Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Mitsuo Mimura"'
Autor:
Mitsuo Mimura, Noriko Yamamoto, Kazuyuki Furuya, Mika Suzuki, Shizuo Yamada, Hiroaki Nejishima
Publikováno v:
Lower urinary tract symptoms. 5(1)
Objectives: The current study was undertaken to explore novel anti-androgens. We investigated a series of tetrahydroquinoline compounds and identified 1-(8-nitro-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-4-yl)ethane-1,2-diol (S-40542). Methods: A
Autor:
Kiyoshi Centr Res Inst Kaken Pharm Inoguchi, Tadashi Okuno, Satoru Ikegami, Gilda H. Loew, Jun Nakano, Akihiko Okuyama, Mitsuo Hayashida, Osafumi Shimada, Ping Huang, Nobuo Ishiyama, Hidenori Funamizu, Mitsuo Mimura
Publikováno v:
Journal of Medicinal Chemistry. 44:4082-4091
In the joint experimental and computational efforts reported here to obtain novel chemical entities as growth hormone secretagogues (GHSs), a small database of peptides and non-peptides known to have GHS activity was used to generate and assess a 3D
Publikováno v:
ChemInform. 23
A novel one-pot synthetic method was developed for the preparation of optically active cyanohydrin acetates. Racemic cyanohydrins were generated from aldehydes and acetone cyanohydrin by quinidine-catalyzed transhydrocyanation, and the resulting cyan
Autor:
Mitsuo Mimura, Mitsuo Hayashida, Yoshiyuki Hiyama, Yoshitaka Ohishi, M. Tamura, Y. Iida, S. Ikegami, K. Nomiyama
Publikováno v:
ChemInform. 25
Publikováno v:
ChemInform. 26
Various azaazulene derivatives were synthesized and their antiallergic activity was examined. The structure-activity relationship among various derivatives modified by introducing substituents at the 1-, 2-, or 3-position of the azaazulene ring was i
Publikováno v:
Bulletin of the Chemical Society of Japan. 65:111-120
A novel one-pot synthetic method was developed for the preparation of optically active cyanohydrin acetates. Racemic cyanohydrins were generated from aldehydes and acetone cyanohydrin by quinidine-catalyzed transhydrocyanation, and the resulting cyan
Publikováno v:
Chemicalpharmaceutical bulletin. 42(12)
Various azaazulene derivatives were synthesized and their antiallergic activity was examined. The structure-activity relationship among various derivatives modified by introducing substituents at the 1-,2-, or 3-position of the azaazulene ring was in
Autor:
Satoru Ikegami, Yoshitaka Ohishi, Yoshiyuki Hiyama, Mitsuo Mimura, Kiyoshi Nomiyama, Mitsuo Hayashida, Makoto Tamura, Yasuhito Iida
Publikováno v:
Chemicalpharmaceutical bulletin. 41(11)
Some (piperidinomethylene)bis(phosphonic acid) derivatives were prepared and their activity to inhibit a rise in serum calcium induced by parathyroid hormone in thyroparathyroidectomised rats was evaluated. Several (4-alkylidene-, 4,4-dialkyl-, or 4-
Autor:
Yasuo Yoneda, Mitsuo Hayashida, Shinji Tauchi, Akinori Aoyama, Tadashi Okuno, Nobuo Ishiyama, Kiyoshi Inoguchi, Mitsuo Mimura, Kiyoharu Ukai, Hirohide Ishige, Takeshi Kiyofuji
Publikováno v:
HETEROCYCLES. 67:561
The discovery and the SAR of acylproline derivatives as highly potent growth hormone secretagogues (GHSs) with good oral bioavailability are described. One representative compound, N-[3-(2,2-dimethylpropylamino)-2-hydroxypropyl]-2(R)-[l-(2,2-dimethyl
Autor:
Masahiro Fujii, Mitsuo Hayashida, Kazuhiko Kimura, Teruo Nakanishi, Mitsuo Mimura, Jun Nakano
Publikováno v:
Chemical and Pharmaceutical Bulletin. 36:1399-1403
The optical isomers of 2-acetyl-7-(2-hydroxy-3-isopropylaminopropoxy)benzofuran hydrochloride (1a, b) (befunolol·HCl) were synthesized by using (S)-1, 2-O-isopropylideneglycerol (4) as a common chiral building block, and their β-adrenergic blocking