel Mohd Isa, Gurjeet Kaur Chatar Singh, Kong-Yong Then, Ghee-Chien Ooi, Badrul Hisham Yahaya
Publikováno v:
Stem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-21 (2021)
Abstract Background Chronic obstructive pulmonary disease (COPD) is an incurable and debilitating chronic disease characterized by progressive airflow limitation associated with abnormal levels of tissue inflammation. Therefore, stem cell-based appro
Externí odkaz:
https://doaj.org/article/b578f88ff1d740f1ac709eb36548bdc2
Autor:
Keishi Kishimoto, Kana T. Furukawa, Agustin Luz-Madrigal, Akira Yamaoka, Chisa Matsuoka, Masanobu Habu, Cantas Alev, Aaron M. Zorn, Mitsuru Morimoto
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
How murine tracheal mesenchyme is specified during development is unclear. Here, the authors show a Wnt pathway target, Tbx4, is needed but this is regulated by Wnt signals from neighbouring tracheal epithelial cells, and take advantage of this knowl
Externí odkaz:
https://doaj.org/article/b0fc5e624a2e420cabcc656783db13c2
Autor:
Lu Han, Praneet Chaturvedi, Keishi Kishimoto, Hiroyuki Koike, Talia Nasr, Kentaro Iwasawa, Kirsten Giesbrecht, Phillip C. Witcher, Alexandra Eicher, Lauren Haines, Yarim Lee, John M. Shannon, Mitsuru Morimoto, James M. Wells, Takanori Takebe, Aaron M. Zorn
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
The fetal murine foregut develops into visceral organs via interactions between the mesoderm and endoderm, but how is unclear. Here, the authors use single cell RNAseq to show a diversity in organ specific splanchnic mesoderm cell-types, infer a sign
Externí odkaz:
https://doaj.org/article/0ee51be150a74c26a536081300641197
Publikováno v:
Disease Models & Mechanisms, Vol 13, Iss 12 (2020)
Mammalian lungs have the ability to recognize external environments by sensing different compounds in inhaled air. Pulmonary neuroendocrine cells (PNECs) are rare, multi-functional epithelial cells currently garnering attention as intrapulmonary sens
Externí odkaz:
https://doaj.org/article/426d0f6f1a09480f86eb01b89cf8c7f7
Autor:
Keishi Kishimoto, Masaru Tamura, Michiru Nishita, Yasuhiro Minami, Akira Yamaoka, Takaya Abe, Mayo Shigeta, Mitsuru Morimoto
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Tracheal development arises due to tube morphogenesis but how this is regulated is unclear. Here, the authors identify polarization of smooth muscle progenitors as controlling murine tracheal development, activating noncanonical Wnt signaling followe
Externí odkaz:
https://doaj.org/article/010cb63b7bb24d288070b261e2b6a9a1
Autor:
Wenguang Yin, Hyun-Taek Kim, ShengPeng Wang, Felix Gunawan, Lei Wang, Keishi Kishimoto, Hua Zhong, Dany Roman, Jens Preussner, Stefan Guenther, Viola Graef, Carmen Buettner, Beate Grohmann, Mario Looso, Mitsuru Morimoto, Graeme Mardon, Stefan Offermanns, Didier Y. R. Stainier
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Tubulogenesis is required for the formation of many internal structures including the trachea. Here, the authors show that the potassium channel KCNJ13 regulates tracheal tube formation, with shorter tracheas forming in mutant mice due in part to cha
Externí odkaz:
https://doaj.org/article/5c7dc446a7fa45a0a6142c125ca9449f
Publikováno v:
Cell Reports, Vol 13, Iss 12, Pp 2679-2686 (2015)
The airway epithelium consists of diverse cell types, including neuroendocrine (NE) cells. These cells are thought to function as chemoreceptors and as a component of the stem cell niche as well as the cells of origin in small-cell lung cancer. NE ce
Externí odkaz:
https://doaj.org/article/ce54cc92cd6748b499df3df9fb20d409