Zobrazeno 1 - 10
of 111
pro vyhledávání: '"Mitsuo Nishikawa"'
Publikováno v:
Biotechnology Journal. 5:385-392
The Wnt canonical signaling pathway is essential for the early development of eukaryotic organisms and plays a key role in cell proliferation, differentiation, and oncogenesis. Moreover, the Wnt canonical signaling pathway contributes to the self-ren
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::597894b28d8abe7775d32c7ecb7a5eaf
https://doi.org/10.1002/biot.200900132
https://doi.org/10.1002/biot.200900132
Publikováno v:
Journal of Human Genetics. 53:447-453
Gene therapy using cDNA driven by an exogenous promoter is not suited for genetic disorders that require intrinsic expression of a transgene, such as hyperimmunoglobulin (Ig)M syndrome (HIGM), which is caused by mutations in the CD40L gene. The human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb74bbf33b653969ff822abb45775fd7
https://doi.org/10.1007/s10038-008-0268-0
https://doi.org/10.1007/s10038-008-0268-0
Autor:
Taku Tamura, Akiko Okumura, Ikuo Wada, Kenji Nagao, Kiyotaka Hatsuzawa, Akihiko Yoshimura, Mitsuo Nishikawa, Hisao Nagaya, Kazuko Saeki, Fumihiko Okumura
Publikováno v:
Journal of Biological Chemistry. 281:4495-4506
The cellular endomembrane system requires the proper kinetic balance of synthesis and degradation of its individual components, which is maintained in part by a specific membrane fusion apparatus. In this study, we describe the molecular properties o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97de0f8e5dddea52b9914e19a65cf830
https://doi.org/10.1074/jbc.m509715200
https://doi.org/10.1074/jbc.m509715200
Autor:
Candice G.T. Tahimic, Motonobu Katoh, Hiroshi Ueda, Toshiaki Inoue, Masahiro Kawahara, Xianying Ren, Mitsuo Nishikawa, Hidetoshi Yamada, Teruyuki Nagamune, Mitsuo Oshimura, Atsushi Kunisato
Publikováno v:
Journal of Human Genetics. 51:147-150
A number of gene delivery systems are currently being developed for potential use in gene therapy. Here, we demonstrate the feasibility of 21deltaqHAC, a newly developed human artificial chromosome (HAC), as a gene delivery system. We first introduce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c59fdf3655b4b2c84d8dc8cd6c9a170f
https://doi.org/10.1007/s10038-005-0334-9
https://doi.org/10.1007/s10038-005-0334-9
Autor:
Rosa Alba Rana, Francesco Paoletti, Maria Zingariello, Alessandro Pancrazzi, Lucia Bianchi, Eugenio Torre, Giovanni Migliaccio, Mitsuo Nishikawa, Elena Alfani, Alessandro M. Vannucchi, Anna Rita Migliaccio, Rodolfo Lorenzini, Angela Di Baldassarre
Publikováno v:
Blood. 105:3493-3501
Idiopathic myelofibrosis (IM) is a disease characterized by marrow fibrosis, abnormal stem/progenitor cell trafficking, and extramedullary hematopoiesis frequently associated with alterations in megakaryocytes (Mks). Mice harboring genetic alteration
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f65e655f3ccb36dd2a03fd3a6946fb36
https://doi.org/10.1182/blood-2004-04-1320
https://doi.org/10.1182/blood-2004-04-1320
Publikováno v:
Cellular Immunology. 234:77-80
Notch signaling is required for the early steps in T cell development. However, distribution of Notch ligands in the thymus anlages is not clear. We investigated the expressions of Delta like (Dll) 1 and Dll4 in the mouse thymus anlages. In the norma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7571740454b58192116a4059c9e800ad
https://doi.org/10.1016/j.cellimm.2005.06.009
https://doi.org/10.1016/j.cellimm.2005.06.009
Autor:
Mei Dong, Charles Giardina, Prashant R. Nambiar, Daniel W. Rosenberg, Alexander C. Lichtler, Kishore Guda, Mitsuo Nishikawa, Masako Nakanishi
Publikováno v:
Carcinogenesis. 25:2239-2246
Inbred mice differ dramatically in their sensitivity to the colon carcinogen, azoxymethane (AOM). Identifying genes associated with this differential susceptibility in mice may ultimately reveal molecular mechanisms responsible for colon carcinogenes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::624f5bccaf04b62c7a33f45fc04c2dde
https://doi.org/10.1093/carcin/bgh237
https://doi.org/10.1093/carcin/bgh237
Autor:
Shigeki Yokoyama, Shiro Imai, Kazuo Matsui, Susumu Ikehara, Mitsuo Nishikawa, Takafumi Kimura, Yoshiaki Sonoda, Jianfeng Wang
Publikováno v:
International Journal of Hematology. 79:328-333
Using the intra-bone marrow injection (IBMI) technique, we recently identified human cord blood-derived CD34- severe combined immunodeficiency (SCID)-repopulating cells (SRCs) with extensive lymphomyeloid reconstituting ability. In this study, we fur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87d613b857ed178e39066ed792ae1e80
https://doi.org/10.1532/ijh97.03158
https://doi.org/10.1532/ijh97.03158
Publikováno v:
Biochemical and Biophysical Research Communications. 308:927-932
A mouse homologue of Drosophila germ cell less, mouse germ cell less-1 (mgcl-1), encodes a nuclear envelope component essential for nuclear integrity. To analyze the molecular function of mGCL-1, we carried out two hybrid screening and found that mGC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfd0ed8c41894e80c74edfef2d9c4cf6
https://doi.org/10.1016/s0006-291x(03)01497-9
https://doi.org/10.1016/s0006-291x(03)01497-9
Publikováno v:
Development, Growth and Differentiation. 44:63-75
Multiple organs are induced in the primitive embryonic ectoderm excised from blastula stage Xenopus laevis embryos, under the strict control of mesoderm inducing factors. This in vitro system is useful for exploring the mechanisms of development. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::417ac3ca8e9cb3aef04fd59f41c8db1f
https://doi.org/10.1046/j.1440-169x.2002.00622.x
https://doi.org/10.1046/j.1440-169x.2002.00622.x