Zobrazeno 1 - 10
of 512
pro vyhledávání: '"Mitsuo Oshimura"'
Autor:
Narumi Uno, Hiroyuki Satofuka, Hitomaru Miyamoto, Kazuhisa Honma, Teruhiko Suzuki, Kyotaro Yamazaki, Ryota Ito, Takashi Moriwaki, Shusei Hamamichi, Kazuma Tomizuka, Mitsuo Oshimura, Yasuhiro Kazuki
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 33, Iss , Pp 391-403 (2023)
Microcell-mediated chromosome transfer is an attractive technique for transferring chromosomes from donor cells to recipient cells and has enabled the generation of cell lines and humanized animal models that contain megabase-sized gene(s). However,
Externí odkaz:
https://doaj.org/article/6a1d3237830545f0abde19627d69f0ec
Autor:
Yosuke Hiramuki, Satoshi Abe, Narumi Uno, Kanako Kazuki, Shuta Takata, Hitomaru Miyamoto, Haruka Takayama, Kayoko Morimoto, Shoko Takehara, Mitsuhiko Osaki, Jun Tanihata, Shin’ichi Takeda, Kazuma Tomizuka, Mitsuo Oshimura, Yasuhiro Kazuki
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-8 (2023)
Abstract Dystrophin maintains membrane integrity as a sarcolemmal protein. Dystrophin mutations lead to Duchenne muscular dystrophy, an X-linked recessive disorder. Since dystrophin is one of the largest genes consisting of 79 exons in the human geno
Externí odkaz:
https://doaj.org/article/232b2a6750bd4df6b4d27f2d86136a45
Autor:
Hiroyuki Satofuka, Yayan Wang, Kyotaro Yamazaki, Shusei Hamamichi, Takeshi Fukuhara, Abdur Rafique, Nana Osako, Iori Kanazawa, Takeshi Endo, Naomi Miyake, Kazuhisa Honma, Yuichi Nagashima, Genki Hichiwa, Kazuto Shimoya, Satoshi Abe, Takashi Moriwaki, Yasufumi Murakami, Xu Gao, Hiroyuki Kugoh, Mitsuo Oshimura, Yuji Ito, Yasuhiro Kazuki
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract We previously generated fully human antibody-producing TC-mAb mice for obtaining potential therapeutic monoclonal antibodies (mAbs). In this study, we investigated 377 clones of fully human mAbs against a tumor antigen, epithelial cell adhes
Externí odkaz:
https://doaj.org/article/fb5f52237457428e8d9321f244d2301d
Autor:
Shotaro Uehara, Yuichi Iida, Miyuki Ida-Tanaka, Motohito Goto, Kenji Kawai, Masafumi Yamamoto, Yuichiro Higuchi, Satoshi Ito, Riichi Takahashi, Hidetaka Kamimura, Mamoru Ito, Hiroshi Yamazaki, Mitsuo Oshimura, Yasuhiro Kazuki, Hiroshi Suemizu
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Chimeric TK-NOG mice with a humanized liver (normal Hu-liver) are a unique animal model for predicting drug metabolism in humans. However, residual mouse hepatocytes occasionally prevent the precise evaluation of human drug metabolism. Herei
Externí odkaz:
https://doaj.org/article/1d62c1e9eb1d4e0588116996e7c1f13d
Autor:
Dylan C Sarver, Cheng Xu, Susana Rodriguez, Susan Aja, Andrew E Jaffe, Feng J Gao, Michael Delannoy, Muthu Periasamy, Yasuhiro Kazuki, Mitsuo Oshimura, Roger H Reeves, G William Wong
Publikováno v:
eLife, Vol 12 (2023)
The consequences of aneuploidy have traditionally been studied in cell and animal models in which the extrachromosomal DNA is from the same species. Here, we explore a fundamental question concerning the impact of aneuploidy on systemic metabolism us
Externí odkaz:
https://doaj.org/article/3aeea4fdb24949308434aa922bedcafd
Autor:
Anna J. Moyer, Fabian-Xosé Fernandez, Yicong Li, Donna K. Klinedinst, Liliana D. Florea, Yasuhiro Kazuki, Mitsuo Oshimura, Roger H. Reeves
Publikováno v:
Disease Models & Mechanisms, Vol 16, Iss 4 (2023)
Externí odkaz:
https://doaj.org/article/99e3b861410d482dab00aa682990760c
Autor:
Hiroyuki Satofuka, Satoshi Abe, Takashi Moriwaki, Akane Okada, Kanako Kazuki, Hiroshi Tanaka, Kyotaro Yamazaki, Genki Hichiwa, Kayoko Morimoto, Haruka Takayama, Yuji Nakayama, Shinya Hatano, Yutaro Yada, Yasufumi Murakami, Yoshihiro Baba, Mitsuo Oshimura, Kazuma Tomizuka, Yasuhiro Kazuki
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Trans-chromosomic (Tc) mice have helped the development of therapeutic antibodies, but chromosome instability limits its application. Here the authors develop a new line of Tc mice with full human Ig heavy and kappa loci integrated into the mouse art
Externí odkaz:
https://doaj.org/article/fb7ca36c22fa4c8995612d2e3884ca5e
Autor:
Narumi Uno, Shuta Takata, Shinya Komoto, Hitomaru Miyamoto, Yuji Nakayama, Mitsuhiko Osaki, Ryota Mayuzumi, Natsumi Miyazaki, Chiaki Hando, Satoshi Abe, Tetsushi Sakuma, Takashi Yamamoto, Teruhiko Suzuki, Yoshihiro Nakajima, Mitsuo Oshimura, Kazuma Tomizuka, Yasuhiro Kazuki
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Human artificial chromosomes (HACs) and mouse artificial chromosomes (MACs) are non-integrating chromosomal gene delivery vectors for molecular biology research. Recently, microcell-mediated chromosome transfer (MMCT) of HACs/MACs has been a
Externí odkaz:
https://doaj.org/article/00c4ef365e6945f0a014c8694d9f7564
Autor:
Keisuke Goto, Mitsuhiko Osaki, Runa Izutsu, Hiroshi Tanaka, Ryo Sasaki, Akimitsu Tanio, Hiroyuki Satofuka, Yasuhiro Kazuki, Manabu Yamamoto, Hiroyuki Kugoh, Hisao Ito, Mitsuo Oshimura, Yoshiyuki Fujiwara, Futoshi Okada
Publikováno v:
Diagnostic Pathology, Vol 17, Iss 1, Pp 1-12 (2022)
Abstract Instruction The human amphoterin-induced gene and open reading frame (AMIGO) was identified as a novel cell adhesion molecule of type I transmembrane protein. AMIGO2 is one of three members of the AMIGO family (AMIGO1, 2, and 3), and the sim
Externí odkaz:
https://doaj.org/article/9ad41b48f36f47758a608cc7a4b8266f
Autor:
Satoshi Abe, Kazuhisa Honma, Akane Okada, Kanako Kazuki, Hiroshi Tanaka, Takeshi Endo, Kayoko Morimoto, Takashi Moriwaki, Shusei Hamamichi, Yuji Nakayama, Teruhiko Suzuki, Shoko Takehara, Mitsuo Oshimura, Yasuhiro Kazuki
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Mammalian artificial chromosomes derived from native chromosomes have been applied to biomedical research and development by generating cell sources and transchromosomic (Tc) animals. Human artificial chromosome (HAC) is a precedent chromoso
Externí odkaz:
https://doaj.org/article/980a4802a45243dab043c205122e0872