Zobrazeno 1 - 10
of 213
pro vyhledávání: '"Mitsuo Itakura"'
Autor:
Katsuhiko Yoshimoto, Noriko Mizusawa, Mitsuo Itakura, Takeo Iwata, Nagakatsu Harada, Izumi Ohigashi
Publikováno v:
Islets
article-version (VoR) Version of Record
article-version (VoR) Version of Record
The aim of this study was to identify genes that are specifically expressed in pancreatic islet β-cells (hereafter referred to as β-cells). Large-scale complementary DNA-sequencing analysis was performed for 3,429 expressed sequence tags derived fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8b1cc5b483b21fb17294cca835b695b
https://doi.org/10.1080/19382014.2021.1982325
https://doi.org/10.1080/19382014.2021.1982325
Autor:
Hiroshi Inoue, Nobuyuki Kamata, Chikara Hirono, Shinichi Fujimoto, Kei Tobiume, Mitsuo Itakura, Kuniko Mizuta, Makoto Sugita, Kazumi Kubozono, Ta To Tran
Publikováno v:
Journal of Cellular Physiology. 229:181-190
TMEM16E/GDD1 has been shown to be responsible for the bone-related late-onset disease gnathodiaphyseal dysplasia (GDD), with the dominant allele (TMEM16E(gdd) ) encoding a missense mutation at Cys356. Additionally, several recessive loss-of-function
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab35b61a253e97920f9580a169a66a1d
https://doi.org/10.1002/jcp.24431
https://doi.org/10.1002/jcp.24431
Autor:
Susumu Kitayama, Hiroshi Inoue, Mitsuo Itakura, Takao Suzuki, Shigeru Takeshita, Maki Moritani
Publikováno v:
Genes & Genetic Systems. 87:341-346
We have previously identified four significant quantitative trait loci (QTL) affecting plasma glucose concentrations on F(2) progeny of hypoinsulinemic diabetic Akita mice, heterozygous for the Ins2 gene Cys96Tyr mutation, and non-diabetic A/J mice,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c449092139e13b1aae7a5d670c021369
https://doi.org/10.1266/ggs.87.341
https://doi.org/10.1266/ggs.87.341
Autor:
Hiroshi Inoue, Maki Moritani, Takao Suzuki, Mitsuo Itakura, Shigeru Takeshita, Susumu Kitayama
Publikováno v:
Genes & Genetic Systems. 87:253-264
We have previously identified significant quantitative trait loci (QTL) Dbm1 (diabetic modifier QTL 1) on chromosome 6, affecting plasma glucose and insulin concentrations and body weight on F(2) progeny of hypoinsulinemic diabetic Akita mice, with t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f70775bd09c52839bca8838b1489df1a
https://doi.org/10.1266/ggs.87.253
https://doi.org/10.1266/ggs.87.253
Autor:
Tsutomu Ogata, Tokuo Mukai, Yoshiya Ito, Kenji Fujieda, Mitsuo Itakura, Hiroshi Inoue, Yukiko Sakamoto, Chizuko Kimura, Natsumi Kangawa
Publikováno v:
Clinical Endocrinology. 76:78-87
Summary Context To date, approximately 35 different POU1F1 mutations have been described in patients with familial and sporadic combined pituitary hormone deficiency (CPHD) from different ethnic backgrounds. The majority are missense mutations cluste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d156580f865e3724972f491dc2b57401
https://doi.org/10.1111/j.1365-2265.2011.04165.x
https://doi.org/10.1111/j.1365-2265.2011.04165.x
Autor:
Hiroshi Inoue, Toshiaki Sano, Natsumi Kangawa, Yukiko Sakamoto, Tsutomu Ogata, Chizuko Kimura, Zhi Rong Qian, Kenji Fujieda, Mitsuo Itakura
Publikováno v:
Molecular and Cellular Endocrinology. 345:1-15
In the current study, to elucidate the molecular basis of cell type-specific expression of the GH-secretagogue/ghrelin receptor type 1A (GHSR1A), we characterized the structure and putative promoter region of the rat Ghsr gene. We identified an alter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81feb3d4471fe321d11c968fecc47eab
https://doi.org/10.1016/j.mce.2011.06.034
https://doi.org/10.1016/j.mce.2011.06.034
Autor:
Tsutomu Ogata, Yukiko Sakamoto, Kenji Fujieda, Atsuko Kinouchi, Chizuko Kimura, Mitsuo Itakura, Yosuke Shigematsu, Reiko Horikawa, Natsumi Kangawa, Hiroshi Inoue
Publikováno v:
Clinical Endocrinology. 74:223-233
Summary Context Growth hormone–releasing hormone receptor (GHRHR) gene mutations have been identified in patients of different ethnic origins with isolated GH deficiency (IGHD) type IB. However, the prevalence of these mutations in the Japanese pop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f3a378ea91fb93cf7a38d468793e31c8
https://doi.org/10.1111/j.1365-2265.2010.03911.x
https://doi.org/10.1111/j.1365-2265.2010.03911.x
Autor:
Tsutomu Ogata, Koji Muroya, Keinosuke Fujita, Mitsuo Itakura, Maki Fukami, Takahiro Mochizuki, Manami Iso
Publikováno v:
Endocrine Journal. 57:171-174
We report on a Japanese girl with HDR (hypoparathyroidism, sensorineural deafness, and renal dysplasia) syndrome who developed diabetes mellitus (DM) at three years of age (blood glucose 713 mg/dL, HbA(1c) 8.0%) in the absence of anti-glutamic acid d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::959abd4f58b39848ebc15c9da317a1d1
https://doi.org/10.1507/endocrj.k09e-313
https://doi.org/10.1507/endocrj.k09e-313
Autor:
Mitsuo Itakura, Masatoshi Takeda, Kazutaka Ohi, Ryota Hashimoto, Toshihito Tanahashi, Shu-ichi Ueno, Masahito Nakataki, Shusuke Numata, Jun-ichi Iga, Tetsuro Ohmori, Yoshihiro Nakadoi
Publikováno v:
NeuroMolecular Medicine. 12:243-247
Disrupted-in-schizophrenia 1 (DISC1), a known genetic risk factor for schizophrenia (SZ) and major depressive disorder (MDD), interacts with several proteins and some of them are reported to be genetically associated with SZ. Pericentrin (PCNT) also
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ad6b123f6c98de24802c62ffe563167
https://doi.org/10.1007/s12017-009-8106-x
https://doi.org/10.1007/s12017-009-8106-x
Autor:
Akiko Sukeno, Masamichi Kuwajima, Takeo Iwata, Martin Wabitsch, Noriko Mizusawa, Yoshio Hayashi, Mitsuo Itakura, Naozumi Ishimaru, Katsuhiko Yoshimoto
Publikováno v:
Biochemical and Biophysical Research Communications. 388:511-516
Obesity is considered a chronic low-grade inflammatory status and the stromal vascular fraction (SVF) cells of adipose tissue (AT) are considered a source of inflammation-related molecules. We identified YKL-40 as a major protein secreted from SVF ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2920ce22b932247d6ce57344d8e80081
https://doi.org/10.1016/j.bbrc.2009.08.024
https://doi.org/10.1016/j.bbrc.2009.08.024