Zobrazeno 1 - 10
of 124
pro vyhledávání: '"Mitsuru, Shinohara"'
Autor:
Yukiko Nishita, Giovanni Sala, Mitsuru Shinohara, Chikako Tange, Fujiko Ando, Hiroshi Shimokata, Naoyuki Sato, Rei Otsuka
Publikováno v:
Experimental Gerontology, Vol 171, Iss , Pp 112036- (2023)
Background and aims: Carriers of the apolipoprotein E ε4 allele (APOEɛ4) have an increased risk of developing dementia (e.g., Alzheimer's disease). However, it is less clear whether the APOEɛ4 might also be involved in cognitive aging among the no
Externí odkaz:
https://doaj.org/article/97ff2c061a6c4ea5aa411dfae906adff
Autor:
Mitsuru Shinohara, Masataka Kikuchi, Miyuki Onishi‐Takeya, Yoshitaka Tashiro, Kaoru Suzuki, Yasuhiro Noda, Shuko Takeda, Masahiro Mukouzono, Seiichi Nagano, Akio Fukumori, Ryuichi Morishita, Akihiro Nakaya, Naoyuki Sato
Publikováno v:
FASEB BioAdvances, Vol 3, Iss 5, Pp 323-333 (2021)
Abstract Clinical studies have indicated that obesity and diabetes are associated with Alzheimer's disease (AD) and neurodegeneration. However, the mechanism by which obesity/diabetes and AD interact with each other and contribute to dementia remains
Externí odkaz:
https://doaj.org/article/14add0dde46f4712afdc24c83ff4af10
Autor:
Akira Yokomizo, Hirofumi Koga, Kazuto Ito, Yutaka Takezawa, Motokiyo Komiyama, Kazuo Nishimura, Junji Yonese, Katsuyoshi Hashine, Naoya Masumori, Gaku Arai, Shiro Saito, Mitsuru Shinohara, Nobuaki Shimizu, Atsushi Yamauchi, Takefumi Satoh, Tatsuo Tochigi, Mikio Kobayashi, Hiroyuki Fujimoto, Ken‐ichi Kakimoto, Iwao Fukui, Taiji Tsukamoto, Miwako Nozaki, Katsuyuki Karasawa, Masaru Hasumi, Mikinobu Ohtani, Hiromichi Ishiyama, Masaaki Kuwahara, Masaoki Harada, Yasuo Ohashi, Toshihiko Kotake, Tadao Kakizoe, Kazuhiro Suzuki, Seiji Naito, Hidetoshi Yamanaka, National Research Project on Endocrine‐Radiation Combination Therapy for Locally Advanced Prostate Cancer investigators
Publikováno v:
Cancer Medicine, Vol 10, Iss 10, Pp 3240-3248 (2021)
Abstract Background We evaluated patient‐reported outcomes (PRO) during neoadjuvant androgen deprivation therapy (ADT) plus external beam radiation therapy (EBRT) followed by either adjuvant continuous ADT (CADT) or intermittent ADT (IADT) for pati
Externí odkaz:
https://doaj.org/article/4fc6d5a819fc4ff3b13b667c17fde309
Autor:
Kaoru Suzuki, Mitsuru Shinohara, Yoshihiro Uno, Yoshitaka Tashiro, Ghupurjan Gheni, Miho Yamamoto, Akio Fukumori, Akihiko Shindo, Tomoji Mashimo, Hidekazu Tomimoto, Naoyuki Sato
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-15 (2021)
Abstract Background Subcortical ischemic vascular dementia, one of the major subtypes of vascular dementia, is characterized by lacunar infarcts and white matter lesions caused by chronic cerebral hypoperfusion. In this study, we used a mouse model o
Externí odkaz:
https://doaj.org/article/f5a8d39b5eb14f19942f7849b5a5bc6d
Publikováno v:
Molecular Neurodegeneration, Vol 15, Iss 1, Pp 1-19 (2020)
Abstract Investigations of apolipoprotein E (APOE) gene, the major genetic risk modifier for Alzheimer’s disease (AD), have yielded significant insights into the pathogenic mechanism. Among the three common coding variants, APOE*ε4 increases, wher
Externí odkaz:
https://doaj.org/article/36de4881a3f6494a83af09590ed383ae
Autor:
Li Zhong, Ying Xu, Rengong Zhuo, Tingting Wang, Kai Wang, Ruizhi Huang, Daxin Wang, Yue Gao, Yifei Zhu, Xuan Sheng, Kai Chen, Na Wang, Lin Zhu, Dan Can, Yuka Marten, Mitsuru Shinohara, Chia-Chen Liu, Dan Du, Hao Sun, Lei Wen, Huaxi Xu, Guojun Bu, Xiao-Fen Chen
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
TREM2 is a genetic risk factor for Alzheimer’s disease, and soluble TREM2 (sTREM2) in the CSF correlates with AD progression. Here the authors study the role of sTREM2 in a mouse model of Alzheimer’s disease, and find it reduces amyloid accumulat
Externí odkaz:
https://doaj.org/article/b52435dfcf7a4d5aa13e0d196ad259a1
Autor:
Mitsuru Shinohara, Takahisa Kanekiyo, Masaya Tachibana, Aishe Kurti, Motoko Shinohara, Yuan Fu, Jing Zhao, Xianlin Han, Patrick M Sullivan, G William Rebeck, John D Fryer, Michael G Heckman, Guojun Bu
Publikováno v:
eLife, Vol 9 (2020)
Although the ε2 allele of apolipoprotein E (APOE2) benefits longevity, its mechanism is not understood. The protective effects of the APOE2 on Alzheimer’s disease (AD) risk, particularly through their effects on amyloid or tau accumulation, may co
Externí odkaz:
https://doaj.org/article/546486e15f5a428a8f12cebb5e03daec
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 12, Iss 1, Pp n/a-n/a (2020)
Abstract Introduction Although diabetes and apolipoprotein E (apoE) are both significant risk factors for dementia, including Alzheimer's disease, it remains to be clarified how they are related to each other in contributing to the risk of dementia.
Externí odkaz:
https://doaj.org/article/bc753068d3e642b78eea2696af3739fa
Autor:
Na Zhao, Chia-Chen Liu, Alexandra J. Van Ingelgom, Cynthia Linares, Aishe Kurti, Joshua A. Knight, Michael G. Heckman, Nancy N. Diehl, Mitsuru Shinohara, Yuka A. Martens, Olivia N. Attrebi, Leonard Petrucelli, John D. Fryer, Zbigniew K. Wszolek, Neill R. Graff-Radford, Richard J. Caselli, Monica Y. Sanchez-Contreras, Rosa Rademakers, Melissa E. Murray, Shunsuke Koga, Dennis W. Dickson, Owen A. Ross, Guojun Bu
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
The APOE ε4 allele is a strong genetic risk factor for Alzheimer’s disease, whereas the APOE ε2 allele is protective. Here the authors show that mice expressing the human APOE ε2/ε2 genotype have increased tau pathology and related behavioral d
Externí odkaz:
https://doaj.org/article/47acaeff9b2f4fb58aa35f26dc4d2d72
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 7, Pp 1267-1281 (2017)
Among the LDL receptor (LDLR) family members, the roles of LDLR-related protein (LRP)1 in the pathogenesis of Alzheimer's disease (AD), especially late-onset AD, have been the most studied by genetic, neuropathological, and biomarker analyses (clinic
Externí odkaz:
https://doaj.org/article/adc93731ae984bd994d7bbe7d3ac9fa7