Zobrazeno 1 - 10
of 270
pro vyhledávání: '"Mitsuru Ishikawa"'
Autor:
Yusuke Masano, Chika Saegusa, Mitsuru Ishikawa, Tatsuo Matsunaga, Hideyuki Okano, Masato Fujioka
Publikováno v:
Stem Cell Research, Vol 78, Iss , Pp 103452- (2024)
We report the establishment of a human induced pluripotent stem cell (iPSC) line from a 54-year-old male patient with an A1555G mutation in the mitochondrial 12S ribosomal RNA gene (MTRNR1), associated with sensorineural hearing loss. The established
Externí odkaz:
https://doaj.org/article/a3fc1b1467a04b1eabb9cad2805855bd
Autor:
Ryohei Takada, Michihiro Toritsuka, Takahira Yamauchi, Rio Ishida, Yoshinori Kayashima, Yuki Nishi, Mitsuru Ishikawa, Kazuhiko Yamamuro, Minobu Ikehara, Takashi Komori, Yuki Noriyama, Kohei Kamikawa, Yasuhiko Saito, Hideyuki Okano, Manabu Makinodan
Publikováno v:
Molecular Autism, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Background A growing body of evidence suggests that immune dysfunction and inflammation in the peripheral tissues as well as the central nervous system are associated with the neurodevelopmental deficits observed in autism spectrum disorder
Externí odkaz:
https://doaj.org/article/d4371887269c4db7bf95d1b63ee05347
Autor:
Emi Qian, Masahiro Uemura, Hiroya Kobayashi, Shiho Nakamura, Fumiko Ozawa, Sho Yoshimatsu, Mitsuru Ishikawa, Osamu Onodera, Satoru Morimoto, Hideyuki Okano
Publikováno v:
Inflammation and Regeneration, Vol 43, Iss 1, Pp 1-10 (2023)
Abstract Cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL) is an inherited cerebral small vessel disease (CSVD) caused by biallelic mutations in the high-temperature requirement serine peptidase A1
Externí odkaz:
https://doaj.org/article/f2d5916618a74664bb6b7b4455d350a4
Autor:
Tsubasa Saeki, Sho Yoshimatsu, Mitsuru Ishikawa, Chung-Chau Hon, Ikuko Koya, Shinsuke Shibata, Makoto Hosoya, Chika Saegusa, Kaoru Ogawa, Jay W. Shin, Masato Fujioka, Hideyuki Okano
Publikováno v:
Regenerative Therapy, Vol 20, Iss , Pp 165-186 (2022)
Introduction: Efficient induction of the otic placode, the developmental origin of the inner ear from human pluripotent stem cells (hPSCs), provides a robust platform for otic development and sensorineural hearing loss modelling. Nevertheless, there
Externí odkaz:
https://doaj.org/article/8f164e0c0729489aa06876e4cf1c3290
Autor:
Tosho Kondo, Ihori Ebinuma, Hirotaka Tanaka, Yukitoshi Nishikawa, Takaki Komiya, Mitsuru Ishikawa, Hideyuki Okano
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 8, p 6987 (2023)
Amyotrophic lateral sclerosis (ALS) is a major life-threatening disease caused by motor neuron degeneration. More effective treatments through drug discovery are urgently needed. Here, we established an effective high-throughput screening system usin
Externí odkaz:
https://doaj.org/article/66b534a3974b4a22886ea95663fe9487
Publikováno v:
ACS Omega, Vol 5, Iss 16, Pp 9605-9613 (2020)
Externí odkaz:
https://doaj.org/article/3df7e7d30d7842928a11b337359353d8
Autor:
Zhi Zhou, Sho Yoshimatsu, Emi Qian, Mitsuru Ishikawa, Tsukika Sato, Manami Ohtaka, Mahito Nakanishi, Hideyuki Okano
Publikováno v:
Stem Cell Research, Vol 56, Iss , Pp 102549- (2021)
The defective and persistent Sendai virus (SeVdp) vector system allows efficient generation of transgene-free induced pluripotent stem cells (iPSCs) from human somatic cells. By leveraging the system, here we report the generation of an iPSC line fro
Externí odkaz:
https://doaj.org/article/85223001cf0443e4a91e4d526182fb88
Autor:
Masahiro Nogami, Mitsuru Ishikawa, Atsushi Doi, Osamu Sano, Takefumi Sone, Tetsuya Akiyama, Masashi Aoki, Atsushi Nakanishi, Kazuhiro Ogi, Masato Yano, Hideyuki Okano
Publikováno v:
Neurobiology of Disease, Vol 155, Iss , Pp 105364- (2021)
Summary: Fused in sarcoma/translated in liposarcoma (FUS) is a causative gene of amyotrophic lateral sclerosis (ALS). Mutated FUS causes accumulation of DNA damage and cytosolic stress granule (SG) formation, thereby motor neuron (MN) death. However,
Externí odkaz:
https://doaj.org/article/1410dd69c2fd495e97b6d914072ba267
Publikováno v:
Stem Cell Research, Vol 53, Iss , Pp 102380- (2021)
Epstein-Barr virus (EBV)-based episomal vector system enables persistent transgene expression, which is advantageous for efficient derivation of transgene-free induced pluripotent stem cells (iPSCs) without viral transduction. Here, we report establi
Externí odkaz:
https://doaj.org/article/18b8eac0eeb741619944f6736fa9206f
Autor:
Tetsuya Akiyama, Naoki Suzuki, Mitsuru Ishikawa, Koki Fujimori, Takefumi Sone, Jiro Kawada, Ryo Funayama, Fumiyoshi Fujishima, Shio Mitsuzawa, Kensuke Ikeda, Hiroya Ono, Tomomi Shijo, Shion Osana, Matsuyuki Shirota, Tadashi Nakagawa, Yasuo Kitajima, Ayumi Nishiyama, Rumiko Izumi, Satoru Morimoto, Yohei Okada, Takayuki Kamei, Mayumi Nishida, Masahiro Nogami, Shohei Kaneda, Yoshiho Ikeuchi, Hiroaki Mitsuhashi, Keiko Nakayama, Teruo Fujii, Hitoshi Warita, Hideyuki Okano, Masashi Aoki
Publikováno v:
EBioMedicine, Vol 45, Iss , Pp 362-378 (2019)
Background: The characteristic structure of motor neurons (MNs), particularly of the long axons, becomes damaged in the early stages of amyotrophic lateral sclerosis (ALS). However, the molecular pathophysiology of axonal degeneration remains to be f
Externí odkaz:
https://doaj.org/article/09b1c2d9afee403f938bc1b807d2caa6